Listar por tema "genotype"

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  • Montalva, Nicolás; Adhikari, Kaustubh; Liebert, Anke; Mendoza-Revilla, Javier; Flores, Sergio V.; Mace, Ruth; Swallow, Dallas M. (Wiley, 2018)
    The genetic trait of lactase persistence (LP) evolved as an adaptation to milking pastoralism in the Old World and is a well-known example of positive natural selection in humans. However, the specific mechanisms conferring ...
  • Rath, Barbara A.; von Kleist, Max; Castillo, Maria E.; Kolevic, Lenka; Caballero, Patricia; Soto-Castellares, Giselle; Amedee, Angela M.; Robinson, James E.; Katzenstein, David K.; Van Dyke, Russell B.; Oberhelman, Richard A. (BioMed Central, 2013)
    Background: The impact of extended use of ART in developing countries has been enormous. A thorough understanding of all factors contributing to the success of antiretroviral therapy is required. The current study aims to ...
  • Nalvarte, R.Y.C.; Sayan, A.M.; Rodríguez Bailon, Jorge; Yanagui, Y.K. (Facultad de Medicina Veterinaria. Universidad Nacional Mayor de San Marcos, 2021)
    The aim of this study was the genotyping of Ornithobacterium rhinotracheale. For this, 36 strains were identified by molecular testing and genotyping was performed by Multilocus Sequence Typing (MLST). The tests identified ...
  • Soohoo, Melissa; Blas Blas, Magaly Marlitz; Byraiah, Gita; Cárcamo Cavagnaro, César Paul Eugenio; Brown, Brandon (Bentham Science Publishers, 2013)
    Approximately 291 million women worldwide are HPV DNA carriers. Studies have indicated that having multiple sexual partners may lead to higher HPV transmission…
  • Cornejo-Olivas, M.R.; Inca-Martinez, M.A.; Espinoza Huertas, Keren Antonieta; Veliz-Otani, D.; Velit-Salazar, M.R.; Marca, V.; Ortega, O.; Cornejo-Herrera, I.F.; Lindo-Samanamud, S.; Mora-Alferez, P.; Mazzetti, P. (IOS Press, 2015)
    Background: Late onset cases of Huntington disease (HD), with onset ≥60 years, account for up to 20% of HD cases worldwide. Clinical features include mild motor dysfunction with slow progression and cognitive impairment, ...
  • Sanjeev Kumar Sharma; Daniel Bolser; Jan de Boer; Mads Sønderkær; Walter Amoros; Martin Federico Carboni; Juan Martín D’Ambrosio; German de la Cruz; Alex Di Genova; David S Douches; Maria Eguiluz; Xiao Guo; Frank Guzman; Christine A Hackett; John P Hamilton; Guangcun Li; Ying Li; Roberto Lozano; Alejandro Maass; David Marshall; Diana Martinez; Karen McLean; Nilo Mejía; Linda Milne; Susan Munive; Istvan Nagy; Olga Ponce; Manuel Ramirez; Reinhard Simon; Susan J Thomson; Yerisf Torres; Robbie Waugh; Zhonghua Zhang; Sanwen Huang; Richard G F Visser; Christian W B Bachem; Boris Sagredo; Sergio E Feingold; Gisella Orjeda; Richard E Veilleux; Merideth Bonierbale; Jeanne M E Jacobs; Dan Milbourne; David Michael Alan Martin; Glenn J Bryan (Genetics Society of America, 2013)
    The genome of potato, a major global food crop, was recently sequenced. The work presented here details the integration of the potato reference genome (DM) with a new sequence-tagged site marker−based linkage map and other ...
  • Veldic, Marin; Ahmed, Ahmed T.; Blacker, Caren J.; Geske, Jennifer R.; Biernacka, Joanna M.; Borreggine, Kristin L.; Moore, Katherine M.; Prieto, Miguel L.; Vande Voort, Jennifer L.; Croarkin, Paul E.; Hoberg, Astrid A.; Kung, Simon; Alarcón, Renato D.; Keeth, Nicola; Singh, Balwinder; Bobo, William V.; Frye, Mark A. (Frontiers Media, 2019)
    Background: Pharmacogenomic testing, specifically for pharmacokinetic (PK) and pharmacodynamic (PD) genetic variation, may contribute to a better understanding of baseline genetic differences in patients seeking treatment ...
  • Mullins, K.E.; Hang, J.; Jiang, J.; Leguia, M.; Kasper, M.R.; Ventosilla, P.; Maguiña Vargas, Ciro; Jarman, R.G.; Blazes, D.; Richards, A.L. (Microbiology Society, 2015)
    Three novel isolates of the genus Bartonella were recovered from the blood of two patients enrolled in a clinical trial for the treatment of chronic stage Bartonella bacilliformis infection (verruga peruana) in Caraz, ...
  • Galanter, J.M.; Fernandez-Lopez, J.C.; Gignoux, C.R.; Barnholtz-Sloan, J.; Fernandez-Rozadilla, C.; Via, M.; Hidalgo-Miranda, A.; Contreras, A.V.; Figueroa, L.U.; Raska, P.; Jimenez-Sanchez, G.; Zolezzi, I.S.; Torres, M.; Ponte, C.R.; Ruiz, Y.; Salas, A.; Nguyen, E.; Eng, C.; Borjas, L.; Zabala, W.; Barreto, G.; González, F.R.; Ibarra, A.; Taboada, P.; Porras, L.; Moreno, F.; Bigham, A.; Gutierrez, G.; Brutsaert, T.; León-Velarde, Fabiola; Moore, L.G.; Vargas, E.; Cruz, M.; Escobedo, J.; Rodriguez-Santana, J.; Rodriguez-Cintrón, W.; Chapela, R.; Ford, J.G.; Bustamante, C.; Seminara, D.; Shriver, M.; Ziv, E.; Burchard, E.G.; Haile, R.; Parra, E.; Carracedo, A. (Public Library of Science, 2012)
    Most individuals throughout the Americas are admixed descendants of Native American, European, and African ancestors. Complex historical factors have resulted in varying proportions of ancestral contributions between ...
  • Acosta, F.; Agapito, J.; Cabibbe, A.M.; Cáceres Nakiche, Tatiana; Sola, C.; Pérez-Lago, L.; Abascal, E.; Herranz, M.; Meza, E.; Klotoe, B.; Muñoz, P.; Rossolini, G.M.; Bartoloni, A.; Tortoli, E.; Cirillo, D.M.; Gotuzzo Herencia, José Eduardo; García De Viedma, D. (Centers for Disease Control and Prevention, 2019)
    We performed a cross-border molecular epidemiology analysis of multidrug-resistant tuberculosis in Peru, Spain, and Italy. This analysis revealed frequent transmission in Peru and exportation of a strain that recreated ...
  • Román, Karina; Castillo, Rosa; Gilman, Robert Hugh; Calderón Sánchez, Maritza Mercedes; Vivar, Aldo; Céspedes, Manuel; Smits, Henk L.; Meléndez, Paolo; Gotuzzo Herencia, José Eduardo; Guerra, Humberto; Maves, Ryan C.; Matthias, Michael A.; Vinetz, Joseph Michael; Saito, Mayuko (American Society of Tropical Medicine and Hygiene, 2013)
    Brucella melitensis is highly infectious for humans and can be transmitted to humans in a number of epidemiological contexts. Within the context of an ongoing brucellosis surveillance project, an outbreak at a Peruvian ...
  • Macias-Kauffer, Luis R.; Villamil-Ramírez, Hugo; León-Mimila, Paola; Jacobo-Albavera, Leonor; Posadas-Romero, Carlos; Posadas-Sánchez, Rosalinda; López-Contreras, Blanca E.; Morán-Ramos, Sofía; Romero-Hidalgo, Sandra; Acuña-Alonzo, Víctor; Del-Río-Navarro, Blanca E.; Bortolini, Maria-Cátira; Gallo López-Aliaga, Carla Maria; Bedoya, Gabriel; Rothhammer, Francisco; González-Jose, Rolando; Ruiz-Linares, Andrés; Stephens, Christopher R.; Velazquez-Cruz, Rafael; Fernández Del Valle-Laisequilla, Cecilia; Reyes-García, Juan G.; Barranco Garduño, Lina M.; Carrasco-Portugal, Miriam Del C.; Flores-Murrieta, Francisco J.; Vargas-Alarcón, Gilberto; Aguilar-Salinas, Carlos A.; Villarreal-Molina, Teresa; Canizales-Quinteros, Samuel (Elsevier, 2018)
    BACKGROUND: Serum uric acid (SUA) is a heritable trait associated with cardiovascular risk factors and coronary artery disease (CAD). Genome wide association studies (GWAS) have identified several genes associated with ...
