Listar por autor "Grandjean, Louis"

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  • Alternative cost-effective media to facilitate MODS culture for diagnostics of tuberculosis 
    Sheen Cortavarria, Patricia; Rodriguez, Joseline; Alcantara, Roberto; Vargas, Johnny; Grandjean, Louis; Moore, David Alexander James; Gilman, Robert Hugh; Zimic-Peralta, Mirko Juan (Elsevier, 2022)
    Most culture-based methods for tuberculosis diagnosis remain low-cost options for low- and mid-income countries. The MODS culture is a rapid and low-cost assay to diagnose tuberculosis and determine drug susceptibility. ...
  • The Association between Mycobacterium Tuberculosis Genotype and Drug Resistance in Peru 
    Grandjean, Louis; Iwamoto, Tomotada; Lithgow, Anna; Gilman, Robert Hugh; Arikawa, Kentaro; Nakanishi, Noriko; Martin, Laura; Castillo, Edith; Alarcon, Valentina; Coronel, Jorge; Solano, Walter; Aminian, Minoo; Guezala, Claudia; Rastogi, Nalin; Couvin, David; Sheen Cortavarria, Patricia; Zimic-Peralta, Mirko Juan; Moore, David Alexander James (Public Library of Science, 2015)
    BACKGROUND: The comparison of Mycobacterium tuberculosis bacterial genotypes with phenotypic, demographic, geospatial and clinical data improves our understanding of how strain lineage influences the development of ...
  • A case control study to identify community venues associated with genetically clustered Multidrug-resistant Tuberculosis disease in Lima, Peru 
    Bui, David P.; Oren, Eyal; Roe, Denise J.; Brown, Heidi E.; Harris, Robin B.; Knight, Gwenan M.; Gilman, Robert Hugh; Grandjean, Louis (Oxford University Press, 2018)
    Background: The majority of tuberculosis transmission occurs in community settings. The primary aim of this study was to assess the association between exposure to community venues and multidrug-resistant tuberculosis ...
  • A case report of transmission and disease caused by Mycobacterium caprae and Mycobacterium bovis in Lima, Peru. 
    Shrestha, Amber; Picoy, Janeth; Torres, Arturo; Moore, David Alexander James; Gilman, Robert Hugh; Coronel, Jorge; Grandjean, Louis (BioMed Central, 2021)
    BACKGROUND: The Tuberculosis (TB) burden in Peru is significant with respect to both disease morbidity and mortality. Furthermore the recent diversification of farming enterprise to include a wide range of animal species ...
  • Characterization of the carbohydrate components of Taenia solium oncosphere proteins and their role in the antigenicity 
    Arana, Yanina; Verastegui Pimentel, Manuela Renee; Tuero Ochoa, Iskra; Grandjean, Louis; García Lescano, Héctor Hugo; Gilman, Robert Hugh (Springer Verlag, 2013)
    This study examines the carbohydrate composition of Taenia solium whole oncosphere antigens (WOAs), in order to improve the understanding of the antigenicity of the T. solium. Better knowledge of oncosphere antigens is ...
  • Community transmission of multidrug-resistant tuberculosis is associated with activity space overlap in Lima, Peru 
    Bui, David P.; Chandran, Shruthi S.; Oren, Eyal; Brown, Heidi E.; Harris, Robin B.; Knight, Gwenan M.; Grandjean, Louis (BioMed Central, 2021)
    BACKGROUND: Transmission of multidrug-resistant tuberculosis (MDRTB) requires spatial proximity between infectious cases and susceptible persons. We assess activity space overlap among MDRTB cases and community controls ...
  • Convergent evolution and topologically disruptive polymorphisms among multidrug-resistant tuberculosis in Peru 
    Grandjean, Louis; Gilman, Robert Hugh; Iwamoto, Tomatada; Köser, Claudio U.; Coronel, Jorge; Zimic-Peralta, Mirko Juan; Török, M. Estee; Ayabina, Diepreye; Kendall, Michelle; Fraser, Christophe; Harris, Simon; Parkhill, Julian; Peacock, Sharon J.; Moore, David Alexander James; Colijn, Caroline (Public Library of Science, 2017)
    BACKGROUND: Multidrug-resistant tuberculosis poses a major threat to the success of tuberculosis control programs worldwide. Understanding how drug-resistant tuberculosis evolves can inform the development of new therapeutic ...
