Listar por tema "Andean"

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  • Clotting factor genes are associated with preeclampsia in high-altitude pregnant women in the Peruvian Andes 
    Nieves-Colón, M.A.; Badillo Rivera, K.M.; Sandoval, K.; Villanueva Dávalos, V.; Enriquez Lencinas, L.E.; Mendoza-Revilla, Javier; Adhikari, K.; González-Buenfil, R.; Chen, J.W.; Zhang, E.T.; Sockell, A.; Ortiz-Tello, P.; Hurtado, Gloria Malena; Condori Salas, Ramiro; Cebrecos, Ricardo; Manzaneda Choque, J.C.; Manzaneda Choque, F.P.; Yábar Pilco, G.P.; Rawls, E.; Eng, C.; Huntsman, S.; Burchard, E.; Ruiz-Linares, A.; González-José, R.; Bedoya, G.; Rothhammer, F.; Bortolini, M.C.; Poletti, Giovanni; Gallo López-Aliaga, Carla Maria; Bustamante, C.D.; Baker, J.C.; Gignoux, C.R.; Wojcik, G.L.; Moreno-Estrada, A. (Elsevier, 2022)
    Preeclampsia is a multi-organ complication of pregnancy characterized by sudden hypertension and proteinuria that is among the leading causes of preterm delivery and maternal morbidity and mortality worldwide. The heterogeneity ...
  • Cross-Sectional Comparison of Sleep-Disordered Breathing in Native Peruvian Highlanders and Lowlanders 
    Pham, Luu V.; Meinzen, Christopher; Arias, Rafael S.; Schwartz, Noah G.; Rattner, Adi; Miele, Catherine H.; Smith, Philip L.; Schneider, Hartmut; Miranda, J. Jaime; Gilman, Robert Hugh; Polotsky, Vsevolod Y.; Checkley, William; Schwartz, Alan R. (Mary Ann Liebert, 2017)
    BACKGROUND: Altitude can accentuate sleep disordered breathing (SDB), which has been linked to cardiovascular and metabolic diseases. SDB in highlanders has not been characterized in large controlled studies. The purpose ...
  • Genetic variants at the EGLN1 locus associated with high-altitude adaptation in Tibetans are absent or found at low frequency in highland Andeans 
    Heinrich, E.C.; Wu, L.; Lawrence, E.S.; Cole, A.M.; Anza-Ramirez, C.; Villafuerte, Francisco C.; Simonson, T.S. (Wiley, 2019)
    EGLN1 encodes the hypoxia-inducible factor (HIF) pathway prolyl hydroxylase 2 (PHD2) that serves as an oxygen-sensitive regulator of HIF activity. The EGLN1 locus exhibits a signature of positive selection in Tibetan and ...
  • Global REACH: assessment of brady-arrhythmias in andeans and lowlanders during apnea at 4330 m 
    Busch, Stephen A.; van Diepen, Sean; Steele, Andrew R.; Meah, Victoria L.; Simpson, Lydia L.; Figueroa-Mujíca, Rómulo J.; Vizcardo-Galindo, Gustavo; Villafuerte, Francisco C.; Tymko, Michael M.; Ainslie, Philip N.; Moore, Jonathan P.; Stembridge, Mike; Steinback, Craig D. (Frontiers Media, 2019)
    Background: Ascent to altitude increases the prevalence of arrhythmogenesis in low-altitude dwelling populations (Lowlanders). High altitude populations (i.e., Nepalese Sherpa) may have arrhythmias resistant adaptations ...
  • Global Research Expedition on Altitude-related Chronic Health 2018 Iron Infusion at High Altitude Reduces Hypoxic Pulmonary Vasoconstriction Equally in Both Lowlanders and Healthy Andean Highlanders. 
    Patrician, Alexander; Dawkins, Tony; Coombs, Geoff B.; Stacey, Benjamin; Gasho, Christopher; Gibbons, Travis; Howe, Connor A.; Tremblay, Joshua C.; Stone, Rachel; Tymko, Kaitlyn; Tymko, Courtney; Akins, John D.; Hoiland, Ryan L.; Vizcardo-Galindo, Gustavo A.; Figueroa-Mujíca, Rómulo; Villafuerte, Francisco C.; Bailey, Damian M.; Stembridge, Michael; Anholm, James D.; Tymko, Michael M.; Ainslie, Philip N. (Elsevier, 2021)
    BACKGROUND: Increasing iron bioavailability attenuates hypoxic pulmonary vasoconstriction in both lowlanders and Sherpas at high altitude. In contrast, the pulmonary vasculature of Andeans with chronic mountain sickness ...
  • Increased hypoxic proliferative response and gene expression in erythroid progenitor cells of Andean highlanders with Chronic Mountain Sickness. 
    Bermudez, Daniela; Azad, Priti; Figueroa-Mujica, Romulo; Vizcardo-Galindo, Gustavo; Corante, Noemi; Guerra-Giraldez, Cristina; Haddad, Gabriel G.; Villafuerte, Francisco C. (American Physiological Society, 2019)
    Excessive erythrocytosis (EE) is the main sign of Chronic Mountain Sickness (CMS), a maladaptive clinical syndrome prevalent in Andean and other high-altitude populations worldwide. The pathophysiological mechanism of EE ...

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