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Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans

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dc.contributor.author Kehdy, Fernanda S. G.
dc.contributor.author Pita-Oliveira, Murilo
dc.contributor.author Scudeler, Mariana M.
dc.contributor.author Torres-Loureiro, Sabrina
dc.contributor.author Zolini, Camila
dc.contributor.author Moreira, Rennan
dc.contributor.author Michelin, Lucas A.
dc.contributor.author Alvim, Isabela
dc.contributor.author Silva-Carvalho, Carolina
dc.contributor.author Furlan, Vinicius C.
dc.contributor.author Aquino, Marla M.
dc.contributor.author Santolalla Robles, Meddly Leslye
dc.contributor.author Borda, Victor
dc.contributor.author Soares-Souza, Giordano B.
dc.contributor.author Jaramillo-Valverde, Luis
dc.contributor.author Vasquez-Dominguez, Andres
dc.contributor.author Neira, Cesar Sanchez
dc.contributor.author Aguiar, Renato S.
dc.contributor.author Verdugo, Ricardo A.
dc.contributor.author O Connor, Timothy D.
dc.contributor.author Guio, Heinner
dc.contributor.author Tarazona-Santos, Eduardo
dc.contributor.author Leal, Thiago P.
dc.contributor.author Rodrigues-Soares, Fernanda
dc.date.accessioned 2021-10-04T23:00:58Z
dc.date.available 2021-10-04T23:00:58Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9839
dc.description.abstract For human/SARS-CoV-2 interactome genes ACE2, TMPRSS2 and BSG, there is a convincing evidence of association in Asians with influenza-induced SARS for TMPRSS2-rs2070788, tag-SNP of the eQTL rs383510. This case illustrates the importance of population genetics and of sequencing data in the design of genetic association studies in different human populations: the high linkage disequilibrium (LD) between rs2070788 and rs383510 is Asian-specific. Leveraging on a combination of genotyping and sequencing data for Native Americans (neglected in genetic studies), we show that while their frequencies of the Asian tag-SNP rs2070788 is, surprisingly, the highest worldwide, it is not in LD with the eQTL rs383510, that therefore, should be directly genotyped in genetic association studies of SARS in populations with Native American ancestry en_US
dc.language.iso eng
dc.publisher Brazilian Society of Genetics
dc.relation.ispartofseries Genetics and Molecular Biology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject TMPRSS2 en_US
dc.subject ACE2 en_US
dc.subject Native Americans en_US
dc.subject SARS-CoV-2 en_US
dc.subject population genomics en_US
dc.title Human-SARS-CoV-2 interactome and human genetic diversity: TMPRSS2-rs2070788, associated with severe influenza, and its population genetics caveats in Native Americans en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1590/1678-4685-GMB-2020-0484
dc.relation.issn 1678-4685


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