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Preoperative breast magnetic resonance imaging in patients with ductal carcinoma in situ: a systematic review for the European Commission Initiative on Breast Cancer (ECIBC)

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dc.contributor.author Canelo-Aybar, Carlos
dc.contributor.author Taype-Rondán, Álvaro
dc.contributor.author Zafra-Tanaka, Jessica Hanae
dc.contributor.author Rigau, David
dc.contributor.author Graewingholt, Axel
dc.contributor.author Lebeau, Annette
dc.contributor.author Pérez-Gómez, Elsa
dc.contributor.author Rossi, Paolo Giorgi
dc.contributor.author Langedam, Miranda
dc.contributor.author Posso, Margarita
dc.contributor.author Parmelli, Elena
dc.contributor.author Saz-Parkinson, Zuleika
dc.contributor.author Alonso-Coello, Pablo
dc.date.accessioned 2021-06-08T15:46:14Z
dc.date.available 2021-06-08T15:46:14Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9503
dc.description.abstract OBJECTIVE: To evaluate the impact of preoperative MRI in the management of Ductal carcinoma in situ (DCIS). METHODS: We searched the PubMed, EMBASE and Cochrane Library databases to identify randomised clinical trials (RCTs) or cohort studies assessing the impact of preoperative breast MRI in surgical outcomes, treatment change or loco-regional recurrence. We provided pooled estimates for odds ratios (OR), relative risks (RR) and proportions and assessed the certainty of the evidence using the GRADE approach. RESULTS: We included 3 RCTs and 23 observational cohorts, corresponding to 20,415 patients. For initial breast-conserving surgery (BCS), the RCTs showed that MRI may result in little to no difference (RR 0.95, 95% CI 0.90 to 1.00) (low certainty); observational studies showed that MRI may have no difference in the odds of re-operation after BCS (OR 0.96; 95% CI 0.36 to 2.61) (low certainty); and uncertain evidence from RCTs suggests little to no difference with respect to total mastectomy rate (RR 0.91; 95% CI 0.65 to 1.27) (very low certainty). We also found that MRI may change the initial treatment plans in 17% (95% CI 12 to 24%) of cases, but with little to no effect on locoregional recurrence (aHR = 1.18; 95% CI 0.79 to 1.76) (very low certainty). CONCLUSION: We found evidence of low to very low certainty which may suggest there is no improvement of surgical outcomes with pre-operative MRI assessment of women with DCIS lesions. There is a need for large rigorously conducted RCTs to evaluate the role of preoperative MRI in this population. KEY POINTS: • Evidence of low to very low certainty may suggest there is no improvement in surgical outcomes with pre-operative MRI. • There is a need for large rigorously conducted RCTs evaluating the role of preoperative MRI to improve treatment planning for DCIS en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries European Radiology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Magnetic resonance imaging en_US
dc.subject Breast cancer en_US
dc.subject Ductal carcinoma in situ en_US
dc.title Preoperative breast magnetic resonance imaging in patients with ductal carcinoma in situ: a systematic review for the European Commission Initiative on Breast Cancer (ECIBC) en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1007/s00330-021-07873-2
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.12
dc.relation.issn 1432-1084


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