Listar por autor "Appenzeller, Otto"

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  • Five hundred years of mercury exposure and adaptation. 
    Lombardi, Guido; Lanzirotti, Antonio; Qualls, Clifford; Socola, Francisco; Ali, Abdul-Mehdi; Appenzeller, Otto (Hindawi, 2012)
    Mercury is added to the biosphere by anthropogenic activities raising the question of whether changes in the human chromatin, induced by mercury, in a parental generation could allow adaptation of their descendants to ...
  • New Insights into the Genetic Basis of Monge's Disease and Adaptation to High-Altitude 
    Stobdan, Tsering; Akbari, Ali; Azad, Priti; Zhou, Dan; Poulsen, Orit; Appenzeller, Otto; Gonzales Rengifo, Gustavo Francisco; Telenti, Amalio; Wong, Emily H. M.; Saini, Shubham; Kirkness, Ewen F.; Venter, J. Craig; Bafna, Vineet; Haddad, Gabriel G. (Oxford University Press, 2017)
    Human high-altitude (HA) adaptation or mal-adaptation is explored to understand the physiology, pathophysiology, and molecular mechanisms that underlie long-term exposure to hypoxia. Here, we report the results of an ...
  • Whole-Genome sequencing uncovers the genetic basis of chronic mountain sickness in andean highlanders 
    Zhou, Dan; Udpa, Nitin; Ronen, Roy; Stobdan, Tsering; Liang, Junbin; Appenzeller, Otto; Zhao, Huiwen W.; Yin, Yi; Du, Yuanping; Guo, Lixia; Cao, Rui.; Wang, Yu; Jin, Xin; Huang, Chen; Jia, Wenlong; Cao, Dandan; Guo, Guangwu; Gamboa, Jorge L.; Villafuerte, Francisco C.; Callacondo, David; Xue, Jin; Liu, Siqi; Frazer, Kelly A.; Li, Yingrui; Bafna, Vineet; Haddad, Gabriel G. (Elsevier, 2013)
    The hypoxic conditions at high altitudes present a challenge for survival, causing pressure for adaptation. Interestingly, many highaltitude denizens (particularly in the Andes) are maladapted, with a condition known as ...

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