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dc.contributor.author | Jewell, Paul D. | |
dc.contributor.author | Abraham, Annette | |
dc.contributor.author | Schmidt, Veronika | |
dc.contributor.author | Buell, Kevin G. | |
dc.contributor.author | Bustos Palomino, Javier Arturo | |
dc.contributor.author | García Lescano, Héctor Hugo | |
dc.contributor.author | Dixon, Matthew A. | |
dc.contributor.author | Walker, Martin | |
dc.contributor.author | Ngowi, Bernard J. | |
dc.contributor.author | Basanez, Maria-Gloria | |
dc.contributor.author | Winkler, Andrea S. | |
dc.date.accessioned | 2021-10-04T23:00:59Z | |
dc.date.available | 2021-10-04T23:00:59Z | |
dc.date.issued | 2021 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/9862 | |
dc.description.abstract | Objectives Neurocysticercosis (NCC) and human immunodeficiency virus (HIV) have a high disease burden and are prevalent in overlapping low- and middle-income areas. Yet, treatment guidance for people living with HIV/AIDS (PLWH/A) co-infected with NCC is currently lacking. This study aims to scope the available literature on HIV/AIDS and NCC co-infection, focusing on epidemiology, clinical characteristics, diagnostics and treatment outcomes. Methods The scoping literature review methodological framework, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. A total of 16,969 records identified through database searching, and 45 additional records from other sources were reduced to 52 included studies after a standardised selection process. Results Two experimental studies, ten observational studies, 23 case series/case reports and 17 reviews or letters were identified. Observational studies demonstrated similar NCC seroprevalence in PLWH/A and their HIV-negative counterparts. Of 29 PLWH/A and NCC co-infection, 17 (59%) suffered from epileptic seizures, 15 (52%) from headaches and 15 (52%) had focal neurological deficits. Eighteen (62%) had viable vesicular cysts, and six (21%) had calcified cysts. Fifteen (52%) were treated with albendazole, of which 11 (73%) responded well to treatment. Five individuals potentially demonstrated an immune-reconstitution inflammatory syndrome after commencing antiretroviral therapy, although this was in the absence of immunological and neuroimaging confirmation. Conclusions There is a paucity of evidence to guide treatment of PLWH/A and NCC co-infection. There is a pressing need for high-quality studies in this patient group to appropriately inform diagnostic and management guidelines for HIV-positive patients with NCC | en_US |
dc.language.iso | eng | |
dc.publisher | Wiley | |
dc.relation.ispartofseries | Tropical Medicine and International Health | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | AIDS | en_US |
dc.subject | co-infection | en_US |
dc.subject | HIV | en_US |
dc.subject | neurocysticercosis | en_US |
dc.subject | Taenia solium | en_US |
dc.subject | taeniosis | en_US |
dc.title | Neurocysticercosis and HIV/AIDS co-infection: A scoping review | en_US |
dc.type | info:eu-repo/semantics/review | |
dc.identifier.doi | https://doi.org/10.1111/tmi.13652 | |
dc.relation.issn | 1365-3156 |
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