Universidad Peruana Cayetano Heredia

The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci

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dc.contributor.author D'Aeth, Joshua C.
dc.contributor.author van der Linden, Mark Pg
dc.contributor.author McGee, Lesley
dc.contributor.author de Lencastre, Herminia
dc.contributor.author Turner, Paul
dc.contributor.author Song, Jae-Hoon
dc.contributor.author Lo, Stephanie W.
dc.contributor.author Gladstone, Rebecca A.
dc.contributor.author Sá-Leão, Raquel
dc.contributor.author Ko, Kwan Soo
dc.contributor.author Hanage, William P.
dc.contributor.author Breiman, Robert F.
dc.contributor.author Beall, Bernard
dc.contributor.author Bentley, Stephen D.
dc.contributor.author Croucher, Nicholas J.
dc.date.accessioned 2021-10-04T23:01:01Z
dc.date.available 2021-10-04T23:01:01Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9902
dc.description.abstract Multidrug-resistant Streptococcus pneumoniae emerge through the modification of core genome loci by interspecies homologous recombinations, and acquisition of gene cassettes. Both occurred in the otherwise contrasting histories of the antibiotic-resistant S. pneumoniae lineages PMEN3 and PMEN9. A single PMEN3 clade spread globally, evading vaccine-induced immunity through frequent serotype switching, whereas locally circulating PMEN9 clades independently gained resistance. Both lineages repeatedly integrated Tn916-type and Tn1207.1-type elements, conferring tetracycline and macrolide resistance, respectively, through homologous recombination importing sequences originating in other species. A species-wide dataset found over 100 instances of such interspecific acquisitions of resistance cassettes and flanking homologous arms. Phylodynamic analysis of the most commonly sampled Tn1207.1-type insertion in PMEN9, originating from a commensal and disrupting a competence gene, suggested its expansion across Germany was driven by a high ratio of macrolide-to-β-lactam consumption. Hence, selection from antibiotic consumption was sufficient for these atypically large recombinations to overcome species boundaries across the pneumococcal chromosome en_US
dc.language.iso eng
dc.publisher eLife Sciences Publications
dc.relation.ispartofseries eLife
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject epidemiology en_US
dc.subject genetics en_US
dc.subject infectious disease en_US
dc.subject AMR en_US
dc.subject genomics en_US
dc.subject microbiology en_US
dc.subject recombination en_US
dc.subject streptococcus pneumoniae en_US
dc.title The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.7554/eLife.67113
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.04
dc.relation.issn 2050-084X


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