Universidad Peruana Cayetano Heredia

Expression of minichromosome maintenance 2, Ki-67, and geminin in oral nevi and melanoma

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dc.contributor.author De Andrade, Bruno Augusto Benvenuto
dc.contributor.author León, Jorge Esquiche
dc.contributor.author Carlos, Román
dc.contributor.author Delgado-Azañero, Wilson
dc.contributor.author Mosqueda-Taylor, Adalberto
dc.contributor.author De Almeida, Oslei Paes
dc.date.accessioned 2022-01-04T20:29:54Z
dc.date.available 2022-01-04T20:29:54Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10372
dc.description.abstract Evaluation of cell cycle using antibodies against nuclear proteins involved in regulating DNA replication has gained special interest in the effort to predict biologic behavior of benign and malignant tumors. The aim of this study was to analyze the expression of minichromosome maintenance 2, Ki-67, and geminin in oral nevi and melanomas. Expression of these cell proliferation markers was evaluated by immunohistochemistry in 49 oral melanocytic lesions, including 38 intramucosal nevi and 11 primary oral melanomas. The labeling index of each proliferation marker was assessed considering the percentage of cells expressing nuclear positivity out of the total number of cells, counting 1000 cells per slide. Minichromosome maintenance 2, Ki-67, and geminin were rarely expressed in intramucosal nevi, in contrast to oral melanomas, which showed high levels of these cell proliferation markers, particularly minichromosome maintenance 2, indicating it is a more sensitive marker in primary oral melanomas than Ki-67 and geminin. These results indicate that these markers may be involved in the pathogenesis of oral melanomas and could be eventually useful as an additional diagnostic tool for differential diagnosis of oral benign and malignant melanocytic lesions. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Annals of Diagnostic Pathology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject human en_US
dc.subject controlled study en_US
dc.subject Young Adult en_US
dc.subject priority journal en_US
dc.subject Retrospective Studies en_US
dc.subject Diagnosis, Differential en_US
dc.subject human tissue en_US
dc.subject protein expression en_US
dc.subject immunohistochemistry en_US
dc.subject pathogenesis en_US
dc.subject cell proliferation en_US
dc.subject Cell Proliferation en_US
dc.subject Immunohistochemistry en_US
dc.subject Mouth Neoplasms en_US
dc.subject Tumor Markers, Biological en_US
dc.subject melanoma en_US
dc.subject Oral melanoma en_US
dc.subject Oral nevi en_US
dc.subject Cell Cycle Proteins en_US
dc.subject geminin en_US
dc.subject Gene Expression Regulation, Neoplastic en_US
dc.subject Ki 67 antigen en_US
dc.subject Ki-67 en_US
dc.subject Ki-67 Antigen en_US
dc.subject labeling index en_US
dc.subject Mcm-2 en_US
dc.subject melanocyte en_US
dc.subject melanocytic nevus en_US
dc.subject minichromosome maintenance protein 2 en_US
dc.subject Nevus, Pigmented en_US
dc.subject Nuclear Proteins en_US
dc.subject oral melanoma en_US
dc.subject oral nevus en_US
dc.title Expression of minichromosome maintenance 2, Ki-67, and geminin in oral nevi and melanoma en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.anndiagpath.2012.05.001
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.09
dc.relation.issn 1532-8198


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