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Antimicrobial Resistance of Helicobacter pylori in Gastric Biopsy Samples from Lima/Peru

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dc.contributor.author Bilgilier, C.
dc.contributor.author Thannesberger, J.
dc.contributor.author Ojeda Cisneros, M.
dc.contributor.author Boehnke, K.
dc.contributor.author Wu, J.
dc.contributor.author Xi, C.
dc.contributor.author Bussalleu Rivera, Alejandro Joaquin
dc.contributor.author Steininger, C.
dc.date.accessioned 2021-10-04T23:00:55Z
dc.date.available 2021-10-04T23:00:55Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9784
dc.description.abstract Background: Helicobacter pylori prevalence and gastric cancer rates are remarkably high in Peru. Effective antimicrobial regimens are essential for successful H. pylori eradication. We aimed at assessing antimicrobial resistance rates to first- and second-line therapeutic agents in H. pylori strains detected in gastric biopsy samples. Materials and Methods: Gastric biopsy samples (antrum and corpus) were collected from therapy-naive patients (n = 154). H. pylori presence in the samples was confirmed by histopathology. Genotypic resistance to clarithromycin and quinolones was determined by real-time PCR. Results: Histology results were 100% concordant with PCR results (97/154; 63% H. pylori-positive in both). In 6% (6/97) of the patients, we found discordant results of H. pylori infection in antrum and corpus samples from the same patient. Resistance rates to clarithromycin and quinolone were 34% (33/97) and 68% (56/82), respectively. Antimicrobial resistance to both antimicrobials was 30% (25/82). Conclusion: Antimicrobial resistance rates of H. pylori to clarithromycin and quinolones are very high in Lima, Peru. Many first- and second-line, empiric eradication regimens may not be recommended for Peruvian patients en_US
dc.language.iso eng
dc.publisher Mary Ann Liebert
dc.relation.ispartofseries Microbial Drug Resistance
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject clarithromycin en_US
dc.subject fluoroquinolones en_US
dc.subject gyrA en_US
dc.subject Helicobacter pylori en_US
dc.subject Lima en_US
dc.subject Peru en_US
dc.subject resistance en_US
dc.title Antimicrobial Resistance of Helicobacter pylori in Gastric Biopsy Samples from Lima/Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1089/mdr.2020.0241
dc.relation.issn 1931-8448


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