Universidad Peruana Cayetano Heredia

Listar por tema "Antitubercular Agents/therapeutic use"

Listar por tema "Antitubercular Agents/therapeutic use"

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  • Clinical evaluation of tuberculosis viability microscopy for assessing treatment response 
    Datta, Sumona; Sherman, Jonathan M.; Bravard, Marjory A.; Valencia, Teresa; Gilman, Robert Hugh; Evans, Carlton Anthony William (Oxford University Press, 2015)
    BACKGROUND: It is difficult to determine whether early tuberculosis treatment is effective in reducing the infectiousness of patients' sputum, because culture takes weeks and conventional acid-fast sputum microscopy and ...
  • Drug-resistance mechanisms and tuberculosis drugs 
    Koser, Claudio U.; Javid, Babak; Liddell, Kathleen; Ellington, Matthew J.; Feuerriegel, Silke; Niemann, Stefan; Brown, Nicholas M.; Burman, William J.; Abubakar, Ibrahim; Ismail, Nazir A.; Moore, David Alexander James; Peacock, Sharon J.; Torok, M. Estee (Elsevier, 2015)
    Bedaquiline and delamanid, novel classes of anti-tuberculosis drugs, have been recently approved for the treatment of multidrug-resistant tuberculosis. Antimicrobial resistance invariably follows the introduction of new ...
  • Dynamics of Cough Frequency in Adults Undergoing Treatment for Pulmonary Tuberculosis 
    Proano, Alvaro; Bravard, Marjory A.; Lopez, Jose W.; Lee, Gwenyth O.; Bui, David; Datta, Sumona; Comina, German; Zimic-Peralta, Mirko Juan; Coronel, Jorge; Caviedes, Luz; Cabrera, Jose L.; Salas, Antonio; Ticona, Eduardo; Vu, Nancy M.; Kirwan, Daniela E.; Loader, Maria-Cristina I.; Friedland, Jon S.; Moore, David Alexander James; Evans, Carlton Anthony William; Tracey, Brian H.; Gilman, Robert Hugh (Oxford University Press, 2017)
    Background: Cough is the major determinant of tuberculosis transmission. Despite this, there is a paucity of information regarding characteristics of cough frequency throughout the day and in response to tuberculosis ...
  • Evaluation of a lens-free imager to facilitate tuberculosis diagnostics in MODS 
    Solis, Leonardo; Coronel, Jorge; Rueda, Daniel; Gilman, Robert Hugh; Sheen Cortavarria, Patricia; Zimic-Peralta, Mirko Juan (Elsevier, 2015)
    Tuberculosis (TB) control efforts are hampered by a mismatch in diagnostic technology. Lack of adequate early diagnostics and Multi-drug resistant (MDR) detection is a critical problem in control efforts. Alternate and ...
  • Impact of Infection Control Measures to Control an Outbreak of Multidrug-Resistant Tuberculosis in a Human Immunodeficiency Virus Ward, Peru 
    Ticona, Eduardo; Huaroto, Luz; Kirwan, Daniela E.; Chumpitaz, Milagros; Munayco, Cesar V.; Maguina, Monica; Tovar, Marco A.; Evans, Carlton Anthony William; Escombe, Roderick; Gilman, Robert Hugh (American Society of Tropical Medicine and Hygiene, 2016)
    Multidrug-resistant tuberculosis (MDRTB) rates in a human immunodeficiency virus (HIV) care facility increased by the year 2000-56% of TB cases, eight times the national MDRTB rate. We reported the effect of tuberculosis ...
  • Multidrug resistant tuberculosis 
    Millard, James; Ugarte Gil, Cesar Augusto; Moore, David Alexander James (BMJ Publishing Group, 2015)
    Tuberculosis remains a major cause of morbidity and mortality globally, with an estimated nine million people developing the disease and 1.5 million deaths in 2013; equating to 4100 deaths a day.1 Nevertheless, considerable ...
  • Patient Characteristics Associated with Tuberculosis Treatment Default: A Cohort Study in a High-Incidence Area of Lima, Peru 
    Lackey, Brian; Seas Ramos, Carlos Rafael; Van der Stuyft, Patrick; Otero Vegas, Larissa (Public Library of Science, 2015)
    BACKGROUND: Although tuberculosis (TB) is usually curable with antibiotics, poor adherence to medication can lead to increased transmission, drug resistance, and death. Prior research has shown several factors to be ...
  • Perceptions and acceptability of short message services technology to improve treatment adherence amongst tuberculosis patients in Peru: a Focus Group Study 
    Albino, Sandra; Tabb, Karen M.; Requena, David; Egoavil, Miguel; Pineros-Leano, Maria F.; Zunt, Joseph R.; Garcia Funegra, Patricia Jannet (Public Library of Science, 2014)
    BACKGROUND: Tuberculosis (TB) is global health concern and a leading infectious cause of mortality. Reversing TB incidence and disease-related mortality is a major global health priority. Infectious disease mortality is ...
