Universidad Peruana Cayetano Heredia

Human host-derived cytokines associated with Plasmodium vivax transmission from acute malaria patients to Anopheles darlingi mosquitoes in the Peruvian Amazon

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dc.contributor.author Abeles, Shira R.
dc.contributor.author Chuquiyauri, Raul
dc.contributor.author Tong, Chuquiyauri
dc.contributor.author Vinetz, Joseph Michael
dc.date.accessioned 2022-01-04T20:33:20Z
dc.date.available 2022-01-04T20:33:20Z
dc.date.issued 2013
dc.identifier.uri https://hdl.handle.net/20.500.12866/10761
dc.description.abstract Infection of mosquitoes by humans is not always successful in the setting of patent gametocytemia. This study tested the hypothesis that pro- or anti-inflammatory cytokines are associated with transmission of Plasmodium vivax to Anopheles darlingi mosquitoes in experimental infection. Blood from adults with acute, non-severe P. vivax malaria was fed to laboratory-reared F1 An. darlingi mosquitoes. A panel of cytokines at the time of mosquito infection was assessed in patient sera and levels compared among subjects who did and did not infect mosquitoes. Overall, blood from 43 of 99 (43%) subjects led to mosquito infection as shown by oocyst counts. Levels of IL-10, IL-6, TNF-α, and IFN-γ were significantly elevated in vivax infection and normalized 3 weeks later. The anti-inflammatory cytokine IL-10 was significantly higher in nontransmitters compared with top transmitters but was not in TNF-α and IFN-γ. The IL-10 elevation during acute malaria was associated with P. vivax transmission blocking. en_US
dc.language.iso eng
dc.publisher American Society of Tropical Medicine and Hygiene
dc.relation.ispartofseries American Journal of Tropical Medicine and Hygiene
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Animals en_US
dc.subject Humans en_US
dc.subject major clinical study en_US
dc.subject Peru en_US
dc.subject adolescent en_US
dc.subject interleukin 4 en_US
dc.subject interleukin 5 en_US
dc.subject blood en_US
dc.subject clinical assessment en_US
dc.subject Cytokines en_US
dc.subject fever en_US
dc.subject disease transmission en_US
dc.subject follow up en_US
dc.subject Malaria, Vivax en_US
dc.subject Parasitemia en_US
dc.subject Plasmodium vivax en_US
dc.subject Plasmodium vivax malaria en_US
dc.subject Host-Parasite Interactions en_US
dc.subject Insect Vectors en_US
dc.subject cytokine response en_US
dc.subject gamma interferon en_US
dc.subject Interferon-gamma en_US
dc.subject interleukin 10 en_US
dc.subject Interleukin-10 en_US
dc.subject tumor necrosis factor alpha en_US
dc.subject Tumor Necrosis Factor-alpha en_US
dc.subject Malaria en_US
dc.subject Anopheles en_US
dc.subject Anopheles darlingi en_US
dc.subject oocyst en_US
dc.subject interleukin 6 en_US
dc.subject Interleukin-6 en_US
dc.subject interleukin 1beta en_US
dc.subject interleukin 8 en_US
dc.subject interleukin 2 en_US
dc.subject granulocyte macrophage colony stimulating factor en_US
dc.title Human host-derived cytokines associated with Plasmodium vivax transmission from acute malaria patients to Anopheles darlingi mosquitoes in the Peruvian Amazon en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.4269/ajtmh.12-0752
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1476-1645


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