Browsing by Subject "Extracellular Matrix Proteins/metabolism"

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Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis

Ong, Catherine W. M.; Elkington, Paul T.; Brilha, Sara; Ugarte Gil, Cesar Augusto; Tome-Esteban, Maite T.; Tezera, Liku B.; Pabisiak, Przemyslaw J.; Moores, Rachel C.; Sathyamoorthy, Tarangini; Patel, Vimal; Gilman, Robert Hugh; Porter, Joanna C.; Friedland, Jon S. (Public Library of Science, 2015)

Pulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix destruction resulting in cavitation is not well ...

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