  • Campos, M.; Alonso, D.P.; Conn, J.E.; Vinetz, Joseph Michael; Emerson, K.J.; Ribolla, P.E.M. (BioMed Central, 2019)
    BACKGROUND: In the Amazon Basin, Nyssorhynchus (Anopheles) darlingi is the most aggressive and effective malaria vector. In endemic areas, behavioral aspects of anopheline vectors such as host preference, biting time and ...
  • Heinrich, E.C.; Wu, L.; Lawrence, E.S.; Cole, A.M.; Anza-Ramirez, C.; Villafuerte, Francisco C.; Simonson, T.S. (Wiley, 2019)
    EGLN1 encodes the hypoxia-inducible factor (HIF) pathway prolyl hydroxylase 2 (PHD2) that serves as an oxygen-sensitive regulator of HIF activity. The EGLN1 locus exhibits a signature of positive selection in Tibetan and ...
  • Fuentes, Macarena; Pulgar, Iván; Gallo López-Aliaga, Carla Maria; Bortolini, María-Cátira; Canizales-Quinteros, Samuel; Bedoya, Gabriel; González-José, Rolando; Ruiz-Linares, Andrés; Rothhammer, Francisco (Sociedad Médica de Santiago, 2014)
    Background: The geographical distribution of genes plays a key role in genetic epidemiology. The Chilean population has three major stem groups (Native American, European and African). Aim: To estimate the regional rate ...
  • 1000 Genomes Project; Auton, A.; Abecasis, G.R.; Altshuler, D.M.; Durbin, R.M.; Bentley, D.R.; Chakravarti, A.; Clark, A.G.; Donnelly, P.; Eichler, E.E.; Flicek, P.; Gabriel, S.B.; Gibbs, R.A.; Green, E.D.; Hurles, M.E.; Knoppers, B.M.; Korbel, J.O.; Lander, E.S.; Lee, C.; Lehrach, H.; Mardis, E.R.; Marth, G.T.; McVean, G.A.; Nickerson, D.A.; Schmidt, J.P.; Sherry, S.T.; Wang, J.; Wilson, R.K.; Boerwinkle, E.; Doddapaneni, H.; Han, Y.; Korchina, V.; Kovar, C.; Lee, S.; Muzny, D.; Reid, J.G.; Zhu, Y.; Chang, Y.; Feng, Q.; Fang, X.; Guo, X.; Jian, M.; Jiang, H.; Jin, X.; Lan, T.; Li, G.; Li, J.; Li, Y.; Liu, S.; Liu, X.; Lu, Y.; Ma, X.; Tang, M.; Wang, B.; Wang, G.; Wu, H.; Wu, R.; Xu, X.; Yin, Y.; Zhang, D.; Zhang, W.; Zhao, J.; Zhao, M.; Zheng, X.; Gupta, N.; Gharani, N.; Toji, L.H.; Gerry, N.P.; Resch, A.M.; Barker, J.; Clarke, L.; Gil, L.; Hunt, S.E.; Kelman, G.; Kulesha, E.; Leinonen, R.; McLaren, W.M.; Radhakrishnan, R.; Roa, A.; Smirnov, D.; Smith, R.E.; Streeter, I.; Thormann, A.; Toneva, I.; Vaughan, B.; Zheng-Bradley, X.; Grocock, R.; Humphray, S.; James, T.; Kingsbury, Z.; Sudbrak, R.; Albrecht, M.W.; Amstislavskiy, V.S.; Borodina, T.A.; Lienhard, M.; Mertes, F.; Sultan, M.; Timmermann, B.; Yaspo, M.