Universidad Peruana Cayetano Heredia

Store-operated channels in the pulmonary circulation of high- and low-altitude neonatal lambs

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dc.contributor.author Parrau, Daniela
dc.contributor.author Ebensperger, Germán
dc.contributor.author Herrera, Emilio A.
dc.contributor.author Moraga, Fernanda
dc.contributor.author Riquelme, Raquel A.
dc.contributor.author Ulloa, César E.
dc.contributor.author Rojas, Rodrigo T.
dc.contributor.author Silva, Pablo
dc.contributor.author Hernandez, Ismael
dc.contributor.author Ferrada, Javiera
dc.contributor.author Diaz, Marcela
dc.contributor.author Parer, Julian T.
dc.contributor.author Cabello, Gertrudis
dc.contributor.author Llanos, Aníbal J.
dc.contributor.author Reyes, Roberto V.
dc.date.accessioned 2022-01-04T20:29:53Z
dc.date.available 2022-01-04T20:29:53Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10365
dc.description.abstract We determined whether store-operated channels (SOC) are involved in neonatal pulmonary artery function under conditions of acute and chronic hypoxia, using newborn sheep gestated and born either at high altitude (HA, 3,600 m) or low altitude (LA, 520 m). Cardiopulmonary variables were recorded in vivo, with and without SOC blockade by 2-aminoethyldiphenylborinate (2-APB), during basal or acute hypoxic conditions. 2-APB did not have effects on basal mean pulmonary arterial pressure (mPAP), cardiac output, systemic arterial blood pressure, or systemic vascular resistance in both groups of neonates. During acute hypoxia 2-APB reduced mPAP and pulmonary vascular resistance in LA and HA, but this reduction was greater in HA. In addition, isolated pulmonary arteries mounted in a wire myograph were assessed for vascular reactivity. HA arteries showed a greater relaxation and sensitivity to SOC blockers than LA arteries. The pulmonary expression of two SOC-forming subunits, TRPC4 and STIM1, was upregulated in HA. Taken together, our results show that SOC contribute to hypoxic pulmonary vasoconstriction in newborn sheep and that SOC are upregulated by chronic hypoxia. Therefore, SOC may contribute to the development of neonatal pulmonary hypertension. We propose SOC channels could be potential targets to treat neonatal pulmonary hypertension. en_US
dc.language.iso eng
dc.publisher American Physiological Society
dc.relation.ispartofseries American Journal of Physiology - Lung Cellular and Molecular Physiology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject animal en_US
dc.subject genetics en_US
dc.subject unclassified drug en_US
dc.subject controlled study en_US
dc.subject priority journal en_US
dc.subject altitude disease en_US
dc.subject Altitude Sickness en_US
dc.subject blood en_US
dc.subject physiology en_US
dc.subject altitude en_US
dc.subject arterial pressure en_US
dc.subject lung artery pressure en_US
dc.subject pulmonary artery en_US
dc.subject anoxia en_US
dc.subject pathophysiology en_US
dc.subject article en_US
dc.subject hypoxia en_US
dc.subject Infant, Newborn en_US
dc.subject newborn en_US
dc.subject drug effect en_US
dc.subject ex vivo study en_US
dc.subject disease model en_US
dc.subject in vivo study en_US
dc.subject Sheep, Domestic en_US
dc.subject 2-aminoethyl diphenylborinate en_US
dc.subject blood vessel reactivity en_US
dc.subject boron derivative en_US
dc.subject calcium channel en_US
dc.subject cardiopulmonary function en_US
dc.subject heart output en_US
dc.subject hemodynamics en_US
dc.subject hypoxic lung vasoconstriction en_US
dc.subject ion channel en_US
dc.subject Ion Channels en_US
dc.subject isolated organ en_US
dc.subject lamb en_US
dc.subject lung circulation en_US
dc.subject lung vascular resistance en_US
dc.subject Persistent Fetal Circulation Syndrome en_US
dc.subject persistent pulmonary hypertension en_US
dc.subject Pulmonary Circulation en_US
dc.subject Pulmonary hypertension en_US
dc.subject Pulmonary vascular reactivity en_US
dc.subject Pulmonary vasoconstriction en_US
dc.subject sheep en_US
dc.subject store operated channel en_US
dc.subject systemic vascular resistance en_US
dc.subject transient receptor potential channel C en_US
dc.subject TRPC Cation Channels en_US
dc.subject TRPC4 ion channel en_US
dc.subject vasoconstriction en_US
dc.subject Vasoconstriction en_US
dc.title Store-operated channels in the pulmonary circulation of high- and low-altitude neonatal lambs en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1152/ajplung.00024.2012
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.08
dc.relation.issn 1522-1504


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