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Browsing by Author "Llanos Cuentas, Elmer Alejandro"

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Acceptability of a herd immunity-focused, transmission-blocking malaria vaccine in malaria-endemic communities in the Peruvian Amazon: an exploratory study

White, Sara E.; Harvey, Steven A.; Meza, Graciela; Llanos Cuentas, Elmer Alejandro; Guzman Guzman, Mitchel Anthony; Gamboa Vilela, Dionicia Baziliza; Vinetz, Joseph Michael (BioMed Central, 2018)

BACKGROUND: A transmission-blocking vaccine (TBV) to prevent malaria-infected humans from infecting mosquitoes has been increasingly considered as a tool for malaria control and elimination. This study tested the hypothesis ...
Accurate and rapid species typing from cutaneous and mucocutaneous leishmaniasis lesions of the New World

Fraga, J.; Veland, N.; Montalvo, A.M.; Praet, N.; Boggild, A.K.; Valencia, B.M.; Arévalo Zelada, Jorge Luis; Llanos Cuentas, Elmer Alejandro; Dujardin, J.-C.; Van der Auwera, G. (Elsevier, 2012)

The heat-shock protein 70 gene (hsp70) has been exploited for Leishmania species identification in the Old and New World, using polymerase chain reaction (PCR) followed by restriction fragment length polymorphism analysis. ...
Aceptabilidad de pre-escolares y escolares a la proteína purificada de pescado en polvo

Bullón Vela, Vanessa; Valdiviezo Villacorta, Gladys Victoria; Baiocchi, Nelly; Campos, Miguel; Llanos Cuentas, Elmer Alejandro; Ochoa Woodell, Theresa Jean (Instituto Nacional de Salud, 2018)

Objetivos. Determinar la aceptabilidad de la proteína purificada de pescado (FPi) en bebidas a base de cereales y pseudocereales. Materiales y Métodos. El estudio se realizó en el Centro de Desarrollo Integral Familiar ...
Alteraciones electrocardiográficas en pacientes mayores de 40 años con leishmaniasis tegumentaria en tratamiento con antimoniales pentavalentes

Toribio Orbegozo, Pedro Angel; Vera Casas, Rubi Maribel; Nizama Zevallos, Luis Alberto (Universidad Peruana Cayetano HerediaPE, 2021)

Antecedentes: Los antimoniales pentavalentes aún son el tratamiento de primera línea para leishmaniasis tegumentaria, a pesar de ser cardiotóxicos. Existen pocos estudios sobre alteraciones electrocardiográficas en pacientes ...
Anemia in infancy is associated with alterations in systemic metabolism and microbial structure and function in a sex-specific manner: an observational study

McClorry, Shannon; Zavaleta, Nelly; Llanos Cuentas, Elmer Alejandro; Casapía, Martin; Lönnerdal, Bo; Slupsky, Carolyn M. (Oxford University Press, 2018)

Background: Anemia is a term that describes low hemoglobin concentrations and can result from micronutrient deficiencies, infection, or low birth weight. Early-life anemia, particularly iron-deficiency anemia (IDA) is ...
Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study

Llanos Cuentas, Elmer Alejandro; Casapia, Martin; Chuquiyauri, Raúl; Hinojosa, Juan-Carlos; Kerr, Nicola; Rosario, Maria; Toovey, Stephen; Arch, Robert H.; Phillips, Margaret A.; Rozenberg, Felix D.; Bath, Jade; Ng, Caroline L.; Cowell, Annie N.; Winzeler, Elizabeth A.; Fidock, David A.; Baker, Mark; Möhrle, Jörg J.; Hooft van Huijsduijnen, Rob; Gobeau, Nathalie; Araeipour, Nada; Andenmatten, Nicole; Rückle, Thomas; Duparc, Stephan (Elsevier, 2018)

BACKGROUND: DSM265 is a novel, long-duration inhibitor of plasmodium dihydroorotate dehydrogenase (DHODH) with excellent selectivity over human DHODH and activity against blood and liver stages of Plasmodium falciparum. ...
Anti–MSP-10 IgG indicates recent exposure to Plasmodium vivax infection in the Peruvian Amazon

