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The increase in hemoglobin concentration with altitude varies among human populations.

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dc.contributor.author Gassmann, Max
dc.contributor.author Mairbaurl, Heimo
dc.contributor.author Livshits, Leonid
dc.contributor.author Seide, Svenja
dc.contributor.author Hackbusch, Matthes
dc.contributor.author Malczyk, Monika
dc.contributor.author Kraut, Simone
dc.contributor.author Gassmann, Norina N.
dc.contributor.author Weissmann, Norbert
dc.contributor.author Muckenthaler, Martina U.
dc.date.accessioned 2019-08-08T15:23:44Z
dc.date.available 2019-08-08T15:23:44Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/20.500.12866/7125
dc.description.abstract Decreased oxygen availability at high altitude requires physiological adjustments allowing for adequate tissue oxygenation. One such mechanism is a slow increase in the hemoglobin concentration ([Hb]) resulting in elevated [Hb] in high-altitude residents. Diagnosis of anemia at different altitudes requires reference values for [Hb]. Our aim was to establish such values based on published data of residents living at different altitudes by applying meta-analysis and multiple regressions. Results show that [Hb] is increased in all high-altitude residents. However, the magnitude of increase varies among the regions analyzed and among ethnic groups within a region. The highest increase was found in residents of the Andes (1 g/dL/1000 m), but this increment was smaller in all other regions of the world (0.6 g/dL/1000 m). While sufficient data exist for adult males and females showing that sex differences in [Hb] persist with altitude, data for infants, children, and pregnant women are incomplete preventing such analyses. Because WHO reference values were originally based on [Hb] of South American people, we conclude that individual reference values have to be defined for ethnic groups to reliably diagnose anemia and erythrocytosis in high-altitude residents. Future studies need to test their applicability for children of different ages and pregnant women. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Annals of the New York Academy of Sciences
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject anemia en_US
dc.subject excessive erythrocytosis en_US
dc.subject pregnancy en_US
dc.subject infants en_US
dc.subject ethnicity en_US
dc.subject newborns en_US
dc.title The increase in hemoglobin concentration with altitude varies among human populations. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/nyas.14136
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.00
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.04
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#6.01.01
dc.relation.issn 1749-6632


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