dc.contributor.author |
Ugarte Gil, Manuel Francisco |
|
dc.contributor.author |
Pons-Estel, Guillermo J. |
|
dc.contributor.author |
Griffin, Russell |
|
dc.contributor.author |
Vilá, Luis M. |
|
dc.contributor.author |
Reveille, John D. |
|
dc.contributor.author |
Alarcón, Graciela S. |
|
dc.date.accessioned |
2021-10-04T23:00:55Z |
|
dc.date.available |
2021-10-04T23:00:55Z |
|
dc.date.issued |
2021 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/9773 |
|
dc.description.abstract |
OBJECTIVE: To determine the difference in outcomes in patients who achieved or did not achieve the 2019 European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) criteria. METHODS: Patients from the LUpus in MInorities, NAture versus nurture (LUMINA) cohort were included. For these analyses, we compared those patients who achieved the 2019 EULAR/ACR criteria any time during follow-up to those who did not. The predefined outcomes were the last Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI) scores and survival. Univariable and multivariable negative binomial regression models were performed; adjustment models were based on a forward selection process. RESULTS: In total, 98 of 640 patients never achieved the 2019 EULAR/ACR criteria. There was no difference in mean baseline SDI score among the patients who did not achieve the criteria compared to those who did. Conversely, the mean ± SD SDI score at last visit was lower for those who never achieved the criteria (1.2 ± 1.7 versus 2.0 ± 2.3, P = 0.0004). In the final adjusted model, the SDI score at last visit was 31% lower for those who never achieved the criteria (P = 0.0077). These patients were also more likely to survive, but this was not statistically significant. CONCLUSION: In our cohort, patients who did not achieve the 2019 EULAR/ACR criteria accrued less damage, suggesting that these criteria could allow us to identify a subset of patients with more severe disease than allowed by previous criteria. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Wiley |
|
dc.relation.ispartofseries |
Arthritis Care and Research |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
Humans |
en_US |
dc.subject |
Prognosis |
en_US |
dc.subject |
Rheumatology |
en_US |
dc.subject |
Severity of Illness Index |
en_US |
dc.subject |
Lupus Erythematosus |
en_US |
dc.subject |
Systemic/diagnosis/ethnology/therapy |
en_US |
dc.subject |
Predictive Value of Tests |
en_US |
dc.subject |
Time Factors |
en_US |
dc.subject |
United States/epidemiology |
en_US |
dc.title |
Achievement of the 2019 European Alliance of Associations for Rheumatology/American College of Rheumatology Criteria for Systemic Lupus Erythematosus and Amount of Damage Accrual: Results From a Multiethnic Multicenter Cohort |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1002/acr.24213 |
|
dc.relation.issn |
2151-4658 |
|