Rosas-Aguirre, A.; Patra, K.P.; Calderón Sánchez, Maritza Mercedes; Torres Fajardo, Katherine Jessica; Gamboa Vilela, Dionicia Baziliza; Arocutipa, E.; Málaga, E.; Garro, K.; Fernández, C.; Trompeter, G.; Alnasser, Y.; Llanos Cuentas, Elmer Alejandro; Gilman, Robert Hugh; Vinetz, Joseph Michael (American Society for Clinical Investigation, 2020)

BACKGROUND. Serological tools for the accurate detection of recent malaria exposure are needed to guide and monitor malaria control efforts. IgG responses against Plasmodium vivax and P. falciparum merozoite surface ...
Assessing malaria transmission in a low endemicity area of north-western Peru

Rosas-Aguirre, Angel; Llanos Cuentas, Elmer Alejandro; Speybroeck, Niko; Cook, Jackie; Contreras-Mancilla, Juan; Soto, Veronica; Gamboa Vilela, Dionicia Baziliza; Pozo, Edwar; Ponce, Oscar J.; Pereira, Mayne O.; Soares, Irene S.; Theisen, Michael; D'Alessandro, Umberto; Erhart, Annette (BioMed Central, 2013)

Background: Where malaria endemicity is low, control programmes need increasingly sensitive tools for monitoring malaria transmission intensity (MTI) and to better define health priorities. A cross-sectional survey was ...
An association between phlebotomine sandflies and aphids in the Peruvian Andes

Cameron, Mary M.; Milligan, Paul J.M.; Llanos Cuentas, Elmer Alejandro; Davies, Clive Richard (Wiley, 1995)

As the composition of natural sugars in the diet of adult sandflies (Diptera: Psychodidae: Phlebotominae) may affect the development of Leishmania (Kinetoplastida: Trypanosomatidae) in sandfly guts, and so play an important ...
Association of the Endobiont Double-Stranded RNA Virus LRV1 With Treatment Failure for Human Leishmaniasis Caused by Leishmania braziliensis in Peru and Bolivia

Adaui, Vanessa; Lye, Lon-Fye; Akopyants, Natalia S.; Zimic-Peralta, Mirko Juan; Llanos Cuentas, Elmer Alejandro; Garcia, Lineth; Maes, Ilse; De Doncker, Simonne; Dobson, Deborah E.; Arévalo Zelada, Jorge Luis; Dujardin, Jean-Claude; Beverley, Stephen M. (Oxford University Press, 2015)

Cutaneous and mucosal leishmaniasis, caused in South America by Leishmania braziliensis, is difficult to cure by chemotherapy (primarily pentavalent antimonials [Sb(V)]). Treatment failure does not correlate well with ...
Biochemical characterization of Leishmania (Viannia) braziliensis and Leishmania (Viannia) peruviana by isoenzyme electrophoresis

Arana, Marlyn; Evans, D. A.; Zolessi, A.; Llanos Cuentas, Elmer Alejandro; Arévalo Zelada, Jorge Luis (Oxford University Press, 1990)

Leishmanial organisms isolated from 24 patients with Andean cutaneous leishmaniais (uta) and from 7 with sylvatic leishmaniasis in both cutaneous and mucosal forms were characterized on the basis of their isoenzyme profiles ...
Características del inicio sexual de hombres que tienen sexo con hombres y mujeres transgénero de alto riesgo en el Perú y su asociación con el comportamiento sexual actual en cinco ciudades del Perú-2011

Pun Chinarro, Mónica Mariella (Universidad Peruana Cayetano HerediaPE, 2015)

Para conocer las características del inicio sexual de hombres que tienen sexo con hombres (HSH) y mujeres transgénero (MTG) de alto riesgo y su asociación con el comportamiento sexual actual en cinco ciudades del Perú, se ...
A Case-Control Study on the Association Between Intestinal Helminth Infections and Treatment Failure in Patients With Cutaneous Leishmaniasis

Martínez, Dalila Y.; Llanos Cuentas, Elmer Alejandro; Dujardin, Jean-Claude; Polman, Katja; Adaui, Vanessa; Boelaert, Marleen; Verdonck, Kristien (Oxford University Press, 2020)

BACKGROUND: Endemic regions of cutaneous leishmaniasis (CL) and intestinal helminthiasis overlap. CL treatment with systemic pentavalent antimonial drugs (Sb(5+)) fails in 10%-30% of patients. The study objective was to ...
Challenges of design, implementation, acceptability, and potential for, biomedical technologies in the Peruvian Amazon

