Listar por tema "Antitubercular Agents/pharmacology"

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dfrA thyA Double Deletion in para-Aminosalicylic Acid-Resistant Mycobacterium tuberculosis Beijing Strains

Moradigaravand, Danesh; Grandjean, Louis; Martinez, Elena; Li, Hao; Zheng, Jun; Coronel, Jorge; Moore, David Alexander James; Torok, M. Estee; Sintchenko, Vitali; Huang, Hairong; Javid, Babak; Parkhill, Julian; Peacock, Sharon-J.; Koser, Claudio-U. (American Society for Microbiology, 2016)

Para-Aminosalicylic acid (PAS) is a group 4 antituberculosis agent. It targets folate metabolism as shown in Fig. S1 in the supplemental material, which also summarizes the known mechanisms of resistance to this prodrug. ...
Evaluation of Microscopic Observation Drug Susceptibility (MODS) and the string test for rapid diagnosis of pulmonary tuberculosis in HIV/AIDS patients in Bolivia

Lora, Meredith H.; Reimer-McAtee, Melissa J.; Gilman, Robert Hugh; Lozano, Daniel; Saravia, Ruth; Pajuelo Travezaño, Monica Jhenny; Bern, Caryn; Castro, Rosario; Espinoza, Magaly; Vallejo, Maya; Solano, Marco; Challapa, Roxana; Torrico, Faustino (BioMed Central, 2015)

Background: Tuberculosis (TB) is the most common opportunistic infection and the leading cause of death in HIV-positive people worldwide. Diagnosing TB is difficult, and is more challenging in resource-scarce settings where ...
A field evaluation of the Hardy TB MODS kit™ for the rapid phenotypic diagnosis of tuberculosis and multi-drug resistant tuberculosis

Martin, Laura; Coronel, Jorge; Faulx, Dunia; Valdez, Melissa; Metzler, Mutsumi; Crudder, Chris; Castillo, Edith; Caviedes, Luz; Grandjean, Louis; Rodriguez, Mitzi; Friedland, Jon S.; Gilman, Robert Hugh; Moore, David Alexander James (Public Library of Science, 2014)

BACKGROUND: Even though the WHO-endorsed, non-commercial MODS assay offers rapid, reliable TB liquid culture and phenotypic drug susceptibility testing (DST) at lower cost than any other diagnostic, uptake has been patchy. ...
Minimum inhibitory concentration distributions for first- and second-line antimicrobials against Mycobacterium tuberculosis

Burke, Rachael M.; Coronel, Jorge; Moore, David Alexander James (Microbiology Society, 2017)

We report the range of minimum inhibitory concentrations for six antimicrobial drugs in 228 clinical Mycobacterium tuberculosis (MTB) isolates from three distinct groups of patients (unselected patients, patients at high ...
A multiple genome analysis of Mycobacterium tuberculosis reveals specific novel genes and mutations associated with pyrazinamide resistance

Sheen Cortavarria, Patricia; Requena, David; Gushiken, Eduardo; Gilman, Robert Hugh; Antiparra, Ricardo; Lucero, Bryan; Lizárraga, Pilar; Cieza, Basilio; Roncal, Elisa; Grandjean, Louis; Pain, Arnab; McNerney, Ruth; Clark, Taane G.; Moore, David Alexander James; Zimic-Peralta, Mirko Juan (BioMed Central, 2017)

BACKGROUND: Tuberculosis (TB) is a major global health problem and drug resistance compromises the efforts to control this disease. Pyrazinamide (PZA) is an important drug used in both first and second line treatment ...
Rapid Detection of Mycobacterium tuberculosis Strains Resistant to Isoniazid and/or Rifampicin: Standardization of Multiplex Polymerase Chain Reaction Analysis

Collantes, Jimena; Solari, Francesca-Barletta; Rigouts, Leen (American Society of Tropical Medicine and Hygiene, 2016)

Drug susceptibility testing using molecular techniques can enhance the identification of drug-resistant Mycobacterium tuberculosis Two multiplex real-time polymerase chain reaction (qPCR) assays were developed to detect ...

Listar por tema "Antitubercular Agents/pharmacology"

Listar por tema "Antitubercular Agents/pharmacology"

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