Survival in patients with carcinomas presenting with bone metastasis at diagnosis: a SEER population-based cohort study

Fuentes Rivera Lau, Lorena

dc.contributor.advisor	Pretell Mazzini, Juan Abelardo Augusto	es_ES
dc.contributor.author	Fuentes Rivera Lau, Lorena	es_ES
dc.date.accessioned	2021-06-14T20:28:49Z
dc.date.issued	2021
dc.identifier.other	205242	es_ES
dc.identifier.uri	https://hdl.handle.net/20.500.12866/9541
dc.description.abstract	Introduction: Carcinoma metastasis to bone is a common reason for consultation to orthopedic surgeons. The presence of bone metastases (BM) is usually associated with poor prognosis which is worsened in the presence of synchronous metastases. The purpose of this study was to: (1) identify the most common carcinomas presenting with BM at diagnosis, to (2) analyze their survival, and (3) compare this against the survival of patients with additional synchronous metastasis based on a large population analysis. Materials and methods: Patients diagnosed with carcinoma between January 2010 and December 2015 were identified from the Surveillance, Epidemiology and End Results (SEER) database. The most common carcinomas presenting with BM at diagnosis were identified. Survival based on the presence of BM and synchronous metastases (lung, brain, liver, lymph nodes) was evaluated with Kaplan-Meier analysis. Five-year survival (%) stratified by carcinoma type was calculated. Hazard ratio (HR) for mortality comparing isolated BM to other synchronous metastases was performed. Results: A total of 4.85% of patients (98,606/2,035,204) with carcinoma presented with BM at diagnosis, most commonly from a lung primary. Five-year survival with isolated BM was lowest in patients with pancreatic carcinoma (5.8%, 95% CI 3.0-9.9%), and highest in patients with breast carcinoma (41.1%, 95% CI 38.6-43.5%). Synchronous metastases increased significantly the risk of mortality within the majority of carcinomas. Conclusion: BM at diagnosis has a poor prognosis which is worsened if synchronous metastases are present; a fact to consider when planning orthopedic interventions. Level of evidence: Level III, prognostic study.	es_ES
dc.format	application/pdf	es_ES
dc.language.iso	eng	es_ES
dc.publisher	Universidad Peruana Cayetano Heredia	es_ES
dc.rights	info:eu-repo/semantics/restrictedAccess	es_ES
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es	es_ES
dc.subject	Survival	es_ES
dc.subject	Bone Metastasis	es_ES
dc.subject	Carcinoma	es_ES
dc.subject	Breast	es_ES
dc.subject	Pancreas	es_ES
dc.subject	Prostate	es_ES
dc.subject	Lung	es_ES
dc.subject	Renal	es_ES
dc.title	Survival in patients with carcinomas presenting with bone metastasis at diagnosis: a SEER population-based cohort study	es_ES
dc.type	info:eu-repo/semantics/bachelorThesis	es_ES
thesis.degree.name	Médico Cirujano	es_ES
thesis.degree.grantor	Universidad Peruana Cayetano Heredia. Facultad de Medicina Alberto Hurtado	es_ES
thesis.degree.discipline	Medicina	es_ES
dc.publisher.country	PE	es_ES
dc.subject.ocde	http://purl.org/pe-repo/ocde/ford#3.01.09	es_ES
dc.subject.ocde	http://purl.org/pe-repo/ocde/ford#3.02.21	es_ES
dc.subject.ocde	http://purl.org/pe-repo/ocde/ford#3.03.09	es_ES
renati.author.dni	74119051
renati.advisor.orcid	https://orcid.org/0000-0002-4893-0341	es_ES
renati.advisor.dni	07637562
renati.type	http://purl.org/pe-repo/renati/type#trabajoDeInvestigacion	es_ES
renati.level	http://purl.org/pe-repo/renati/nivel#tituloProfesional	es_ES
renati.discipline	912016	es_ES
renati.juror	Vera Rosas, Francisco René	es_ES
renati.juror	Venegas Ojeda, Diego Rolando	es_ES
renati.juror	Tejada Benavides, Hermes Wignard	es_ES