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Triclabendazole Treatment Failure for Fasciola hepatica Infection among Preschool and School Age Children, Cusco, Peru

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dc.contributor.author Morales Fernández, María Luisa
dc.contributor.author Tanabe, Melinda B.
dc.contributor.author White, A. Clinton, Jr.
dc.contributor.author Lopez, Martha
dc.contributor.author Bascope, Ruben
dc.contributor.author Cabada, Miguel M.
dc.date.accessioned 2021-10-04T23:01:01Z
dc.date.available 2021-10-04T23:01:01Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9904
dc.description.abstract We conducted a retrospective cohort study of children who had chronic fascioliasis in the highlands of Peru to determine triclabendazole treatment efficacy. Children passing Fasciola eggs in stool were offered directly observed triclabendazole treatment (>= 1 doses of 10 mg/kg). Parasitologic cure was evaluated by using microscopy of stool 1-4 months after each treatment. A total of 146 children who had chronic fascioliasis participated in the study; 53% were female, and the mean +/- SD age was 10.4 +/- 3.1 years. After the first treatment, 55% of the children achieved parasitologic cure. Cure rates decreased after the second (38%), third (30%), and fourth (23%) treatments; 17 children (11.6%) did not achieve cure after 4 treatments. Higher baseline egg counts and lower socioeconomic status were associated with triclabendazole treatment failure. Decreased triclabendazole efficacy in disease-endemic communities threatens control efforts. Further research on triclabendazole resistance and new drugs to overcome it are urgently needed en_US
dc.language.iso eng
dc.publisher Centers for Disease Control and Prevention
dc.relation.ispartofseries Emerging Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Triclabendazole en_US
dc.subject Fasciola hepatica en_US
dc.subject Infection en_US
dc.subject Preschool Children en_US
dc.subject School-Age Children en_US
dc.subject Cusco en_US
dc.subject Peru en_US
dc.title Triclabendazole Treatment Failure for Fasciola hepatica Infection among Preschool and School Age Children, Cusco, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3201/eid2707.203900
dc.relation.issn 1080-6059


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