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Manipulating the exposome to enable better ageing

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dc.contributor.author Shiels, Paul G.
dc.contributor.author Painer, Johanna
dc.contributor.author Natterson-Horowitz, Barbara
dc.contributor.author Johnson, Richard J.
dc.contributor.author Miranda, J. Jaime
dc.contributor.author Stenvinkel, Peter
dc.date.accessioned 2021-10-04T23:00:58Z
dc.date.available 2021-10-04T23:00:58Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9849
dc.description.abstract The sum total of life course exposures creates an exposome that has a significant impact on age-related health. Understanding the interplay between exposome factors and the (epi) genome, offers pertinent insights into the ageing process and its relationship with the accumulation of allostatic load. We propose to exploit this to develop a biomimetic approach that will provide insight into how evolution through natural selection in other species has solved many age related human health issues. In particular, we will emphasise the need to reconnect a more mechanistic approach to medical science with a broader natural sciences approach, using biomimetics to mitigate the global burden of age related ill health. In particular, we will discuss how such an approach indicates leverage of the activities of the Nrf 2 gene to enhance health span via reintroduction of the classical 'Food as Medicine' concept, including modulation of the microbiome and the creation of more salutogenic and biophilic environments. Additionally, we will discuss how this approach integrates with novel and developing senotherapies en_US
dc.language.iso eng
dc.publisher Portland Press
dc.relation.ispartofseries Biochemical Journal
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject ageing en_US
dc.subject allostatic load en_US
dc.subject biomimetics en_US
dc.subject exposome en_US
dc.subject microbiome en_US
dc.subject Nrf2 en_US
dc.title Manipulating the exposome to enable better ageing en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1042/BCJ20200958
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.relation.issn 1470-8728


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