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Geographically targeted interventions versus mass drug administration to control Taenia solium cysticercosis, Peru

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dc.contributor.author O'Neal, Seth E.
dc.contributor.author Pray, I.W.
dc.contributor.author Vilchez Barreto, Percy Mcquen
dc.contributor.author Gamboa Morán, Ricardo
dc.contributor.author Muro Ecca, Claudio Alberto
dc.contributor.author Moyano, L.M.
dc.contributor.author Ayvar, V.
dc.contributor.author Gavidia, C.M.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Gonzalez Zariquiey, Armando Emiliano
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author Cysticercosis Working Group in Peru
dc.date.accessioned 2021-10-04T23:00:58Z
dc.date.available 2021-10-04T23:00:58Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9830
dc.description.abstract Optimal control strategies for Taenia solium taeniasis and cysticercosis have not been determined. We conducted a 2-year cluster randomized trial in Peru by assigning 23 villages to 1 of 3 geographically targeted intervention approaches. For ring screening (RS), participants living near pigs with cysticercosis were screened for taeniasis; identified cases were treated with niclosamide. In ring treatment (RT), participants living near pigs with cysticercosis received presumptive treatment with niclosamide. In mass treatment (MT), participants received niclosamide treatment every 6 months regardless of location. In each approach, half the villages received targeted or mass oxfendazole for pigs (6 total study arms). We noted significant reductions in seroincidence among pigs in all approaches (67.1% decrease in RS, 69.3% in RT, 64.7% in MT; p<0.001), despite a smaller proportion of population treated by targeted approaches (RS 1.4%, RT 19.3%, MT 88.5%). Our findings suggest multiple approaches can achieve rapid control of T. solium transmission.. en_US
dc.language.iso eng
dc.publisher Centers for Disease Control and Prevention
dc.relation.ispartofseries Emerging Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Geographically Targeted Interventions en_US
dc.subject Mass Drug Administration en_US
dc.subject Taenia solium Cysticercosis en_US
dc.subject Peru en_US
dc.title Geographically targeted interventions versus mass drug administration to control Taenia solium cysticercosis, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3201/eid2709.203349
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1080-6059


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