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Prevalence and clinical outcomes of pleural effusion in COVID-19 patients: A systematic review and meta-analysis.

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dc.contributor.author Rathore, Sawai Singh
dc.contributor.author Hussain, Nabeel
dc.contributor.author Manju, Ade Harrison
dc.contributor.author Wen, Qingqing
dc.contributor.author Tousif, Sohaib
dc.contributor.author Avendano-Capriles, Camilo Andres
dc.contributor.author Hernandez-Woodbine, Maria Jose
dc.contributor.author Rojas, Gianpier Alonzo
dc.contributor.author Vatsavayi, Priyanka
dc.contributor.author Tera, Chenna Reddy
dc.contributor.author Ali, Muhammad Adnan
dc.contributor.author Singh, Romil
dc.contributor.author Saleemi, Shayan
dc.contributor.author Patel, Deep Manojkumar
dc.date.accessioned 2021-10-04T23:01:00Z
dc.date.available 2021-10-04T23:01:00Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9873
dc.description.abstract Observational studies indicate that pleural effusion has an association with risk and the clinical prognosis of COVID-19 disease; however, the available literature on this area is inconsistent. The objective of this systematic review and meta-analysis is to evaluate the correlation between COVID-19 disease and pleural effusion. A rigorous literature search was conducted using multiple databases. All eligible observational studies were included from around the globe. The pooled prevalence and associated 95% confidence interval (CI) were calculated using the random effect model. Mantel-Haenszel odds ratios were produced to report overall effect size using random effect models for severity and mortality outcomes. Funnel plots, Egger regression tests, and Begg-Mazumdar's rank correlation test were used to appraise publication bias. Data from 23 studies including 6234 COVID-19 patients was obtained. The overall prevalence of pleural effusion in COVID-19 patients was 9.55% (95% CI, I2 =92%). Our findings also indicated that the presence of pleural effusions associated with increased risk of severity of disease(OR=5.08, 95% CI 3.14-8.22, I2 =77.4%) and mortality due to illness(OR=4.53, 95% CI 2.16-9.49, I2 =66%) compared with patients without pleural effusion. Sensitivity analyses illustrated a similar effect size while decreasing the heterogeneity. No significant publication bias was evident in the meta-analysis. The presence of pleural effusion can assist as a prognostic factor to evaluate the risk of worse outcomes in COVID-19 patients hence, it is recommended that hospitalized COVID-19 patients with pleural effusion should be managed on an early basis en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Journal of Medical Virology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject COVID-19 en_US
dc.subject pleural effusion en_US
dc.subject SARS-CoV-2 en_US
dc.subject X-ray computed tomography en_US
dc.subject viral en_US
dc.subject pleural disease en_US
dc.title Prevalence and clinical outcomes of pleural effusion in COVID-19 patients: A systematic review and meta-analysis. en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1002/jmv.27301
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.02
dc.relation.issn 1096-9071


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