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Achievement of the 2019 European Alliance of Associations for Rheumatology/American College of Rheumatology Criteria for Systemic Lupus Erythematosus and Amount of Damage Accrual: Results From a Multiethnic Multicenter Cohort

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dc.contributor.author Ugarte Gil, Manuel Francisco
dc.contributor.author Pons-Estel, Guillermo J.
dc.contributor.author Griffin, Russell
dc.contributor.author Vilá, Luis M.
dc.contributor.author Reveille, John D.
dc.contributor.author Alarcón, Graciela S.
dc.date.accessioned 2021-10-04T23:00:55Z
dc.date.available 2021-10-04T23:00:55Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9773
dc.description.abstract OBJECTIVE: To determine the difference in outcomes in patients who achieved or did not achieve the 2019 European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) criteria. METHODS: Patients from the LUpus in MInorities, NAture versus nurture (LUMINA) cohort were included. For these analyses, we compared those patients who achieved the 2019 EULAR/ACR criteria any time during follow-up to those who did not. The predefined outcomes were the last Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI) scores and survival. Univariable and multivariable negative binomial regression models were performed; adjustment models were based on a forward selection process. RESULTS: In total, 98 of 640 patients never achieved the 2019 EULAR/ACR criteria. There was no difference in mean baseline SDI score among the patients who did not achieve the criteria compared to those who did. Conversely, the mean ± SD SDI score at last visit was lower for those who never achieved the criteria (1.2 ± 1.7 versus 2.0 ± 2.3, P = 0.0004). In the final adjusted model, the SDI score at last visit was 31% lower for those who never achieved the criteria (P = 0.0077). These patients were also more likely to survive, but this was not statistically significant. CONCLUSION: In our cohort, patients who did not achieve the 2019 EULAR/ACR criteria accrued less damage, suggesting that these criteria could allow us to identify a subset of patients with more severe disease than allowed by previous criteria. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Arthritis Care and Research
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Prognosis en_US
dc.subject Rheumatology en_US
dc.subject Severity of Illness Index en_US
dc.subject Lupus Erythematosus en_US
dc.subject Systemic/diagnosis/ethnology/therapy en_US
dc.subject Predictive Value of Tests en_US
dc.subject Time Factors en_US
dc.subject United States/epidemiology en_US
dc.title Achievement of the 2019 European Alliance of Associations for Rheumatology/American College of Rheumatology Criteria for Systemic Lupus Erythematosus and Amount of Damage Accrual: Results From a Multiethnic Multicenter Cohort en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/acr.24213
dc.relation.issn 2151-4658


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