Universidad Peruana Cayetano Heredia

Self-report screening instruments differentiate bipolar disorder and borderline personality disorder

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dc.contributor.author Palmer, Brian A.
dc.contributor.author Pahwa, Mehak
dc.contributor.author Geske, Jennifer R.
dc.contributor.author Kung, Simon
dc.contributor.author Nassan, Malik
dc.contributor.author Schak, Kathryn M.
dc.contributor.author Alarcón, Renato D.
dc.contributor.author Frye, Mark A.
dc.contributor.author Singh, Balwinder
dc.date.accessioned 2021-06-08T15:46:15Z
dc.date.available 2021-06-08T15:46:15Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9510
dc.description.abstract BACKGROUND: Bipolar disorder (BD) and borderline personality disorder (BPD) share overlapping phenomenology and are frequently misdiagnosed. This study investigated the diagnostic accuracy of the Mood Disorder Questionnaire (MDQ) and McLean Screening Instrument for Borderline Personality Disorder (MSI) in a clinical inpatient setting and whether individual screening items could differentiate BD from BPD. METHODS: 757 sequential inpatients admitted to a Mood Disorder Unit completed both the MDQ and MSI. Screen positive for the MDQ was defined as ≥7/13 symptoms endorsed with concurrence and at least moderate impact. Screen positive for the MSI was defined as a score of ≥7. The clinical discharge summary diagnosis completed by a board-certified psychiatrist was used as the reference standard to identify concordance rates of a positive screen with clinical diagnosis. Individual items predicting one disorder and simultaneously predicting absence of other disorder by odds ratio (OR>and <1) were identified. RESULTS: Both screening instruments were more specific than sensitive (MDQ 83.7%/ 67.8%, MSI 73.2% / 63.3%). MDQ individual items (elevated mood, grandiosity, increased energy, pressured speech, decreased need for sleep, hyperactivity) were significant predictors of BD diagnosis and non-predictors of BPD diagnosis. Whereas MSI subitem, self-harm behaviors/suicidal attempts predicted BPD in the absence of BD; distrust and irritability were additional predictors of BPD. CONCLUSION: While this study is limited by the lack of structured diagnostic interview, these data provide differential symptoms to discriminate BD and BPD. Further work with larger datasets and more rigorous bioinformatics machine learning methodology is encouraged to continue to identify distinguishing features of these two disorders to guide diagnostic precision and subsequent treatment recommendations en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Brain and Behavior
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject bipolar disorder en_US
dc.subject borderline personality disorder en_US
dc.subject MDQ en_US
dc.subject MSI en_US
dc.title Self-report screening instruments differentiate bipolar disorder and borderline personality disorder en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/brb3.2201
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.04
dc.relation.issn 2162-3279


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