Universidad Peruana Cayetano Heredia
Aspergilosis pulmonar secundaria a neutropenia inducida por metimazol: reporte de un caso
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| dc.contributor.author | Pinto, M.E. | |
| dc.contributor.author | Banda Flores, Claudia Lizette | |
| dc.contributor.author | Seas Ramos, Carlos Rafael | |
| dc.date.accessioned | 2022-01-18T19:34:43Z | |
| dc.date.available | 2022-01-18T19:34:43Z | |
| dc.date.issued | 2012 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/11177 | |
| dc.description.abstract | A 48-year old woman with a recent diagnosis of Graves' disease arrived at the emergency room with fever, palpitations, and a sore throat. Her regular treatment included methimazole. On admission, laboratory results showed suppressed TSH, elevated free thyroxine, and neutropenia. She was admitted and started on antibiotics and granulocyte-macrophage colony stimulating factor (gm-csf). After ten days, the patient developed leukocytosis, fever, and hemoptysis. Chest CT scan showed a lung cavity with multiple nodules in the upper right lobe. Cultures from a lung biopsy were positive for Aspergillus Fumigatus and Aspergillus Flavus. Amphotericin B was started but then switched to voriconazole, with both treatments failing to result in clinical improvement. The patient died of multi-organ failure. | en_US |
| dc.description.abstract | Se reporta el caso de una paciente de 48 años de edad con diagnóstico reciente de enfermedad de Graves, quien acudió a emergencia por presentar fiebre, palpitaciones y dolor faríngeo. Su tratamiento regular incluía metimazol. Al ingreso, los análisis mostraron TSH suprimido, T4 libre elevado y neutropenia. La paciente fue hospitalizada, se administraron antibióticos y factor estimulante de colonia. Después de diez días de tratamiento, la paciente presentó leucocitosis, fiebre y hemoptisis. La tomografía de tórax mostró una cavidad con múltiples nódulos en el lóbulo superior derecho. Los cultivos fueron positivos a Aspergillus fumigatus y Aspergillus flavus. Se inició tratamiento con anfotericina B y luego se cambió a voriconazol, a pesar de lo cual no hubo mejoría del cuadro. La paciente falleció por falla multiorgánica. | es_PE |
| dc.language.iso | spa | |
| dc.language.iso | eng | |
| dc.publisher | Instituto Nacional de Salud | |
| dc.relation.ispartofseries | Revista Peruana de Medicina Experimental y Salud Pública | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Case report | en_US |
| dc.subject | fever | en_US |
| dc.subject | mortality | en_US |
| dc.subject | neutropenia | en_US |
| dc.subject | computer assisted tomography | en_US |
| dc.subject | granulocyte macrophage colony stimulating factor | en_US |
| dc.subject | laboratory test | en_US |
| dc.subject | hemoptysis | en_US |
| dc.subject | multiple organ failure | en_US |
| dc.subject | heart palpitation | en_US |
| dc.subject | voriconazole | en_US |
| dc.subject | drug treatment failure | en_US |
| dc.subject | amphotericin B | en_US |
| dc.subject | hospital admission | en_US |
| dc.subject | emergency ward | en_US |
| dc.subject | antibiotic agent | en_US |
| dc.subject | drug substitution | en_US |
| dc.subject | drug withdrawal | en_US |
| dc.subject | fungus culture | en_US |
| dc.subject | thyrotropin | en_US |
| dc.subject | Graves disease | en_US |
| dc.subject | Aspergillus | en_US |
| dc.subject | thyroxine | en_US |
| dc.subject | sore throat | en_US |
| dc.subject | Neutropenia | en_US |
| dc.subject | Antithyroid agents | en_US |
| dc.subject | Aspergillus flavus | en_US |
| dc.subject | Aspergillus fumigatus | en_US |
| dc.subject | leukocytosis | en_US |
| dc.subject | lung aspergillosis | en_US |
| dc.subject | lung nodule | en_US |
| dc.subject | Methimazole | en_US |
| dc.subject | Pulmonary aspergillosis | en_US |
| dc.subject | thiamazole | en_US |
| dc.title | Aspergilosis pulmonar secundaria a neutropenia inducida por metimazol: reporte de un caso | es_PE |
| dc.title.alternative | Pulmonary aspergillosis Due to methimazole-induced neutropenia: A case report | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1590/S1726-46342012000200015 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.05 | |
| dc.relation.issn | 1726-4642 |
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