Bressan, Tiana; Valdivia-Gago, Andrea; Silvera Ccallo, Rosa Mercedes; Llanos Cuentas, Elmer Alejandro; Cóndor Camara, Daniel Flavio; Padilla-Huamantinco, Pierre G.; Vilcarromero, Stalin; Miranda, J. Jaime; Zavaleta Cortijo, Claudia Carol (BioMed Central, 2022)

Background: Biomedical technologies have the potential to be advantageous in remote communities. However, information about barriers faced by users of technology in general and in remote Indigenous communities is scarce. ...
Characteristics of Travel-Related Severe Plasmodium vivax and Plasmodium falciparum Malaria in Individuals Hospitalized at a Tertiary Referral Center in Lima, Peru

Llanos-Chea, Fiorella; Martinez, Dalila; Rosas, Angel; Samalvides Cuba, Frine; Vinetz, Joseph Michael; Llanos Cuentas, Elmer Alejandro (American Society of Tropical Medicine and Hygiene, 2015)

Severe Plasmodium falciparum malaria is uncommon in South America. Lima, Peru, while not endemic for malaria, is home to specialized centers for infectious diseases that admit and manage patients with severe malaria (SM), ...
Characterization of Leishmania species from Peru

Romero, G.G.; Arana, Margarita; López, Martin; Montoya, I.; Bohl, R.; Campos Sanchez, Miguel; Arévalo Zelada, Jorge Luis; Llanos Cuentas, Elmer Alejandro (Oxford University Press, 1987)

Twenty-six isolates of Leishmania parasites of Peruvian origin were studied by isoenzyme electrophoresis of four marker enzymes (ASAT, ALAT, G6PD and GPI), kinetoplast DNA hybridization and monoclonal antibody binding and ...
The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: An individual patient data meta-analysis

Watson, James A.; Commons, Robert J.; Tarning, Joel; Simpson, Julie A.; Llanos Cuentas, Elmer Alejandro; Lacerda, Marcus V. G.; Green, Justin A.; Koh, Gavin C. K. W.; Chu, Cindy S.; Nosten, Francois H.; Price, Richard N.; Day, Nicholas P. J.; White, Nicholas J. (eLife Sciences Publications, 2022)

Tafenoquine is a newly licensed antimalarial drug for the radical cure of Plasmodium vivax malaria. The mechanism of action and optimal dosing are uncertain. We pooled individual data from 1102 patients and 72 healthy ...
Comparative activity of phlebotomine sandflies (Diptera: Psychodidae) in different crops in the Peruvian Andes

Cameron, M.M.; Davies, C.R.; Monje, Julio; Villaseca, P.; Ogusuku, E.; Llanos Cuentas, Elmer Alejandro (Cambridge University Press, 1994)

Significant inter-crop variation in the abundance of phlebotomine sandflies, mostly Lutzomyia verrucarum Townsend, and five aphid species (Hemiptera: Aphididae), was demonstrated by repeated castor oil sticky trap collections ...
A Comparative Field Study of the Relative Importance of Lutzomyia peruensis and Lutzomyia verrucarum as Vectors of Cutaneous Leishmaniasis in the Peruvian Andes

Villaseca, P.; Llanos Cuentas, Elmer Alejandro; Perez, E.; Davies, C. R. (American Journal of Tropical Medicine and Hygiene, 1993)

A two-year field study of Andean cutaneous leishmaniasis (uta) in the valley of Purisima, Ancash Department, Peru has provided quantitative epidemiologic and entomologic evidence for the predominant role of Lutzomyia ...
Comparative gene expression analysis throughout the life cycle of Leishmania braziliensis: Diversity of expression profiles among clinical isolates

Adaui, V.; Castillo Pareja, Denis Helan; Zimic-Peralta, Mirko Juan; Gutierrez, Andrés; Decuypere, S.; Vanaerschot, M.; de Doncker, S.; Schnorbusch, K.; Maes, I.; van der Auwera, G.; Maes, L.; Llanos Cuentas, Elmer Alejandro; Arévalo Zelada, Jorge Luis; Dujardin, J.-C. (Public Library of Science, 2011)

Background: Most of the Leishmania genome is reported to be constitutively expressed during the life cycle of the parasite, with a few regulated genes. Inter-species comparative transcriptomics evidenced a low number of ...

Browsing by Author "Llanos Cuentas, Elmer Alejandro"

Browsing by Author "Llanos Cuentas, Elmer Alejandro"

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