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Browsing by Subject "Macrophages/drug effects"

Browsing by Subject "Macrophages/drug effects"

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  • In vitro and in vivo activity of benzocphenanthridines against Leishmania amazonensis 
    Castillo Pareja, Denis Helan; Sauvain, Michel Henri Auguste; Rivaud, Marion; Jullian, Valérie (Georg Thieme Verlag, 2014)
    Seven benzo[c]phenanthridines, synthetic or isolated from Zanthoxylum rhoifolium root bark, were evaluated against Leishmania amazonensis axenic amastigotes. Five of them were considered leishmanicidal, with IC50 values ...
  • Leishmanicidal compounds and potent PPARγ activators from Renealmia thyrsoidea 
    Cabanillas Amado, Billy Joel; Le Lamer, Anne-Cecile; Olagnier, David; Castillo Pareja, Denis Helan; Arévalo Zelada, Jorge Luis; Valadeau, Celine; Coste, Agnes; Pipy, Bernard; Bourdy, Genevieve; Sauvain, Michel Henri Auguste; Fabre, Nicolas (Elsevier, 2014)
    ETHNOPHARMACOLOGICAL RELEVANCE: Leaves and rhizomes of Renealmia thyrsoidea (Ruiz & Pav.) Poepp. & Endl. traditionally used in the Yanesha pharmacopoeia to treat skin infections such as leishmaniasis ulcers, or to reduce ...
  • Synthesis, antileishmanial activity and cytotoxicity of 2,3-diaryl- and 2,3,8-trisubstituted imidazo[1,2-a]pyrazines 
    Marchand, Pascal; Bazin, Marc-Antoine; Pagniez, Fabrice; Riviere, Guillaume; Bodero, Lizeth; Marhadour, Sophie; Nourrisson, Marie-Renee; Picot, Carine; Ruchaud, Sandrine; Bach, Stephane; Baratte, Blandine; Sauvain, Michel Henri Auguste; Pareja, Denis Castillo; Vaisberg Wollach, Abraham Jaime; Le Pape, Patrice (Elsevier, 2015)
    A series of original 2-phenyl-3-(pyridin-4-yl)imidazo[1,2-a]pyrazines and the 3-iodo precursors, bearing a polar moiety at the C-8 position, was synthesized and evaluated for their antileishmanial activities. Two derivatives ...

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