Universidad Peruana Cayetano Heredia

Neurocysticercosis and HIV/AIDS co-infection: A scoping review

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dc.contributor.author Jewell, Paul D.
dc.contributor.author Abraham, Annette
dc.contributor.author Schmidt, Veronika
dc.contributor.author Buell, Kevin G.
dc.contributor.author Bustos Palomino, Javier Arturo
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author Dixon, Matthew A.
dc.contributor.author Walker, Martin
dc.contributor.author Ngowi, Bernard J.
dc.contributor.author Basanez, Maria-Gloria
dc.contributor.author Winkler, Andrea S.
dc.date.accessioned 2021-10-04T23:00:59Z
dc.date.available 2021-10-04T23:00:59Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9862
dc.description.abstract Objectives Neurocysticercosis (NCC) and human immunodeficiency virus (HIV) have a high disease burden and are prevalent in overlapping low- and middle-income areas. Yet, treatment guidance for people living with HIV/AIDS (PLWH/A) co-infected with NCC is currently lacking. This study aims to scope the available literature on HIV/AIDS and NCC co-infection, focusing on epidemiology, clinical characteristics, diagnostics and treatment outcomes. Methods The scoping literature review methodological framework, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. A total of 16,969 records identified through database searching, and 45 additional records from other sources were reduced to 52 included studies after a standardised selection process. Results Two experimental studies, ten observational studies, 23 case series/case reports and 17 reviews or letters were identified. Observational studies demonstrated similar NCC seroprevalence in PLWH/A and their HIV-negative counterparts. Of 29 PLWH/A and NCC co-infection, 17 (59%) suffered from epileptic seizures, 15 (52%) from headaches and 15 (52%) had focal neurological deficits. Eighteen (62%) had viable vesicular cysts, and six (21%) had calcified cysts. Fifteen (52%) were treated with albendazole, of which 11 (73%) responded well to treatment. Five individuals potentially demonstrated an immune-reconstitution inflammatory syndrome after commencing antiretroviral therapy, although this was in the absence of immunological and neuroimaging confirmation. Conclusions There is a paucity of evidence to guide treatment of PLWH/A and NCC co-infection. There is a pressing need for high-quality studies in this patient group to appropriately inform diagnostic and management guidelines for HIV-positive patients with NCC en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Tropical Medicine and International Health
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject AIDS en_US
dc.subject co-infection en_US
dc.subject HIV en_US
dc.subject neurocysticercosis en_US
dc.subject Taenia solium en_US
dc.subject taeniosis en_US
dc.title Neurocysticercosis and HIV/AIDS co-infection: A scoping review en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1111/tmi.13652
dc.relation.issn 1365-3156


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