Universidad Peruana Cayetano Heredia

SARS-CoV-2 seroprevalence and associated factors in Manaus, Brazil: baseline results from the DETECTCoV-19 cohort study

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dc.contributor.author Lalwani, P.
dc.contributor.author Salgado, B.B.
dc.contributor.author Filho, I.V.P.
dc.contributor.author da Silva, D.S.S.
dc.contributor.author de Morais, T.B.D.N.
dc.contributor.author Jordão, M.F.
dc.contributor.author Barbosa, A.R.C.
dc.contributor.author Cordeiro, I.B.
dc.contributor.author Neto, J.N.D.S.
dc.contributor.author de Assunção, E.N.
dc.contributor.author dos Santos, R.O.
dc.contributor.author Carvalho, N.O.
dc.contributor.author Sobrinho, W.B.S.
dc.contributor.author da Costa, C.F.
dc.contributor.author de Souza, P.E.
dc.contributor.author de Albuquerque, B.C.
dc.contributor.author Ganoza Gallardo, Christian Alejandro
dc.contributor.author Araujo-Castillo, R.V.
dc.contributor.author Filho, S.A.
dc.contributor.author Lalwani, J.D.B.
dc.contributor.author The DETECTCoV-19 Study Team
dc.date.accessioned 2021-10-04T23:01:00Z
dc.date.available 2021-10-04T23:01:00Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9887
dc.description.abstract Background: Manaus, located in the Brazilian rainforest, has experienced two health system collapses due to the coronavirus disease 2019 (COVID-19) pandemic. However, little is known about which groups among the general population have been most affected. Methods: A convenience sampling strategy via online advertising recruited 3046 adults between 19 August 2020 and 2 October 2020. Sociodemographic characteristics, COVID-19-related symptoms, COVID-19 testing, self-medication and prescribed medications were recorded. Serum anti-severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) nucleocapsid immunoglobulin G antibodies were measured with an enzyme-linked immunosorbent assay. Prevalence ratios (PR) were obtained using cluster-corrected and adjusted Poisson's regression models. Results: A crude positivity rate among asymptomatic and symptomatic individuals was estimated at 29.10%, with maximum possible seroprevalence of 44.82% corrected by test characteristics and an antibody decay rate of 32.31%. Regression models demonstrated a strong association towards marginalized low-income and vulnerable residents with limited access to health care. The presence of a COVID-19 case [PR 1.39, 95% confidence interval (CI) 1.24–1.57] or death (PR 2.14, 95% CI 1.74–2.62) in a household greatly increased the risk of other household members acquiring infection. The seroprevalence of SARS-CoV-2 was higher among those who self-medicated to prevent infection (PR 1.36, 95% CI 1.27–1.46). Conclusions: Disproportionate socio-economic disparity was observed among the study participants. The syndemic nature of COVID-19 in the Amazon region needs differential policies and urgent solutions to control the ongoing pandemic en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries International Journal of Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Amazon en_US
dc.subject COVID-19 en_US
dc.subject Epidemiology en_US
dc.subject Risk factors en_US
dc.subject SARS-CoV-2 en_US
dc.subject Seroprevalence en_US
dc.title SARS-CoV-2 seroprevalence and associated factors in Manaus, Brazil: baseline results from the DETECTCoV-19 cohort study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.ijid.2021.07.017
dc.relation.issn 1878-3511


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