  • A crowd of BashTheBug volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates 
    Fowler, P.W.; Wright, C.; Spiers, H.; Zhu, T.; Baeten, E.M.L.; Hoosdally, S.W.; Cruz, A.L.G.; Roohi, A.; Kouchaki, S.; Walker, T.M.; Peto, T.E.A.; Miller, G.; Lintott, C.; Clifton, D.; Crook, D.W.; Walker, A.S.; Barilar, I.; Battaglia, S.; Borroni, E.; Brandao, A.P.; Brankin, A.; Cabibbe, A.M.; Carter, J.; Chetty, D.; Cirillo, D.M.; Claxton, P.; Clifton, D.A.; Cohen, T.; Coronel, Jorge; Dreyer, V.; Earle, S.G.; Escuyer, V.; Ferrazoli, L.; Gao, G.F.; Gardy, J.; Gharbia, S.; Ghisi, K.T.; Ghodousi, A.; Grandjean, Louis; Grazian, C.; Groenheit, R.; Guthrie, J.L.; He, W.; Hoffmann, H.; Hoosdally, S.J.; Martinhunt, M.; Iqbal, Z.; Ismail, N.A.; Jarrett, L.; Joseph, L.; Jou, R.; Kambli, P.; Khot, R.; Knaggs, J.; Koch, A.; Kohlerschmidt, D.; Lachapelle, A.S.; Lalvani, A.; Lapierre, S.G.; Laurenson, I.F.; Letcher, B.; Lin, W.-H.; Liu, C.; Liu, D.; Malone, K.M.; Mandal, A.; Mansjõ, M.; Matias, D.; Meintjes, G.; Mendes, F.D.F.; Merker, M.; Mihalic, M.; Millard, J.; Miotto, P.; Mistry, N.; Moore, David Alexander James; Musser, K.A.; Ngcamu, D.; Nhung, H.N.; Niemann, S.; Nilgiriwala, K.S.; Nimmo, C.; O’Donnell, M.; Okozi, N.; Oliveira, R.S.; Omar, S.V.; Paton, N.; Pinhata, J.M.W.; Plesnik, S.; Puyen, Z.M.; Rabodoarivelo, M.S.; Rakotosamimanana, N.; Rancoita, P.M.V.; Rathod, P.; Robinson, E.; Rodger, G.; Rodrigues, C.; Rodwell, T.C.; Santos-Lazaro, D.; Shah, S.; Kohl, T.A.; Smith, G.; Solano, Walter; Spitaleri, A.; Supply, P.; Steyn, A.J.C.; Surve, U.; Tahseen, S.; Thuong, N.T.T.; Thwaites, G.; Todt, K.; Trovato, A.; Utpatel, C.; Van Rie, A.; Vijay, S.; Walker, A.S.; Warren, R.; Werngren, J.; Wijkander, M.; Wilkinson, R.J.; Wilson, D.J.; Wintringer, P.; Xiao, Y.-X.; Yang, Y.; Yanlin, Z.; Yao, S.-Y.; Zhu, B.; The Zooniverse Volunteer Community; The CRyPTIC Consortium (eLife Sciences Publications, 2022)
    Tuberculosis is a respiratory disease that is treatable with antibiotics. An increasing prevalence of resistance means that to ensure a good treatment outcome it is desirable to test the susceptibility of each infection ...
  • Detecting Mutations in the Mycobacterium tuberculosis Pyrazinamidase Gene pncA to Improve Infection Control and Decrease Drug Resistance Rates in Human Immunodeficiency Virus Coinfection 
    Dudley, Matthew Z.; Sheen Cortavarria, Patricia; Gilman, Robert Hugh; Ticona, Eduardo; Friedland, Jon S.; Kirwan, Daniela E.; Caviedes, Luz; Rodriguez, Richard; Cabrera, Lilia Z.; Coronel, Jorge; Grandjean, Louis; Moore, David Alexander James; Evans, Carlton Anthony William; Huaroto, Luz; Chavez-Perez, Victor; Zimic-Peralta, Mirko Juan (American Society of Tropical Medicine and Hygiene, 2016)
    Hospital infection control measures are crucial to tuberculosis (TB) control strategies within settings caring for human immunodeficiency virus (HIV)–positive patients, as these patients are at heightened risk of developing ...
  • Determination of potentially novel compensatory mutations in rpoC associated with rifampin resistance and rpoB mutations in Mycobacterium tuberculosis Clinical isolates from Peru 
    Vargas Ruiz, Ana Paula; Rios, A.; Grandjean, Louis; Kirwan, D.; Gilman, Robert Hugh; Sheen Cortavarria, Patricia; Zimic-Peralta, Mirko Juan (Medknow Publications, 2020)
    Background: Rifampicin (RIF) resistance in Mycobacterium tuberculosis is frequently caused by mutations in the rpoB gene. These mutations are associated with a fitness cost, which can be overcome by compensatory mutations ...
  • dfrA thyA Double Deletion in para-Aminosalicylic Acid-Resistant Mycobacterium tuberculosis Beijing Strains 
    Moradigaravand, Danesh; Grandjean, Louis; Martinez, Elena; Li, Hao; Zheng, Jun; Coronel, Jorge; Moore, David Alexander James; Torok, M. Estee; Sintchenko, Vitali; Huang, Hairong; Javid, Babak; Parkhill, Julian; Peacock, Sharon-J.; Koser, Claudio-U. (American Society for Microbiology, 2016)
    Para-Aminosalicylic acid (PAS) is a group 4 antituberculosis agent. It targets folate metabolism as shown in Fig. S1 in the supplemental material, which also summarizes the known mechanisms of resistance to this prodrug. ...
  • Epidemiological cutoff values for a 96-well broth microdilution plate for high-throughput research antibiotic susceptibility testing of M. tuberculosis 
    Fowler, P.W.; Barilar, I.; Battaglia, S.; Borroni, E.; Brandao, A.P.; Brankin, A.; Cabibbe, A.M.; Carter, J.; Cirillo, D.M.; Claxton, P.; Clifton, D.A.; Cohen, T.; Coronel, Jorge; Crook, D.W.; Dreyer, V.; Earle, S.G.; Escuyer, V.; Ferrazoli, L.; Gao, G.F.; Gardy, J.; Gharbia, S.; Ghisi, K.T.; Ghodousi, A.; Cruz, A.L.G.; Grandjean, Louis; Grazian, C.; Groenheit, R.; Guthrie, J.L.; He, W.; Hoffmann, H.; Hoosdally, S.J.; Hunt, M.; Iqbal, Z.; Ismail, N.A.; Jarrett, L.; Joseph, L.; Jou, R.; Kambli, P.; Khot, R.; Knaggs, J.; Koch, A.; Kohlerschmidt, D.; Kouchaki, S.; Lachapelle, A.S.; Lalvani, A.; Lapierre, S.G.; Laurenson, I.F.; Letcher, B.; Lin, W.-H.; Liu, C.; Liu, D.; Malone, K.M.; Mandal, A.; Mansjö, M.; Matias, D.; Meintjes, G.; de Freitas Mendes, F.; Merker, M.; Mihalic, M.; Millard, J.; Miotto, P.; Mistry, N.; Moore, David Alexander James; Musser, K.A.; Ngcamu, D.; Nhung, H.N.; Niemann, S.; Nilgiriwala, K.S.; Nimmo, C.; Okozi, N.; Oliveira, R.S.; Omar, S.V.; Paton, N.; Peto, T.E.A.; Pinhata, J.M.W.; Plesnik, S.; Puyen, Z.M.; Rabodoarivelo, M.S.; Rakotosamimanana, N.; Rancoita, P.M.V.; Rathod, P.; Robinson, E.; Rodger, G.; Rodrigues, C.; Rodwell, T.C.; Roohi, A.; Santos-Lazaro, D.; Shah, S.; Kohl, T.A.; Smith, G.; Solano, Walter; Spitaleri, A.; Supply, P.; Surve, U.; Tahseen, S.; Thuong, N.T.T.; Thwaites, G.; Todt, K.; Trovato, A.; Utpatel, C.; Van Rie, A.; Vijay, S.; Walker, T.M.; Walker, A.S.; Warren, R.; Werngren, J.; Wijkander, M.; Wilkinson, R.J.; Wilson, D.J.; Wintringer, P.; Xiao, Y.-X.; Yang, Y.; Yanlin, Z.; Yao, S.-Y.; Zhu, B. (European Respiratory Society, 2022)
    Drug susceptibility testing of M. tuberculosis is rooted in a binary susceptible/resistant paradigm. Whilst there are considerable advantages in measuring the minimum inhibitory concentrations (MICs) of a panel of drugs ...
  • Evaluation of three alternatives cost-effective culture media for Mycobacterium tuberculosis detection and drug susceptibility determination using the microscopic observation drug susceptibility (MODS) assay 
    Rodriguez, Jhojailith; Alcántara, R.; Rodríguez, Joseline; Vargas, J.; Roncal, Elisa; Antiparra, Ricardo; Gilman, Robert Hugh; Grandjean, Louis; Moore, David Alexander James; Zimic-Peralta, Mirko Juan; Sheen Cortavarria, Patricia (Elsevier, 2022)
    Tuberculosis phenotypic detection assays are commonly used in low-resource countries. Therefore, reliable detection methods are crucial for early diagnosis and treatment. The microscopic observation drug susceptibility ...
  • A field evaluation of the Hardy TB MODS kit™ for the rapid phenotypic diagnosis of tuberculosis and multi-drug resistant tuberculosis 
    Martin, Laura; Coronel, Jorge; Faulx, Dunia; Valdez, Melissa; Metzler, Mutsumi; Crudder, Chris; Castillo, Edith; Caviedes, Luz; Grandjean, Louis; Rodriguez, Mitzi; Friedland, Jon S.; Gilman, Robert Hugh; Moore, David Alexander James (Public Library of Science, 2014)
    BACKGROUND: Even though the WHO-endorsed, non-commercial MODS assay offers rapid, reliable TB liquid culture and phenotypic drug susceptibility testing (DST) at lower cost than any other diagnostic, uptake has been patchy. ...
  • Genetic Diversity and Transmission Characteristics of Beijing Family Strains of Mycobacterium tuberculosis in Peru 
    Iwamoto, T.; Grandjean, Louis; Arikawa, K.; Nakanishi, N.; Caviedes, L.; Coronel, J.; Sheen Cortavarria, Patricia; Wada, T.; Taype, C.A.; Shaw, M.-A.; Moore, David Alexander James; Gilman, Robert Hugh (Public Library of Science, 2012)
    Beijing family strains of Mycobacterium tuberculosis have attracted worldwide attention because of their wide geographical distribution and global emergence. Peru, which has a historical relationship with East Asia, is ...
  • Genetic Diversity of Mycobacterium tuberculosis in Peru and Exploration of Phylogenetic Associations with Drug Resistance 
    Sheen Cortavarria, Patricia; Couvin, David; Grandjean, Louis; Zimic-Peralta, Mirko Juan; Dominguez, Maria; Luna, Giannina; Gilman, Robert Hugh; Rastogi, Nalin; Moore, David Alexander James (Public Library of Science, 2013)
    Background: There is limited available data on the strain diversity of M tuberculosis in Peru, though there may be interesting lessons to learn from a setting where multidrug resistant TB has emerged as a major problem ...
  • Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis 
    Coll, Francesc; Phelan, Jody; Hill-Cawthorne, Grant A.; Nair, Mridul B.; Mallard, Kim; Ali, Shahjahan; Abdallah, Abdallah M.; Alghamdi, Saad; Alsomali, Mona; Ahmed, Abdallah O.; Portelli, Stephanie; Oppong, Yaa; Alves, Adriana; Bessa, Theolis Barbosa; Campino, Susana; Caws, Maxine; Chatterjee, Anirvan; Crampin, Amelia C.; Dheda, Keertan; Furnham, Nicholas; Glynn, Judith R.; Grandjean, Louis; Minh Ha, Dang; Hasan, Rumina; Hasan, Zahra; Hibberd, Martin L.; Joloba, Moses; Jones-López, Edward C.; Matsumoto, Tomoshige; Miranda, Anabela; Moore, David Alexander James; Mocillo, Nora; Panaiotov, Stefan; Parkhill, Julian; Penha, Carlos; Perdigão, João; Portugal, Isabel; Rchiad, Zineb; Robledo, Jaime; Sheen Cortavarria, Patricia; Shesha, Nashwa Talaat; Sirgel, Frik A.; Sola, Christophe; Oliveira Sousa, Erivelton; Streicher, Elizabeth M.; Helden, Paul Van; Viveiros, Miguel; Warren, Robert M.; McNerney, Ruth; Pain, Arnab; Clark, Taane G. (Springer Nature, 2018)
    To characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis clinical isolates from more than 30 countries. A ...
  • Genomic signatures of pre-resistance in Mycobacterium tuberculosis. 
    Torres Ortiz, Arturo; Coronel, Jorge; Vidal, Julia Rios; Bonilla, Cesar; Moore, David Alexander James; Gilman, Robert Hugh; Balloux, Francois; Kon, Onn Min; Didelot, Xavier; Grandjean, Louis (Springer Nature, 2021)
    Recent advances in bacterial whole-genome sequencing have resulted in a comprehensive catalog of antibiotic resistance genomic signatures in Mycobacterium tuberculosis. With a view to pre-empt the emergence of resistance, ...
  • Investigating spillover of multidrug-resistant tuberculosis from a prison: a spatial and molecular epidemiological analysis 
    Warren, Joshua L.; Grandjean, Louis; Moore, David Alexander James; Lithgow, Anna; Coronel, Jorge; Sheen Cortavarria, Patricia; Zelner, Jonathan L.; Andrews, Jason R.; Cohen, Ted (BioMed Central, 2018)
    BACKGROUND: Congregate settings may serve as institutional amplifiers of tuberculosis (TB) and multidrug-resistant tuberculosis (MDR-TB). We analyze spatial, epidemiological, and pathogen genetic data prospectively collected ...
  • Isoniazid Preventive Therapy in Contacts of Multidrug-resistant Tuberculosis. 
    Huang, Chuan-Chin; Becerra, Mercedes C.; Calderon, Roger; Contreras, Carmen; Galea, Jerome; Grandjean, Louis; Lecca, Leonid; Yataco, Rosa; Zhang, Zibiao; Murray, Megan (American Thoracic Society, 2020)
    RATIONALE: The World Health Organization recommends the use of isoniazid alone or in combination with rifapentine to treat latent tuberculosis infection. The recent rise of drug-resistant tuberculosis has complicated the ...

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