Universidad Peruana Cayetano Heredia

A high oxfendazole dose to control porcine cysticercosis: Pharmacokinetics and tissue residue profiles

Mostrar el registro sencillo del ítem

dc.contributor.author Moreno, L.
dc.contributor.author Lopez-Urbina, M.T.
dc.contributor.author Farias, C.
dc.contributor.author Domingue, G.
dc.contributor.author Donadeu, M.
dc.contributor.author Dungu, B.
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author Gomez-Puerta, L.A.
dc.contributor.author Lanusse, C.
dc.contributor.author Gonzalez Zariquiey, Armando Emiliano
dc.date.accessioned 2022-01-18T19:26:46Z
dc.date.available 2022-01-18T19:26:46Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10857
dc.description.abstract Oxfendazole (OFZ) is efficacious for porcine cysticercosis at 30mg/kg. OFZ is not registered to be used at this dose. The assessment of the OFZ and metabolites [(fenbendazole sulphone (FBZSO2), fenbendazole (FBZ)] plasma pharmacokinetic and tissue residue profiles after its oral administration to pigs and the withdrawal period for human consumption were reported. Forty-eight pigs allocated into two groups received OFZ (30mg/kg) orally as a commercial (CF) or as experimental formulation (SMF). Samples (blood, muscle, liver, kidney and fat) were collected over 30days post-treatment and analyzed by HPLC. OFZ was the main compound recovered in plasma, followed by FBZSO2 and low FBZ concentrations. OFZ AUC0-LOQ (209.9±33.9μg·h/ml) and Cmax (5.40±0.65μg/ml) parameters for the CF tended to be higher than those for the SMF (AUC0-LOQ: 159.4±18.3μgh/ml, Cmax: 3.80±0.35μg/ml). The highest total residue (OFZ+FBZSO2+FBZ) concentrations were quantified in liver, followed by kidney, muscle and fat tissue. FBZSO2 residue levels were the highest found in muscle (0.68±0.39μg/g) and fat (0.69±0.39μg/g). In liver and kidney the highest residues corresponded to FBZ (5.29±4.36μg/g) and OFZ (2.86±0.75μg/g), respectively. A withdrawal time of 17days post-treatment was established before tissues are delivered for human consumption. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Food and Chemical Toxicology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Male en_US
dc.subject Controlled Study en_US
dc.subject Animal Experiment en_US
dc.subject Food Intake en_US
dc.subject Blood Sampling en_US
dc.subject Anthelmintics en_US
dc.subject Cysticercosis en_US
dc.subject Swine Diseases en_US
dc.subject Benzimidazoles en_US
dc.subject Dose-Response Relationship Drug en_US
dc.subject Area Under Curve en_US
dc.subject High Performance Liquid Chromatography en_US
dc.subject Liver en_US
dc.subject Kidney en_US
dc.subject Adipose Tissue en_US
dc.subject Drug Residues en_US
dc.subject Fenbendazole Sulphone en_US
dc.subject |Pharmacokinetics en_US
dc.title A high oxfendazole dose to control porcine cysticercosis: Pharmacokinetics and tissue residue profiles en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.fct.2012.07.023
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.07
dc.relation.issn 1873-6351


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas