Universidad Peruana Cayetano Heredia

The global prevalence of human fascioliasis: a systematic review and meta-analysis

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dc.contributor.author Rosas-Hostos Infantes, Luis Raúl
dc.contributor.author Paredes Yataco, Guillermo Andres
dc.contributor.author Ortiz-Martínez, Yeimer
dc.contributor.author Mayer, Treana
dc.contributor.author Terashima Iwashita de Ponce, Maria Angelica
dc.contributor.author Franco-Paredes, Carlos
dc.contributor.author Gonzalez-Diaz, Esteban
dc.contributor.author Rodriguez-Morales, Alfonso J.
dc.contributor.author Bonilla-Aldana, D. Katterine
dc.contributor.author Vargas Barahona, Lilian
dc.contributor.author Grimshaw, Alyssa A.
dc.contributor.author Chastain, Daniel B.
dc.contributor.author Sillau, Stefan
dc.contributor.author Marcos, Luis A.
dc.contributor.author Henao-Martínez, Andrés F.
dc.date.accessioned 2023-09-06T20:45:07Z
dc.date.available 2023-09-06T20:45:07Z
dc.date.issued 2023
dc.identifier.uri https://hdl.handle.net/20.500.12866/14053
dc.description.abstract Background: Fascioliasis is a parasitic zoonosis that can infect humans and be a source of significant morbidity. The World Health Organization lists human fascioliasis as a neglected tropical disease, but the worldwide prevalence of fascioliasis data is unknown. Objective: We aimed to estimate the global prevalence of human fascioliasis. Data sources and methods: We performed a systematic review and prevalence meta-analysis. We used the following inclusion criteria: articles published in the English, Portuguese, or Spanish languages from December 1985 to October 2022 and studies assessing the prevalence of Fasciola in the general population with an appropriate diagnostic methodology, including longitudinal studies, prospective and retrospective cohorts, case series, and randomized clinical trials (RCTs). We excluded animal studies. Two reviewers independently reviewed the selected studies for methodological quality, performing critical standard measures from JBI SUMARI. A random-effects model was conducted of the summary extracted data on the prevalence proportions. We reported the estimates according to the GATHER statement. Results: In all, 5617 studies were screened for eligibility. Fifty-five studies from 15 countries were selected, including 154,697 patients and 3987 cases. The meta-analysis revealed a pooled prevalence of 4.5% [95% confidence interval (CI): 3.1–6.1; I2 = 99.4%; T2 = 0.07]. The prevalence in South America, Africa, and Asia was 9.0%, 4.8%, and 2.0%, respectively. The highest prevalence was found in Bolivia (21%), Peru (11%), and Egypt (6%). Subgroup analysis showed higher prevalence estimates in children, in studies from South America, and when Fas2-enzyme-linked immunosorbent assay (ELISA) was used as a diagnostic method. A larger study sample size (p = 0.027) and an increase in female percentage (p = 0.043) correlated with a decrease in prevalence. Multiple meta-regression showed a higher prevalence for hyperendemic than hypoendemic (p = 0.002) or mesoendemic (p = 0.013) regions. Conclusion: The estimated prevalence and projected disease burden of human fascioliasis are high. Study findings support that fascioliasis continues to be a globally neglected tropical disease. Strengthening epidemiological surveillance and implementing measures to control and treat fascioliasis is imperative in the most affected areas. en_US
dc.language.iso eng
dc.publisher Sage Publications
dc.relation.ispartofseries Therapeutic Advances in Infectious Disease
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Human fascioliasis en_US
dc.subject Systematic review en_US
dc.subject Meta-analysis en_US
dc.subject.mesh Fascioliasis
dc.subject.mesh Revisión Sistemática
dc.subject.mesh Metaanálisis
dc.title The global prevalence of human fascioliasis: a systematic review and meta-analysis en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1177/20499361231185413
dc.relation.issn 2049-937X


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