Listar por autor "Giacani, Lorenzo"

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  • High-throughput nanopore sequencing of Treponema pallidum tandem repeat genes arp and tp0470 reveals clade-specific patterns and recapitulates global whole genome phylogeny 
    Lieberman, Nicole A. P.; Armstrong, Thaddeus D.; Chung, Benjamin; Pfalmer, Daniel; Hennelly, Christopher M.; Haynes, Austin; Romeis, Emily; Wang, Qian-Qiu; Zhang, Rui-Li; Kou, Cai-Xia; Ciccarese, Giulia; Conte, Ivano Dal; Cusini, Marco; Drago, Francesco; Nakayama, Shu-Ichi; Lee, Kenichi; Ohnishi, Makoto; Konda, Kelika A.; Vargas Rivera, Silver Keith; Eguiluz, Maria; Caceres Palacios, Carlos Fernando; Klausner, Jeffrey D.; Mitja, Oriol; Rompalo, Anne; Mulcahy, Fiona; Hook, Edward W. 3rd; Hoffman, Irving F.; Matoga, Mitch M.; Zheng, Heping; Yang, Bin; Lopez-Medina, Eduardo; Ramirez, Lady G; Radolf, Justin D.; Hawley, Kelly L.; Salazar, Juan C.; Lukehart, Sheila A.; Sena, Arlene C.; Parr, Jonathan B.; Giacani, Lorenzo; Greninger, Alexander L. (Frontiers Media, 2022)
    Sequencing of most Treponema pallidum genomes excludes repeat regions in tp0470 and the tp0433 gene, encoding the acidic repeat protein (arp). As a first step to understanding the evolution and function of these genes and ...
  • The molecular epidemiology of Treponema pallidum subspecies pallidum 
    Ma, Daphne Y.; Giacani, Lorenzo; Centurion-Lara, Arturo (CSIRO Publishing, 2015)
    Pathogens adapt and evolve in response to pressures exerted by host environments, leading to generation of genetically diverse variants. Treponema pallidum subspecies pallidum displays a substantial amount of interstrain ...
  • Transcriptional and immunological analysis of the putative outer membrane protein and vaccine candidate TprL of Treponema pallidum 
    Haynes, Austin M.; Fernandez, Mark; Romeis, Emily; Mitjà, Oriol; Konda, Kelika A.; Vargas Rivera, Silver Keith; Eguiluz, Maria; Caceres Palacios, Carlos Fernando; Klausner, Jeffrey D.; Giacani, Lorenzo (Public Library of Science, 2021)
    BACKGROUND: An effective syphilis vaccine should elicit antibodies to Treponema pallidum subsp. pallidum (T. p. pallidum) surface antigens to induce pathogen clearance through opsonophagocytosis. Although the combination ...
  • Treponema pallidum Lipoprotein TP0435 Expressed in Borrelia burgdorferi Produces Multiple Surface/Periplasmic Isoforms and mediates Adherence 
    Chan, Kamfai; Nasereddin, Thayer; Alter, Laura; Centurion-Lara, Arturo; Giacani, Lorenzo; Parveen, Nikhat (Springer Nature, 2016)
    The ability of Treponema pallidum, the syphilis spirochete to colonize various tissues requires the presence of surface-exposed adhesins that have been difficult to identify due to the inability to culture and genetically ...

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