Listar por tema "enzyme activity"

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  • Adaptation to milking agropastoralism in chilean goat herders and nutritional benefit of lactase persistence 
    Montalva, Nicolás; Adhikari, Kaustubh; Liebert, Anke; Mendoza-Revilla, Javier; Flores, Sergio V.; Mace, Ruth; Swallow, Dallas M. (Wiley, 2018)
    The genetic trait of lactase persistence (LP) evolved as an adaptation to milking pastoralism in the Old World and is a well-known example of positive natural selection in humans. However, the specific mechanisms conferring ...
  • Ascorbate variations and dehydroascorbate reductase activity in Trypanosoma cruzi epimastigotes and trypomastigotes 
    Clark, Daniel; Albrecht, Miguel; Arévalo Zelada, Jorge Luis (Elsevier, 1994)
    Trypanosoma cruzi, the causative agent of Chagas' disease, has been considered for many years as an organism with limited capability to metabolize...
  • The C57Bl/6 mouse serves as a suitable model of human skeletal muscle mitochondrial function 
    Jacobs, Robert A.; Díaz, Víctor; Meinild, Anne-Kristine; Gassmann, Max; Lundby, Carsten (Wiley, 2013)
    It is debatable whether differences in mitochondrial function exist across skeletal muscle types and whether mouse skeletal muscle mitochondrial function can serve as a valid model for human skeletal muscle mitochondrial function…
  • Characterization of a novel cathepsin L-like protease from Taenia solium metacestodes for the immunodiagnosis of porcine cysticercosis 
    Leon-Janampa, Nancy; Liendo, Ruddy; Gilman, Robert Hugh; Padilla, Carlos; García Lescano, Héctor Hugo; Gonzales, Armando; Sheen Cortavarria, Patricia; Pajuelo Travezaño, Monica Jhenny; Zimic-Peralta, Mirko Juan; Cysticercosis Working Group in Peru (Elsevier, 2019)
    Porcine cysticercosis is an endemic parasitic disease caused by infection with Taenia solium that is found predominantly in developing countries. In order to aid in the development of simple diagnostic approaches, ...
  • Increased reliance on carbohydrates for aerobic exercise in highland andean leaf-eared mice, but not in highland lima leaf-eared mice 
    Schippers, M.-P.; Ramirez, O.; Arana, M.; McClelland, G.B. (MDPI, 2021)
    Exercise is an important performance trait in mammals and variation in aerobic capacity and/or substrate allocation during submaximal exercise may be important for survival at high altitude. Comparisons between lowland and ...
  • Mechanisms of liver fibrosis associated with experimental fasciola hepatica infection: Roles of Fas2 proteinase and hepatic stellate cell activation 
    Marcos, L.A.; Terashima, A.; Yi, P.; Andrade, R.; Cubero, F.J.; Albanis, E.; Gotuzzo Herencia, José Eduardo; Espinoza, J.R.; Friedman, S.L. (American Society of Parasitologists, 2011)
    We have evaluated the possible mechanisms of liver fibrosis caused by Fasciola hepatica in an animal model and in culture using immortalized human stellate cells. Liver biopsies of F. hepatica-infected rats were performed ...
  • Oil emulsion from Plukenetia huayllabambana (Sacha inchi) modifies nitric oxide and leptin in the liver and antioxidant and inflammation markers in the adipose tissue in obese rats 
    Ambulay, J.P.; Rojas, P.A.; Timoteo, O.S.; Barreto, T.V.; Vila, Z.N.; de los Santos, M.B.; Eguiluz, M.; Colarossi, A. (Food Science Publisher, 2021)
    Background: Obesity is characterized by excessive accumulation of adipose tissue and is associated with higher risk of metabolic diseases and other comorbidities. Efficacious strategies including a diet high in “functional ...
  • Role of metal ions on the activity of Mycobacterium tuberculosis pyrazinamidase 
    Sheen Cortavarria, Patricia; Ferrer, P.; Gilman, Robert Hugh; Christiansen, G.; Moreno-Román, P.; Gutiérrez, A.H.; Sotelo, J.; Evangelista, W.; Fuentes, P.; Rueda, D.; Flores, M.; Olivera, P.; Solis, J.; Pesaresi, A.; Lamba, D.; Zimic-Peralta, Mirko Juan (American Society of Tropical Medicine and Hygiene, 2012)
    Pyrazinamidase of Mycobacterium tuberculosis catalyzes the conversion of pyrazinamide to the active molecule pyrazinoic acid. Reduction of pyrazinamidase activity results in a level of pyrazinamide resistance. Previous ...
  • Series "matrix metalloproteinases in lung health and disease": Matrix metalloproteinases in tuberculosis 
    Elkington, P.T.; Ugarte Gil, Cesar Augusto; Friedland, J.S. (European Respiratory Society, 2011)
    Tuberculosis (TB) remains a global health pandemic. Infection is spread by the aerosol route and Mycobacterium tuberculosis must drive lung destruction to be transmitted to new hosts. Such inflammatory tissue damage is ...
  • Single-dose tafenoquine to prevent relapse of plasmodium vivax malaria 
    Lacerda, M.V.G.; Llanos Cuentas, Elmer Alejandro; Krudsood, S.; Lon, C.; Saunders, D.L.; Mohammed, R.; Yilma, D.; Pereira, D.B.; Espino, F.E.J.; Mia, R.Z.; Chuquiyauri, R.; Val, F.; Casapía, M.; Monteiro, W.M.; Brito, M.A.M.; Costa, M.R.F.; Buathong, N.; Noedl, H.; Diro, E.; Getie, S.; Wubie, K.M.; Abdissa, A.; Zeynudin, A.; Abebe, C.; Tada, M.S.; Brand, F.; Beck, H.-P.; Angus, B.; Duparc, S.; Kleim, J.-P.; Kellam, L.M.; Rousell, V.M.; Jones, S.W.; Hardaker, E.; Mohamed, K.; Clover, D.D.; Fletcher, K.; Breton, J.J.; Ugwuegbulam, C.O.; Green, J.A.; Koh, G.C.K.W. (Massachusetts Medical Society, 2019)
    BACKGROUND: Treatment of Plasmodium vivax malaria requires the clearing of asexual parasites, but relapse can be prevented only if dormant hypnozoites are cleared from the liver (a treatment termed "radical cure"). Tafenoquine ...
  • Tafenoquine versus primaquine to prevent relapse of plasmodium vivax malaria 
    Llanos Cuentas, Elmer Alejandro; Lacerda, M.V.G.; Hien, T.T.; Vélez, I.D.; Namaik-Larp, C.; Chu, C.S.; Villegas, M.F.; Val, F.; Monteiro, W.M.; Brito, M.A.M.; Costa, M.R.F.; Chuquiyauri, R.; Casapía, M.; Nguyen, C.H.; Aruachan, S.; Papwijitsil, R.; Nosten, F.H.; Bancone, G.; Angus, B.; Duparc, S.; Craig, G.; Rousell, V.M.; Jones, S.W.; Hardaker, E.; Clover, D.D.; Kendall, L.; Mohamed, K.; Koh, G.C.K.W.; Wilches, V.M.; Breton, J.J.; Green, J.A. (Massachusetts Medical Society, 2019)
    BACKGROUND: Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has been associated with relapse prevention through the clearance of P. vivax parasitemia and hypnozoites, termed "radical cure." METHODS: We ...

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