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HLA-DR marks recently divided antigen-specific effector CD4 T cells in active tuberculosis patients

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dc.contributor.author Tippalagama, Rashmi
dc.contributor.author Singhania, Akul
dc.contributor.author Dubelko, Paige
dc.contributor.author Lindestam-Arlehamn, Cecilia S.
dc.contributor.author Crinklaw, Austin
dc.contributor.author Pomaznoy, Mikhail
dc.contributor.author Seumois, Gregory
dc.contributor.author deSilva, Aruna D.
dc.contributor.author Premawansa, Sunil
dc.contributor.author Vidanagama, Dhammika
dc.contributor.author Gunasena, Bandu
dc.contributor.author Goonawardhana, N.D.Suraj
dc.contributor.author Ariyaratne, Dinuka
dc.contributor.author Scriba, Thomas J.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Saito, Mayuko
dc.contributor.author Taplitz, Randy
dc.contributor.author Vijayanand, Pandurangan
dc.contributor.author Sette, Alessandro
dc.contributor.author Peters, Bjoern
dc.contributor.author Burel, Julie G.
dc.date.accessioned 2021-10-04T23:00:58Z
dc.date.available 2021-10-04T23:00:58Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9837
dc.description.abstract Upon Ag encounter, T cells can rapidly divide and form an effector population, which plays an important role in fighting acute infections. In humans, little is known about the molecular markers that distinguish such effector cells from other T cell populations. To address this, we investigated the molecular profile of T cells present in individuals with active tuberculosis (ATB), where we expect Ag encounter and expansion of effector cells to occur at higher frequency in contrast to Mycobacterium tuberculosis-sensitized healthy IGRA+ individuals. We found that the frequency of HLA-DR+ cells was increased in circulating CD4 T cells of ATB patients, and was dominantly expressed in M. tuberculosis Ag-specific CD4 T cells. We tested and confirmed that HLA-DR is a marker of recently divided CD4 T cells upon M. tuberculosis Ag exposure using an in vitro model examining the response of resting memory T cells from healthy IGRA+ to Ags. Thus, HLA-DR marks a CD4 T cell population that can be directly detected ex vivo in human peripheral blood, whose frequency is increased during ATB disease and contains recently divided Ag-specific effector T cells. These findings will facilitate the monitoring and study of disease-specific effector T cell responses in the context of ATB and other infections en_US
dc.language.iso eng
dc.publisher American Association of Immunologists
dc.relation.ispartofseries Journal of Immunology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject HLA-DR en_US
dc.subject Antigen en_US
dc.subject CD4 T en_US
dc.subject Cell en_US
dc.subject Tuberculosis en_US
dc.subject Patients en_US
dc.title HLA-DR marks recently divided antigen-specific effector CD4 T cells in active tuberculosis patients en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4049/jimmunol.2100011
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03
dc.relation.issn 1550-6606


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