Mortality in parenchymal and subarachnoid neurocysticercosis

Pretell, E. Javier; Gonzales, Isidro; García Lescano, Héctor Hugo; Blanco, D.; Bustos Palomino, Javier Arturo; Abanto, Jesús; Cysticercosis Working Group in Peru; Saavedra Pastor, Herbert; Siu, Diego

dc.contributor.author	Abanto, Jesús
dc.contributor.author	Blanco, D.
dc.contributor.author	Saavedra Pastor, Herbert
dc.contributor.author	Gonzales, Isidro
dc.contributor.author	Siu, Diego
dc.contributor.author	Pretell, E. Javier
dc.contributor.author	Bustos Palomino, Javier Arturo
dc.contributor.author	García Lescano, Héctor Hugo
dc.contributor.author	Cysticercosis Working Group in Peru
dc.date.accessioned	2021-10-04T23:00:59Z
dc.date.available	2021-10-04T23:00:59Z
dc.date.issued	2021
dc.identifier.uri	https://hdl.handle.net/20.500.12866/9855
dc.description.abstract	Neurocysticercosis (NCC) is endemic in many parts of the world, carrying significant neurological morbidity that varies according to whether lesions are located inside the cerebral parenchyma or in extraparenchymal spaces. The latter, in particular subarachnoid NCC, is assumed to be more severe, but no controlled studies comparing mortality between types of NCC exist. The aim of this study was to compare all-cause mortality between patients with intraparenchymal NCC and those with subarachnoid NCC. Vital status and sociodemographic characteristics were evaluated in patients with intraparenchymal viable, intraparenchymal calcified, and subarachnoid NCC attending a neurological referral hospital in Lima, Perú. Survival analyses using Kaplan-Meier curves and Cox proportional regression models were carried out to compare mortality rates between groups. From 840 NCC patients followed by a median time of 82.3 months, 42 (5.0%) died, six (1.8%) in the intraparenchymal viable group, four (1.3%) in the calcified group, and 32 (16.6%) in the subarachnoid group (P < 0.001). Older age and lower education were significantly associated with mortality. The age-adjusted hazard ratio for death in the subarachnoid group was 13.6 (95% CI: 5.6-33.0, P < 0.001) compared with the intraparenchymal viable group and 10.7 (95% CI: 3.7-30.8, P < 0.001) when compared with the calcified group. We concluded that subarachnoid disease is associated with a much higher mortality in NCC	en_US
dc.language.iso	eng
dc.publisher	American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries	American Journal of Tropical Medicine and Hygiene (ASTMH Journal)
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	adult	en_US
dc.subject	age	en_US
dc.subject	all cause mortality	en_US
dc.subject	Article	en_US
dc.subject	calcified parenchymal neurocysticercosis	en_US
dc.subject	cohort analysis	en_US
dc.subject	controlled study	en_US
dc.subject	demography	en_US
dc.subject	educational status	en_US
dc.subject	female	en_US
dc.subject	follow up	en_US
dc.subject	hazard ratio	en_US
dc.subject	human	en_US
dc.subject	Kaplan Meier method	en_US
dc.subject	major clinical study	en_US
dc.subject	male	en_US
dc.subject	mortality rate	en_US
dc.subject	neurocysticercosis	en_US
dc.subject	nonhuman	en_US
dc.subject	Peru	en_US
dc.subject	proportional hazards model	en_US
dc.subject	subarachnoid neurocysticercosis	en_US
dc.subject	survival analysis	en_US
dc.subject	viable parenchymal neurocysticercosis	en_US
dc.title	Mortality in parenchymal and subarachnoid neurocysticercosis	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.4269/ajtmh.20-1330
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn	1476-1645