Universidad Peruana Cayetano Heredia
Manipulating the exposome to enable better ageing
JavaScript is disabled for your browser. Some features of this site may not work without it.
Mostrar el registro sencillo del ítem
| dc.contributor.author | Shiels, Paul G. | |
| dc.contributor.author | Painer, Johanna | |
| dc.contributor.author | Natterson-Horowitz, Barbara | |
| dc.contributor.author | Johnson, Richard J. | |
| dc.contributor.author | Miranda, J. Jaime | |
| dc.contributor.author | Stenvinkel, Peter | |
| dc.date.accessioned | 2021-10-04T23:00:58Z | |
| dc.date.available | 2021-10-04T23:00:58Z | |
| dc.date.issued | 2021 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/9849 | |
| dc.description.abstract | The sum total of life course exposures creates an exposome that has a significant impact on age-related health. Understanding the interplay between exposome factors and the (epi) genome, offers pertinent insights into the ageing process and its relationship with the accumulation of allostatic load. We propose to exploit this to develop a biomimetic approach that will provide insight into how evolution through natural selection in other species has solved many age related human health issues. In particular, we will emphasise the need to reconnect a more mechanistic approach to medical science with a broader natural sciences approach, using biomimetics to mitigate the global burden of age related ill health. In particular, we will discuss how such an approach indicates leverage of the activities of the Nrf 2 gene to enhance health span via reintroduction of the classical 'Food as Medicine' concept, including modulation of the microbiome and the creation of more salutogenic and biophilic environments. Additionally, we will discuss how this approach integrates with novel and developing senotherapies | en_US |
| dc.language.iso | eng | |
| dc.publisher | Portland Press | |
| dc.relation.ispartofseries | Biochemical Journal | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | ageing | en_US |
| dc.subject | allostatic load | en_US |
| dc.subject | biomimetics | en_US |
| dc.subject | exposome | en_US |
| dc.subject | microbiome | en_US |
| dc.subject | Nrf2 | en_US |
| dc.title | Manipulating the exposome to enable better ageing | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1042/BCJ20200958 | |
| dc.relation.issn | 1470-8728 |
Ficheros en el ítem
| Ficheros | Tamaño | Formato | Ver |
|---|---|---|---|
|
No hay ficheros asociados a este ítem. |
|||
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
Artículos en revistas indizadas [4988]
Recuperados de bases de datos bibliográficas
Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess
