Listar por tema "unclassified drug"

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  • Loss of prolyl hydroxylase-2 in myeloid cells and T-lymphocytes impairs tumor development 
    Mamlouk, S.; Kalucka, J.; Singh, R.P.; Franke, K.; Muschter, A.; Langer, A.; Jakob, C.; Gassmann, M.; Baretton, G.B.; Wielockx, B. (Wiley, 2013)
    The tumor microenvironment plays a pivotal role during cancer development and progression. The balance between suppressive and cytotoxic responses of the tumor immune microenvironment has been shown to have a direct effect ...
  • Mechanisms of liver fibrosis associated with experimental fasciola hepatica infection: Roles of Fas2 proteinase and hepatic stellate cell activation 
    Marcos, L.A.; Terashima, A.; Yi, P.; Andrade, R.; Cubero, F.J.; Albanis, E.; Gotuzzo Herencia, José Eduardo; Espinoza, J.R.; Friedman, S.L. (American Society of Parasitologists, 2011)
    We have evaluated the possible mechanisms of liver fibrosis caused by Fasciola hepatica in an animal model and in culture using immortalized human stellate cells. Liver biopsies of F. hepatica-infected rats were performed ...
  • New findings on Simalikalactone D, an antimalarial compound from Quassia amara L. (Simaroubaceae) 
    Bertani, S.; Houël, E.; Jullian, V.; Bourdy, G.; Valentin, A.; Stien, D.; Deharo, E. (Elsevier, 2012)
    Quassia amara L. (Simaroubaceae) is a species widely used as tonic and is claimed to be an efficient antimalarial all over the Northern part of the Amazon basin. Quassinoid compound Simalikalactone D (SkD) has been shown ...
  • New vaccines needed for pathogens infecting animals and humans: One Health 
    Gutiérrez, A.H.; Spero, D.M.; Gay, C.; Zimic-Peralta, Mirko Juan; De Groot, A.S. (Taylor and Francis, 2012)
    The field of "One Health" encourages researchers to collaborate across a wide range of disciplines to improve health at the animal-human- ecosystems interface. One Health recognizes the potential of emerging infectious ...
  • Novel mutations associated with nephrogenic diabetes insipidus. A clinical-genetic study 
    García Castaño, A.; Pérez de Nanclares, G.; Madariaga, L.; Aguirre, M.; Chocron, S.; Madrid, A.; Lafita Tejedor, F.J.; Gil Campos, M.; Sánchez del Pozo, J.; Ruiz Cano, R.; Espino, M.; Gomez Vida, J.M.; Santos, F.; García Nieto, V.M.; Loza, R.; Rodríguez, L.M.; Hidalgo Barquero, E.; Printza, N.; Camacho, J.A.; Castaño, L.; Ariceta, G.; RenalTube Group (Springer, 2015)
    Molecular diagnosis is a useful diagnostic tool in primary nephrogenic diabetes insipidus (NDI), an inherited disease characterized by renal inability to concentrate urine. The AVPR2 and AQP2 genes were screened for mutations ...
  • Oil emulsion from Plukenetia huayllabambana (Sacha inchi) modifies nitric oxide and leptin in the liver and antioxidant and inflammation markers in the adipose tissue in obese rats 
    Ambulay, J.P.; Rojas, P.A.; Timoteo, O.S.; Barreto, T.V.; Vila, Z.N.; de los Santos, M.B.; Eguiluz, M.; Colarossi, A. (Food Science Publisher, 2021)
    Background: Obesity is characterized by excessive accumulation of adipose tissue and is associated with higher risk of metabolic diseases and other comorbidities. Efficacious strategies including a diet high in “functional ...
  • Performance of a sandwich antigen-detection ELISA for the diagnosis of Porcine Taenia solium cysticercosis 
    Bustos Palomino, Javier Arturo; Ninaquispe, B.E.; Rodriguez, S.; Castillo Berrios, Yesenia; Yang, S.Y.; Gilman, Robert Hugh; Dorny, P.; Gabriël, S.; García Lescano, Héctor Hugo; Gonzalez Zariquiey, Armando Emiliano (American Society of Tropical Medicine and Hygiene, 2019)
    The pig is the natural intermediate host of Taenia solium, a parasite causing significant burden of disease in both humans and pigs. Porcine cysticercosis is traditionally detected via tongue palpation and slaughterhouse ...
  • Pharmacokinetics, safety, and tolerability of oxfendazole in healthy volunteers: A randomized, placebo-controlled first-inhuman single-dose escalation study 
    An, G.; Murry, D.J.; Gajurel, K.; Bach, T.; Deye, G.; Stebounova, L.V.; Codd, E.E.; Horton, J.; Gonzalez Zariquiey, Armando Emiliano; García Lescano, Héctor Hugo; Ince, D.; Hodgson-Zingman, D.; Nomicos, E.Y.H.; Conrad, T.; Kennedy, J.; Jones, W.; Gilman, Robert Hugh; Winokur, P. (American Society for Microbiology, 2019)
    Cysticercosis is a parasitic disease that frequently involves the human central nervous system (CNS), and current treatment options are limited. Oxfendazole, a veterinary medicine belonging to the benzimidazole family of ...
  • Phylogenetic relationships of Shiga toxin-producing Escherichia coli isolated from Peruvian children 
    Contreras, C.A.; Ochoa Woodell, Theresa Jean; Ruiz, J.; Lacher, D.W.; Rivera, F.P.; Saenz, Y.; Chea-Woo, E.; Zavaleta, N.; Gil, A.I.; Lanata, C.F.; Huicho Oriundo, Luis; Maves, R.C.; Torres, C.; DebRoy, C.; Cleary, T.G. (Microbiology Society, 2011)
    The aim of this study was to determine the prevalence, virulence factors (stx, eae, ehxA and astA) and phylogenetic relationships [PFGE and multilocus sequence typing (MLST)] of Shiga toxinproducing Escherichia coli (STEC) ...
  • Physangulidine A, a withanolide from Physalis angulata, perturbs the cell cycle and induces cell death by apoptosis in prostate cancer cells 
    Reyes-Reyes, E.M.; Jin, Z.; Vaisberg Wollach, Abraham Jaime; Hammond, G.B.; Bates, P.J. (American Chemical Society, 2013)
    Recently, our group reported the discovery of three new withanolides, physangulidines A–C, from Physalis angulata. In this study, the biological effects of physangulidine A (1), which was the most active and abundant of ...
  • Plasmodium falciparum Field Isolates from South America Use an Atypical Red Blood Cell Invasion Pathway Associated with Invasion Ligand Polymorphisms 
    Lopez-Perez, M.; Villasis Mayuri, Elizabeth Melisa; Machado, R.L.D.; Póvoa, M.M.; Vinetz, Joseph Michael; Blair, S.; Gamboa Vilela, Dionicia Baziliza; Lustigman, S. (Public Library of Science, 2012)
    Studies of Plasmodium falciparum invasion pathways in field isolates have been limited. Red blood cell (RBC) invasion is a complex process involving two invasion protein families; Erythrocyte Binding-Like (EBL) and the ...
  • Polymerase chain reaction detection of leishmania kDNA from the urine of Peruvian patients with cutaneous and mucocutaneous leishmaniasis 
    Veland, N.; Espinosa, D.; Valencia, B.M.; Ramos, A.P.; Calderon, F.; Arévalo Zelada, Jorge Luis; Low, D.E.; Llanos Cuentas, Elmer Alejandro; Boggild, A.K. (American Society of Tropical Medicine and Hygiene, 2011)
    We hypothesized that Leishmania kDNA may be present in urine of patients with cutaneous leishmaniasis (CL). Urine samples and standard diagnostic specimens were collected from patients with skin lesions. kDNA polymerase ...
  • Presumptive tests: A substitute for Benzidine in blood samples recognition 
    Gomes, C.; López-Matayoshi, C.; Palomo-Díez, S.; López-Parra, A. M.; Cuesta-Alvaro, P.; Baeza-Richer, C.; Gibaja, J. F.; Arroyo-Pardo, E. (Elsevier, 2017)
    The nature of the sample in a forensic case is one of the most important factors, since it determines the posterior analysis, helping to define or discard its identity (like blood versus semen). A presumptive test is a ...
  • Protective effect of Chuquiraga spinosa lessing associated with simvastatin on N-Nitroso-N-methylurea (NMU)-induced prostate cancer in rats 
    Arroyo-Acevedo, Jorge Luis; Rojas-Armas, Juan Pedro; Herrera-Calderon, Oscar; Chavez-Asmat, Roberto; Justil-Guerrero, Hugo Jesus; Aguilar-Carranza, Cristian; Enciso-Roca, Edwin; Tinco-Jayo, Johnny Aldo; Yuli-Posadas, Ricardo Angel; Franco-Quino, Cesar; Chumpitaz-Cerrate, Victor (Dove Medical Press, 2019)
    Background and objective: Chuquiraga spinosa Lessing (ChS) has shown protective effect on N-Nitroso-N-methylurea (NMU)-induced prostate cancer in rats. Currently, statins are being studied for their pro-apoptotic and ...
  • A research agenda for helminth diseases of humans: Intervention for control and elimination 
    Prichard, R.K.; Basáñez, M.-G.; Boatin, B.A.; McCarthy, J.S.; García Lescano, Héctor Hugo; Yang, G.-J.; Sripa, B.; Lustigman, S. (Public Library of Science, 2012)
    Recognising the burden helminth infections impose on human populations, and particularly the poor, major intervention programmes have been launched to control onchocerciasis, lymphatic filariasis, soil-transmitted ...
  • Role of metal ions on the activity of Mycobacterium tuberculosis pyrazinamidase 
    Sheen Cortavarria, Patricia; Ferrer, P.; Gilman, Robert Hugh; Christiansen, G.; Moreno-Román, P.; Gutiérrez, A.H.; Sotelo, J.; Evangelista, W.; Fuentes, P.; Rueda, D.; Flores, M.; Olivera, P.; Solis, J.; Pesaresi, A.; Lamba, D.; Zimic-Peralta, Mirko Juan (American Society of Tropical Medicine and Hygiene, 2012)
    Pyrazinamidase of Mycobacterium tuberculosis catalyzes the conversion of pyrazinamide to the active molecule pyrazinoic acid. Reduction of pyrazinamidase activity results in a level of pyrazinamide resistance. Previous ...
  • Serologic diagnosis of human Taenia solium cysticercosis by using recombinant and synthetic antigens in QuickELISA 
    Lee, Y.-M.; Handali, S.; Hancock, K.; Pattabhi, S.; Kovalenko, V.A.; Levin, A.; Rodriguez, S.; Lin, S.; Scheel, C.M.; Gonzalez Zariquiey, Armando Emiliano; Gilman, Robert Hugh; García Lescano, Héctor Hugo; Tsang, V.C.W. (American Society of Tropical Medicine and Hygiene, 2011)
    Diagnosis of Taenia solium cysticercosis is an important component in the control and elimination of cysticercosis and taeniasis. New detection assays using recombinant and synthetic antigens originating from the lentil ...
  • Serological diagnosis of lung cystic hydatid disease using the synthetic p176 peptide 
    Santivañez, S.J.; Arias, P.; Portocarrero, M.; Rodriguez, S.; Gonzalez Zariquiey, Armando Emiliano; Gilman, Robert Hugh; Gavidia, C.M.; García Lescano, Héctor Hugo (American Society for Microbiology, 2012)
    Cystic hydatid disease (CHD) is a worldwide zoonosis caused by the larval stage of the dog tapeworm Echinococcus granulosus. Diagnosis is based on imagenological tools (abdominal ultrasound, chest X-rays, or computed ...
  • Store-operated channels in the pulmonary circulation of high- and low-altitude neonatal lambs 
    Parrau, Daniela; Ebensperger, Germán; Herrera, Emilio A.; Moraga, Fernanda; Riquelme, Raquel A.; Ulloa, César E.; Rojas, Rodrigo T.; Silva, Pablo; Hernandez, Ismael; Ferrada, Javiera; Diaz, Marcela; Parer, Julian T.; Cabello, Gertrudis; Llanos, Aníbal J.; Reyes, Roberto V. (American Physiological Society, 2013)
    We determined whether store-operated channels (SOC) are involved in neonatal pulmonary artery function under conditions of acute and chronic hypoxia, using newborn sheep gestated and born either at high altitude (HA, 3,600 ...
  • Stunting Is Preceded by Intestinal Mucosal Damage and Microbiome Changes and Is Associated with Systemic Inflammation in a Cohort of Peruvian Infants. 
    Zambruni, Mara; Ochoa Woodell, Theresa Jean; Somasunderam, Anoma; Cabada, Miguel M.; Morales Fernández, María Luisa; Mitreva, Makedonka; Rosa, Bruce A.; Acosta, Gonzalo J.; Vigo, Natalia I.; Riveros Ramirez, Maribel Denise; Arango, Sara; Durand Vara, David Percy; Berends, Maitreyee N.; Melby, Peter; Utay, Netanya S. (American Society of Tropical Medicine and Hygiene, 2019)
    Stunting, defined as height-for-age Z score equal to or lower than -2, is associated with increased childhood mortality, cognitive impairment, and chronic diseases. The aim of the study was to investigate the relationship ...

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