Universidad Peruana Cayetano Heredia

Attenuated CagA oncoprotein in Helicobacter pylori from Amerindians in Peruvian Amazon

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dc.contributor.author Suzuki, M.
dc.contributor.author Kiga, K.
dc.contributor.author Kersulyte, D.
dc.contributor.author Cok, J.
dc.contributor.author Hooper, C.C.
dc.contributor.author Mimuro, H.
dc.contributor.author Sanada, T.
dc.contributor.author Suzuki, S.
dc.contributor.author Oyama, M.
dc.contributor.author Kozuka-Hata, H.
dc.contributor.author Kamiya, S.
dc.contributor.author Zou, Q.-M.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Berg, D.E.
dc.contributor.author Sasakawa, C.
dc.date.accessioned 2022-01-18T19:26:50Z
dc.date.available 2022-01-18T19:26:50Z
dc.date.issued 2011
dc.identifier.uri https://hdl.handle.net/20.500.12866/10928
dc.description.abstract Population genetic analyses of bacterial genes whose products interact with host tissues can give new understanding of infection and disease processes. Here we show that strains of the genetically diverse gastric pathogen Helicobacter pylori from Amerindians from the remote Peruvian Amazon contain novel alleles of cagA, a major virulence gene, and reveal distinctive properties of their encoded CagA proteins. CagA is injected into the gastric epithelium where it hijacks pleiotropic signaling pathways, helps Hp exploit its special gastric mucosal niche, and affects the risk that infection will result in overt gastroduodenal diseases including gastric cancer. The Amerindian CagA proteins contain unusual but functional tyrosine phosphorylation motifs and attenuated CRPIA motifs, which affect gastric epithelial proliferation, inflammation, and bacterial pathogenesis. Amerindian CagA proteins induced less production of IL-8 and cancer-associated Mucin 2 than did those of prototype Western or East Asian strains and behaved as dominant negative inhibitors of action of prototype CagA during mixed infection of Mongolian gerbils. We suggest that Amerindian cagA is of relatively low virulence, that this may have been selected in ancestral strains during infection of the people who migrated from Asia into the Americas many thousands of years ago, and that such attenuated CagA proteins could be useful therapeutically. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Journal of Biological Chemistry
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Humans en_US
dc.subject Peru en_US
dc.subject Controlled Study en_US
dc.subject Helicobacter Infection en_US
dc.subject Helicobacter Pylori en_US
dc.subject Intestine Metaplasia en_US
dc.subject Human Tissue en_US
dc.subject Nucleotide Sequence en_US
dc.subject Inflammation en_US
dc.subject Amino Acid Sequence en_US
dc.subject Clinical |Molecular Sequence Data en_US
dc.subject American Indian en_US
dc.subject Indians South American en_US
dc.subject Evolution Molecular en_US
dc.subject Signal Transduction en_US
dc.subject Bacterial Proteins en_US
dc.subject Infection Risk en_US
dc.subject Cytokine Production en_US
dc.subject Interleukin 8 en_US
dc.subject Bacterial Gene en_US
dc.subject Bacteria (Microorganisms) en_US
dc.subject Virulence Factors en_US
dc.subject Cell Proliferation en_US
dc.subject Pathogenesis en_US
dc.subject Stomach Neoplasms en_US
dc.subject Bacterial Strain en_US
dc.subject Antigens Bacterial en_US
dc.subject Gastric Mucosa en_US
dc.subject Alleles en_US
dc.subject Amerindians en_US
dc.subject Amino Acid Motifs en_US
dc.subject Bacterial Pathogenesis en_US
dc.subject Bacteriology en_US
dc.subject Caga Gene en_US
dc.subject Caga Protein en_US
dc.subject Disease Process en_US
dc.subject Dominant Negative en_US
dc.subject Epithelial Proliferation en_US
dc.subject Gastric Cancers en_US
dc.subject Gastritis en_US
dc.subject Genes en_US
dc.subject Gerbil en_US
dc.subject Gerbillinae en_US
dc.subject Host Tissues en_US
dc.subject Interleukin-8 en_US
dc.subject Ion Beams en_US
dc.subject Meriones Unguiculatus en_US
dc.subject Mixed Infections en_US
dc.subject Mucin 2 en_US
dc.subject Mucin-2 en_US
dc.subject Oncoproteins en_US
dc.subject Phosphorylation en_US
dc.subject Population Genetic Analysis en_US
dc.subject Protein Motif en_US
dc.subject Protein Phosphorylation en_US
dc.subject Signaling Pathways en_US
dc.subject Stomach Biopsy en_US
dc.subject Stomach Epithelium en_US
dc.subject Stomach Mucosa en_US
dc.subject Tissue en_US
dc.subject Tyrosine Phosphorylation en_US
dc.subject Virulence Gene en_US
dc.title Attenuated CagA oncoprotein in Helicobacter pylori from Amerindians in Peruvian Amazon en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1074/jbc.M111.263715
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.00
dc.relation.issn 1083-351X


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