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Management of HAM/TSP: Systematic Review and Consensus-based Recommendations 2019

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dc.contributor.author Araujo, Abelardo
dc.contributor.author Bangham, Charles R. M.
dc.contributor.author Casseb, Jorge
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Jacobson, Steve
dc.contributor.author Martin, Fabiola
dc.contributor.author Penalva-de-Oliveira, Augusto
dc.contributor.author Puccioni-Sohler, Marzia
dc.contributor.author Taylor, Graham P.
dc.contributor.author Yamano, Yoshihisa
dc.date.accessioned 2021-06-08T15:46:14Z
dc.date.available 2021-06-08T15:46:14Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9497
dc.description.abstract PURPOSE OF REVIEW: To provide an evidence-based approach to the use of therapies that are prescribed to improve the natural history of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)-a rare disease. RECENT FINDINGS: All 41 articles on the clinical outcome of disease-modifying therapy for HAM/TSP were included in a systematic review by members of the International Retrovirology Association; we report here the consensus assessment and recommendations. The quality of available evidence is low, based for the most part on observational studies, with only 1 double-masked placebo-controlled randomized trial. SUMMARY: There is evidence to support the use of both high-dose pulsed methyl prednisolone for induction and low-dose (5 mg) oral prednisolone as maintenance therapy for progressive disease. There is no evidence to support the use of antiretroviral therapy. There is insufficient evidence to support the use of interferon-α as a first-line therapy en_US
dc.language.iso eng
dc.publisher Wolters Kluwer Health
dc.relation.ispartofseries Neurology. Clinical Practice
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Spinal Cord en_US
dc.subject Viral infections en_US
dc.title Management of HAM/TSP: Systematic Review and Consensus-based Recommendations 2019 en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1212/CPJ.0000000000000832
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.25
dc.relation.issn 2163-0933


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