Universidad Peruana Cayetano Heredia

Microsatellite analysis reveals connectivity among geographically distant transmission zones of Plasmodium vivax in the Peruvian Amazon: A critical barrier to regional malaria elimination

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dc.contributor.author Manrique Valverde, Paulo Cesar
dc.contributor.author Miranda-Alban, Julio
dc.contributor.author Alarcon-Baldeon, Jhonatan
dc.contributor.author Ramirez, Roberson
dc.contributor.author Carrasco Escobar, Gabriel
dc.contributor.author Herrera, Henry
dc.contributor.author Guzman Guzman, Mitchel Anthony
dc.contributor.author Rosas-Aguirre, Angel
dc.contributor.author Llanos Cuentas, Elmer Alejandro
dc.contributor.author Vinetz, Joseph Michael
dc.contributor.author Escalante, Ananias A.
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.date.accessioned 2021-07-12T20:18:17Z
dc.date.available 2021-07-12T20:18:17Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/9606
dc.description.abstract Despite efforts made over decades by the Peruvian government to eliminate malaria, Plasmodium vivax remains a challenge for public health decision-makers in the country. The uneven distribution of its incidence, plus its complex pattern of dispersion, has made ineffective control measures based on global information that lack the necessary detail to understand transmission fully. In this sense, population genetic tools can complement current surveillance. This study describes the genetic diversity and population structure from September 2012 to March 2015 in three geographically distant settlements, Cahuide (CAH), Lupuna (LUP) and Santa Emilia (STE), located in the Peruvian Amazon. A total 777 P. vivax mono-infections, out of 3264, were genotyped. Among study areas, LUP showed 19.7% of polyclonal infections, and its genetic diversity (Hexp) was 0.544. Temporal analysis showed a significant increment of polyclonal infections and Hexp, and the introduction and persistence of a new parasite population since March 2013. In STE, 40.1% of infections were polyclonal, with Hexp = 0.596. The presence of four genetic clusters without signals of clonal expansion and infections with lower parasite densities compared against the other two areas were also found. At least four parasite populations were present in CAH in 2012, where, after June 2014, malaria cases decreased from 213 to 61, concomitant with a decrease in polyclonal infections (from 0.286 to 0.18), and expectedly variable Hexp. Strong signals of gene flow were present in the study areas and wide geographic distribution of highly diverse parasite populations were found. This study suggests that movement of malaria parasites by human reservoirs connects geographically distant malaria transmission areas in the Peruvian Amazon. The maintenance of high levels of parasite genetic diversity through human mobility is a critical barrier to malaria elimination in this region. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Adolescent en_US
dc.subject Adult en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Young Adult en_US
dc.subject Child Preschool en_US
dc.subject Infant en_US
dc.subject Peru epidemiology en_US
dc.subject Aged en_US
dc.subject Middle Aged en_US
dc.subject Child en_US
dc.subject Longitudinal Studies en_US
dc.subject Aged 80 and over en_US
dc.subject Infant Newborn en_US
dc.subject Genotype en_US
dc.subject Genotyping Techniques en_US
dc.subject Plasmodium vivax classification genetics isolation & purification en_US
dc.subject Incidence en_US
dc.subject Disease Transmission Infectious en_US
dc.subject Molecular Epidemiology en_US
dc.subject Malaria Vivax epidemiology parasitology transmission en_US
dc.subject Microsatellite Repeats en_US
dc.title Microsatellite analysis reveals connectivity among geographically distant transmission zones of Plasmodium vivax in the Peruvian Amazon: A critical barrier to regional malaria elimination en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0007876
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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