dc.contributor.author |
Jewell, Paul D. |
|
dc.contributor.author |
Abraham, Annette |
|
dc.contributor.author |
Schmidt, Veronika |
|
dc.contributor.author |
Buell, Kevin G. |
|
dc.contributor.author |
Bustos Palomino, Javier Arturo |
|
dc.contributor.author |
García Lescano, Héctor Hugo |
|
dc.contributor.author |
Dixon, Matthew A. |
|
dc.contributor.author |
Walker, Martin |
|
dc.contributor.author |
Ngowi, Bernard J. |
|
dc.contributor.author |
Basanez, Maria-Gloria |
|
dc.contributor.author |
Winkler, Andrea S. |
|
dc.date.accessioned |
2021-10-04T23:00:59Z |
|
dc.date.available |
2021-10-04T23:00:59Z |
|
dc.date.issued |
2021 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/9862 |
|
dc.description.abstract |
Objectives Neurocysticercosis (NCC) and human immunodeficiency virus (HIV) have a high disease burden and are prevalent in overlapping low- and middle-income areas. Yet, treatment guidance for people living with HIV/AIDS (PLWH/A) co-infected with NCC is currently lacking. This study aims to scope the available literature on HIV/AIDS and NCC co-infection, focusing on epidemiology, clinical characteristics, diagnostics and treatment outcomes. Methods The scoping literature review methodological framework, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. A total of 16,969 records identified through database searching, and 45 additional records from other sources were reduced to 52 included studies after a standardised selection process. Results Two experimental studies, ten observational studies, 23 case series/case reports and 17 reviews or letters were identified. Observational studies demonstrated similar NCC seroprevalence in PLWH/A and their HIV-negative counterparts. Of 29 PLWH/A and NCC co-infection, 17 (59%) suffered from epileptic seizures, 15 (52%) from headaches and 15 (52%) had focal neurological deficits. Eighteen (62%) had viable vesicular cysts, and six (21%) had calcified cysts. Fifteen (52%) were treated with albendazole, of which 11 (73%) responded well to treatment. Five individuals potentially demonstrated an immune-reconstitution inflammatory syndrome after commencing antiretroviral therapy, although this was in the absence of immunological and neuroimaging confirmation. Conclusions There is a paucity of evidence to guide treatment of PLWH/A and NCC co-infection. There is a pressing need for high-quality studies in this patient group to appropriately inform diagnostic and management guidelines for HIV-positive patients with NCC |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Wiley |
|
dc.relation.ispartofseries |
Tropical Medicine and International Health |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
AIDS |
en_US |
dc.subject |
co-infection |
en_US |
dc.subject |
HIV |
en_US |
dc.subject |
neurocysticercosis |
en_US |
dc.subject |
Taenia solium |
en_US |
dc.subject |
taeniosis |
en_US |
dc.title |
Neurocysticercosis and HIV/AIDS co-infection: A scoping review |
en_US |
dc.type |
info:eu-repo/semantics/review |
|
dc.identifier.doi |
https://doi.org/10.1111/tmi.13652 |
|
dc.relation.issn |
1365-3156 |
|