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Adjuvants: friends in vaccine formulations against infectious diseases

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dc.contributor.author Guerrero Manriquez, G. G.
dc.contributor.author Tuero Ochoa, Iskra
dc.date.accessioned 2021-10-04T23:00:55Z
dc.date.available 2021-10-04T23:00:55Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9777
dc.description.abstract Infectious diseases represent a major cause of deaths worldwide. No vaccine or effective treatment exists nowadays, especially against intracellular pathogens. The increase in multiple drug and superbug antibiotic resistance strains, excessive medication, or misuse of drugs has prompted the search for other safe and effective alternatives. Consistent with this, adjuvants (Latin word "adjuvare": "help or aid") co-administered (Exo) in vaccines have emerged as a promising alternative to initiate and boost an innate, downstream signal that led to adaptative immune response. Nowadays, a promising model of strong immunogens and adjuvants at mucosal sites are the microbial bacterial toxins. Other adjuvants that are also used and might successfully replace aluminum salts in combination with nanotechnology are CpG-ODN, poly IC, type I IFNs, mRNA platforms. Therefore, in the present review, we focused to revisit the old to the new adjuvants compounds, the properties that make them friends in vaccine formulations against infectious diseases en_US
dc.language.iso eng
dc.publisher Taylor and Francis
dc.relation.ispartofseries Human Vaccines and Immunotherapeutics
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Bacterial toxins en_US
dc.subject CpGODN en_US
dc.subject immunostimulants en_US
dc.subject MPL en_US
dc.subject Poly IC en_US
dc.subject Type I IFNs en_US
dc.title Adjuvants: friends in vaccine formulations against infectious diseases en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1080/21645515.2021.1934354
dc.relation.issn 2164-554X


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