  • Prevalence, Risk Factors, and Treatment Outcomes of Isoniazid- and Rifampicin-Mono-Resistant Pulmonary Tuberculosis in Lima, Peru 
    Villegas, Leonela; Otero Vegas, Larissa; Sterling, Timothy-R.; Huaman, Moises-A.; Van-der-Stuyft, Patrick; Gotuzzo Herencia, José Eduardo; Seas Ramos, Carlos Rafael (Public Library of Science, 2016)
    BACKGROUND: Isoniazid and rifampicin are the two most efficacious first-line agents for tuberculosis (TB) treatment. We assessed the prevalence of isoniazid and rifampicin mono-resistance, associated risk factors, and the ...
  • Protocol for studying cough frequency in people with pulmonary tuberculosis 
    Proaño, Alvaro; Bravard, Marjory A.; Tracey, Brian H.; Lopez, Jose W.; Comina, German; Zimic-Peralta, Mirko Juan; Coronel, Jorge; Lee, Gwenyth O'Neil; Caviedes, Luz; Cabrera, Jose Luis; Salas, Antonio; Ticona, Eduardo; Kirwan, Daniela E.; Friedland, Jon S.; Evans, Carlton Anthony William; Moore, David Alexander James; Gilman, Robert Hugh (BMJ Publishing Group, 2016)
    INTRODUCTION: Cough is a key symptom of tuberculosis (TB) as well as the main cause of transmission. However, a recent literature review found that cough frequency (number of coughs per hour) in patients with TB has only ...
  • Second-line drug susceptibility breakpoints for Mycobacterium tuberculosis using the MODS assay 
    Trollip, A. P.; Moore, David Alexander James; Coronel, J.; Caviedes, L.; Klages, S.; Victor, T.; Romancenco, E.; Crudu, V.; Ajbani, K.; Vineet, V. P.; Rodrigues, C.; Jackson, R. L.; Eisenach, K.; Garfein, R. S.; Rodwell, T. C.; Desmond, E.; Groessl, E. J.; Ganiats, T. G.; Catanzaro, A. (International Union Against Tuberculosis and Lung Disease, 2014)
    OBJECTIVE: To establish breakpoint concentrations for the fluoroquinolones (moxifloxacin [MFX] and ofloxacin [OFX]) and injectable second-line drugs (amikacin [AMK], kanamycin [KM] and capreomycin [CPM]) using the microscopic ...
  • Sustained Benefit of Community-based Tuberculosis Interventions after 30 Years 
    Accinelli Tanaka, Roberto Alfonso; Romero, Lelia R.; Garcia, Rosa F.; Sanchez, Ricardo (American Thoracic Society, 2015)
    In 1985, the overall rate of tuberculosis (TB) in Peru was 145 per 100,000 people, with higher rates seen in isolated regions in the greater Lima area. Between 1985 and 1990, the Peruvian economy shrank 10.1%; the rate of ...
  • Time to initiation of multidrug-resistant tuberculosis treatment and its relation with outcome in a high incidence district in Lima, Peru 
    Otero Vegas, Larissa; De Orbegoso, A.; Navarro, A. F.; Ríos, J.; Párraga, T.; Gotuzzo Herencia, José Eduardo; Seas Ramos, Carlos Rafael; Van der Stuyft, P. (Wiley, 2015)
    OBJECTIVE: To determine the time from diagnosis to start of multidrug resistant tuberculosis (MDR TB) treatment in Lima, Peru. METHODS: We studied new smear-positive TB adults that were started on MDR TB treatment or that ...
  • Towards cash transfer interventions for tuberculosis prevention, care and control: key operational challenges and research priorities 
    Boccia, Delia; Pedrazzoli, Debora; Wingfield, Tom; Jaramillo, Ernesto; Lonnroth, Knut; Lewis, James; Hargreaves, James; Evans, Carlton Anthony William (BioMed Central, 2016)
    BACKGROUND: Cash transfer interventions are forms of social protection based on the provision of cash to vulnerable households with the aim of reduce risk, vulnerability, chronic poverty and improve human capital. Such ...
  • Transmission of Multidrug-Resistant and Drug-Susceptible Tuberculosis within Households: A Prospective Cohort Study 
    Grandjean, Louis; Gilman, Robert Hugh; Martin, Laura; Soto, Esther; Castro, Beatriz; Lopez, Sonia; Coronel, Jorge; Castillo, Edith; Alarcon, Valentina; Lopez, Virginia; San Miguel, Angela; Quispe, Neyda; Asencios, Luis; Dye, Christopher; Moore, David Alexander James (Public Library of Science, 2015)
    BACKGROUND: The "fitness" of an infectious pathogen is defined as the ability of the pathogen to survive, reproduce, be transmitted, and cause disease. The fitness of multidrug-resistant tuberculosis (MDRTB) relative to ...
  • Weight variation over time and its relevance among multidrug-resistant tuberculosis patients 
    Chung-Delgado, Kocfa; Revilla-Montag, Alejandro; Guillen-Bravo, Sonia; Bernabé Ortiz, Antonio (Elsevier, 2014)
    OBJECTIVES: We aimed to assess the variation in patient body weight over time according to the treatment outcome among multidrug-resistant tuberculosis (MDR-TB) cases. METHODS: This was a retrospective cohort study. The ...

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