Browsing by Subject "Delamanid"

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Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients

Reichmuth, M.L.; Hömke, R.; Zürcher, K.; Sander, P.; Avihingsanon, A.; Collantes, J.; Loiseau, C.; Borrell, S.; Reinhard, M.; Wilkinson, R.J.; Yotebieng, M.; Fenner, L.; Böttger, E.C.; Gagneux, S.; Egger, M.; Keller, P.M.; International epidemiology Databases to Evaluate AIDS (IeDEA) (American Society for Microbiology, 2020)

Mutations in the genes of the F420 signaling pathway of Mycobacterium tuberculosis complex, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, can lead to delamanid resistance. We searched for such mutations among 129 M. ...

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