Universidad Peruana Cayetano Heredia

Viral intra-host evolution in immunocompetent children contributes to human norovirus diversification at the global scale.

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dc.contributor.author Tohma, Kentaro
dc.contributor.author Saito, Mayuko
dc.contributor.author Pajuelo Travezaño, Monica Jhenny
dc.contributor.author Mayta, Holger
dc.contributor.author Zimic-Peralta, Mirko Juan
dc.contributor.author Lepore, Cara J
dc.contributor.author Ford-Siltz, Lauren A
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Parra, Gabriel I
dc.date.accessioned 2021-10-04T23:01:01Z
dc.date.available 2021-10-04T23:01:01Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9909
dc.description.abstract Norovirus is a major cause of acute gastroenteritis. Human noroviruses present >30 different genotypes, with a single genotype (GII.4) predominating worldwide. Concurrent outbreaks of norovirus are often associated with the emergence of new viruses. While different hypotheses have been presented, the source of new mutations in noroviruses is still unknown. In this study, we applied high-resolution sequencing to determine the intra-host viral diversity presented by noroviruses during the acute and shedding phase of infection in children. Profiling viral intra-host diversification at nearly full genome level indicated that GII.4 viruses presented dynamic intra-host variation, while non-GII.4 viruses presented minimal variation throughout the infection. Notably, the intra-host genetic variation during the shedding phase recapitulates the genetic diversity observed at the global level, particularly those mapping at the VP1 antigenic sites. Thus the intra-host evolution in healthy children explains the source of norovirus mutations that results in diversification at the global scale en_US
dc.language.iso eng
dc.publisher Taylor and Francis
dc.relation.ispartofseries Emerging Microbes and Infections
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Calicivirus en_US
dc.subject norovirus en_US
dc.subject evolution en_US
dc.subject intra-host evolution en_US
dc.subject immunocompetent en_US
dc.subject gastrointestinal infection en_US
dc.title Viral intra-host evolution in immunocompetent children contributes to human norovirus diversification at the global scale. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1080/22221751.2021.1967706
dc.relation.issn 2222-1751


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