Universidad Peruana Cayetano Heredia

Cholera-Brucella cross-reaction: A new potential diagnostic problem for travelers to Latin America

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dc.contributor.author Goicochea, Carlos E.
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Carrillo, Carlos
dc.date.accessioned 2022-10-10T00:48:55Z
dc.date.available 2022-10-10T00:48:55Z
dc.date.issued 1996
dc.identifier.uri https://hdl.handle.net/20.500.12866/12318
dc.description.abstract Background: Brucellosis is an endemic disease in Latin America and other countries. Serologic cross-reaction between cholera and Brucella infection is well recognized. Since the introduction to cholera in 1991 in Latin America, interpreting serologic tests has become potentially problematic. This study attempts to evaluate this problem. Methods: Tube agglutination tests were performed to detect Brucella antibodies in 44 Peruvian adult patients with moderate to severe diarrhea due to Vibrio cholerae O1 El Tor infection. These patients had no prior history and no clinical evidence of brucellosis. Results: False positive reactions were observed in 43.2% and 15.9% of the patients when cut-off points of ≥ 1/80 and ≥ 1/160 titer, respectively, were selected. These false positive reactions occurred within 4 to 14 days after the onset of diarrhea. The cross-reactivity decreased at the end of the fifth week (only 8.33% had a positive value at the fifth week).Conclusions: Physicians should be alert to the false positive reaction to Brucella in patients with diarrhea. This is relevant to the evaluation of febrile illness in patients coming from developing countries where they could have been exposed to cholera. en_US
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartofseries Journal of Travel Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject brucellosis en_US
dc.subject cholera en_US
dc.subject diarrhea en_US
dc.subject fever en_US
dc.subject adult en_US
dc.subject brucella en_US
dc.subject cross reactions en_US
dc.subject developing countries en_US
dc.subject endemic diseases en_US
dc.subject false positive reactions en_US
dc.subject latin america en_US
dc.subject serologic tests en_US
dc.subject infections en_US
dc.subject antibodies en_US
dc.subject diagnosis en_US
dc.subject traveler en_US
dc.subject symptom onset en_US
dc.subject vibrio cholerae en_US
dc.subject agglutination tests en_US
dc.title Cholera-Brucella cross-reaction: A new potential diagnostic problem for travelers to Latin America en_US
dc.title.alternative Reacción cruzada cólera-brucela: Un nuevo problema potencial de diagnóstico para los viajeros a América Latina es_PE
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/j.1708-8305.1996.tb00694.x
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1708-8305


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