Universidad Peruana Cayetano Heredia

Genome-wide analyses of human noroviruses provide insights on evolutionary dynamics and evidence of coexisting viral populations evolving under recombination constraints

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dc.contributor.author Tohma, Kentaro
dc.contributor.author Lepore, Cara J.
dc.contributor.author Martinez, Magaly
dc.contributor.author Degiuseppe, Juan I.
dc.contributor.author Khamrin, Pattara
dc.contributor.author Saito, Mayuko
dc.contributor.author Mayta, Holger
dc.contributor.author Nwaba, Amy U. Amanda
dc.contributor.author Ford-Siltz, Lauren A.
dc.contributor.author Green, Kim Y.
dc.contributor.author Galeano, Maria E.
dc.contributor.author Zimic-Peralta, Mirko Juan
dc.contributor.author Stupka, Juan A.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Maneekarn, Niwat
dc.contributor.author Ushijima, Hiroshi
dc.contributor.author Parra, Gabriel I.
dc.date.accessioned 2021-10-04T23:00:58Z
dc.date.available 2021-10-04T23:00:58Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9829
dc.description.abstract Norovirus is a major cause of acute gastroenteritis worldwide. Over 30 different genotypes, mostly from genogroup I (GI) and II (GII), have been shown to infect humans. Despite three decades of genome sequencing, our understanding of the role of genomic diversification across continents and time is incomplete. To close the spatiotemporal gap of genomic information of human noroviruses, we conducted a large-scale genome-wide analyses that included the nearly full-length sequencing of 281 archival viruses circulating since the 1970s in over 10 countries from four continents, with a major emphasis on norovirus genotypes that are currently underrepresented in public genome databases. We provided new genome information for 24 distinct genotypes, including the oldest genome information from 12 norovirus genotypes. Analyses of this new genomic information, together with those publicly available, showed that (i) noroviruses evolve at similar rates across genomic regions and genotypes; (ii) emerging viruses evolved from transiently-circulating intermediate viruses; (iii) diversifying selection on the VP1 protein was recorded in genotypes with multiple variants; (iv) non-structural proteins showed a similar branching on their phylogenetic trees; and (v) contrary to the current understanding, there are restrictions on the ability to recombine different genomic regions, which results in co-circulating populations of viruses evolving independently in human communities. This study provides a comprehensive genetic analysis of diverse norovirus genotypes and the role of non-structural proteins on viral diversification, shedding new light on the mechanisms of norovirus evolution and transmission en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Pathogens
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Genomics en_US
dc.subject Norovirus en_US
dc.subject Polymerases en_US
dc.subject Viral evolution en_US
dc.subject Phylogenetic analysis en_US
dc.subject Capsids en_US
dc.subject Microbial mutation en_US
dc.subject Genome analysis en_US
dc.title Genome-wide analyses of human noroviruses provide insights on evolutionary dynamics and evidence of coexisting viral populations evolving under recombination constraints en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.ppat.1009744
dc.relation.issn 1553-7374


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