-L.; Fulton, L.; Ananiev, V.; Belaia, Z.; Beloslyudtsev, D.; Bouk, N.; Chen, C.; Church, D.; Cohen, R.; Cook, C.; Garner, J.; Hefferon, T.; Kimelman, M.; Liu, C.; Lopez, J.; Meric, P.; O'Sullivan, C.; Ostapchuk, Y.; Phan, L.; Ponomarov, S.; Schneider, V.; Shekhtman, E.; Sirotkin, K.; Slotta, D.; Zhang, H.; Balasubramaniam, S.; Burton, J.; Danecek, P.; Keane, T.M.; Kolb-Kokocinski, A.; McCarthy, S.; Stalker, J.; Quail, M.; Davies, C.J.; Gollub, J.; Webster, T.; Wong, B.; Zhan, Y.; Campbell, C.L.; Kong, Y.; Marcketta, A.; Yu, F.; Antunes, L.; Bainbridge, M.; Sabo, A.; Huang, Z.; Coin, L.J.M.; Fang, L.; Li, Q.; Li, Z.; Lin, H.; Liu, B.; Luo, R.; Shao, H.; Xie, Y.; Ye, C.; Yu, C.; Zhang, F.; Zheng, H.; Zhu, H.; Alkan, C.; Dal, E.; Kahveci, F.; Garrison, E.P.; Kural, D.; Lee, W.-P.; Leong, W.F.; Stromberg, M.; Ward, A.N.; Wu, J.; Zhang, M.; Daly, M.J.; DePristo, M.A.; Handsaker, R.E.; Banks, E.; Bhatia, G.; Del Angel, G.; Genovese, G.; Li, H.; Kashin, S.; McCarroll, S.A.; Nemesh, J.C.; Poplin, R.E.; Yoon, S.C.; Lihm, J.; Makarov, V.; Gottipati, S.; Keinan, A.; Rodriguez-Flores, J.L.; Rausch, T.; Fritz, M.H.; Stütz, A.M.; Beal, K.; Datta, A.; Herrero, J.; Ritchie, G.R.S.; Zerbino, D.; Sabeti, P.C.; Shlyakhter, I.; Schaffner, S.F.; Vitti, J.; Cooper, D.N.; Ball, E.V.; Stenson, P.D.; Barnes, B.; Bauer, M.; Cheetham, R.K.; Cox, A.; Eberle, M.; Kahn, S.; Murray, L.; Peden, J.; Shaw, R.; Kenny, E.E.; Batzer, M.A.; Konkel, M.K.; Walker, J.A.; MacArthur, D.G.; Lek, M.; Herwig, R.; Ding, L.; Koboldt, D.C.; Larson, D.; Ye, K.; Gravel, S.; Swaroop, A.; Chew, E.; Lappalainen, T.; Erlich, Y.; Gymrek, M.; Willems, T.F.; Simpson, J.T.; Shriver, M.D.; Rosenfeld, J.A.; Bustamante, C.D.; Montgomery, S.B.; De La Vega, F.M.; Byrnes, J.K.; Carroll, A.W.; DeGorter, M.K.; Lacroute, P.; Maples, B.K.; Martin, A.R.; Moreno-Estrada, A.; Shringarpure, S.S.; Zakharia, F.; Halperin, E.; Baran, Y.; Cerveira, E.; Hwang, J.; Malhotra, A.; Plewczynski, D.; Radew, K.; Romanovitch, M.; Zhang, C.; Hyland, F.C.L.; Craig, D.W.; Christoforides, A.; Homer, N.; Izatt, T.; Kurdoglu, A.A.; Sinari, S.A.; Squire, K.; Xiao, C.; Sebat, J.; Antaki, D.; Gujral, M.; Noor, A.; Ye, K.; Burchard, E.G.; Hernandez, R.D.; Gignoux, C.R.; Haussler, D.; Katzman, S.J.; Kent, W.J.; Howie, B.; Ruiz-Linares, A.; Dermitzakis, E.T.; Devine, S.E.; Kang, H.M.; Kidd, J.M.; Blackwell, T.; Caron, S.; Chen, W.; Emery, S.; Fritsche, L.; Fuchsberger, C.; Jun, G.; Li, B.; Lyons, R.; Scheller, C.; Sidore, C.; Song, S.; Sliwerska, E.; Taliun, D.; Tan, A.; Welch, R.; Wing, M.K.; Zhan, X.; Awadalla, P.; Hodgkinson, A.; Li, Y.; Shi, X.; Quitadamo, A.; Lunter, G.; Marchini, J.L.; Myers, S.; Churchhouse, C.; Delaneau, O.; Gupta-Hinch, A.; Kretzschmar, W.; Iqbal, Z.; Mathieson, I.; Menelaou, A.; Rimmer, A.; Xifara, D.K.; Oleksyk, T.K.; Fu, Y.; Liu, X.; Xiong, M.; Jorde, L.; Witherspoon, D.; Xing, J.; Browning, B.L.; Browning, S.R.; Hormozdiari, F.; Sudmant, P.H.; Khurana, E.; Tyler-Smith, C.; Albers, C.A.; Ayub, Q.; Chen, Y.; Colonna, V.; Jostins, L.; Walter, K.; Xue, Y.; Gerstein, M.B.; Abyzov, A.; Balasubramanian, S.; Chen, J.; Clarke, D.; Fu, Y.; Harmanci, A.O.; Jin, M.; Lee, D.; Liu, J.; Mu, X.J.; Zhang, J.; Zhang, Y.; Hartl, C.; Shakir, K.; Degenhardt, J.; Meiers, S.; Raeder, B.; Casale, F.P.; Stegle, O.; Lameijer, E.-W.; Hall, I.; Bafna, V.; Michaelson, J.; Gardner, E.J.; Mills, R.E.; Dayama, G.; Chen, K.; Fan, X.; Chong, Z.; Chen, T.; Chaisson, M.J.; Huddleston, J.; Malig, M.; Nelson, B.J.; Parrish, N.F.; Blackburne, B.; Lindsay, S.J.; Ning, Z.; Zhang, Y.; Lam, H.; Sisu, C.; Challis, D.; Evani, U.S.; Lu, J.; Nagaswamy, U.; Yu, J.; Li, W.; Habegger, L.; Yu, H.; Cunningham, F.; Dunham, I.; Lage, K.; Jespersen, J.B.; Horn, H.; Kim, D.; Desalle, R.; Narechania, A.; Sayres, M.A.W.; Mendez, F.L.; Poznik, G.D.; Underhill, P.A.; Mittelman, D.; Banerjee, R.; Cerezo, M.; Fitzgerald, T.W.; Louzada, S.; Massaia, A.; Yang, F.; Kalra, D.; Hale, W.; Dan, X.; Barnes, K.C.; Beiswanger, C.; Cai, H.; Cao, H.; Henn, B.; Jones, D.; Kaye, J.S.; Kent, A.; Kerasidou, A.; Mathias, R.; Ossorio, P.N.; Parker, M.; Rotimi, C.N.; Royal, C.D.; Sandoval, K.; Su, Y.; Tian, Z.; Tishkoff, S.; Via, M.; Wang, Y.; Yang, H.; Yang, L.; Zhu, J.; Bodmer, W.; Bedoya, G.; Cai, Z.; Gao, Y.; Chu, J.; Peltonen, L.; Garcia-Montero, A.; Orfao, A.; Dutil, J.; Martinez-Cruzado, J.C.; Mathias, R.A.; Hennis, A.; Watson, H.; McKenzie, C.; Qadri, F.; LaRocque, R.; Deng, X.; Asogun, D.; Folarin, O.; Happi, C.; Omoniwa, O.; Stremlau, M.; Tariyal, R.; Jallow, M.; Joof, F.S.; Corrah, T.; Rockett, K.; Kwiatkowski, D.; Kooner, J.; Hien, T.T.; Dunstan, S.J.; ThuyHang, N.; Fonnie, R.; Garry, R.; Kanneh, L.; Moses, L.; Schieffelin, J.; Grant, D.S.; Gallo López-Aliaga, Carla Maria; Poletti, Giovanni; Saleheen, D.; Rasheed, A.; Brooks, L.D.; Felsenfeld, A.L.; McEwen, J.E.; Vaydylevich, Y.; Duncanson, A.; Dunn, M.; Schloss, J.A. (Springer Nature, 2015)
    The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations. Here we report ...
  • de Oliveira Mendes, Tiago Antonio; Reis Cunha, Joao Luís; de Almeida Lourdes, Rodrigo; Rodrigues Luiz, Gabriela Flávia; Lemos, Lucas Dhom; dos Santos, Ana Rita Rocha; da Câmara, Antonia Cláudia Jácome; da Cunha Galvão, Lúcia Maria; Bern, Caryn; Gilman, Robert Hugh; Fujiwara, Ricardo Tostes; Gazzinelli, Ricardo Tostes; Bartholomeu, Daniella Castanheira (Public Library of Science, 2013)
    The factors influencing variation in the clinical forms of Chagas disease have not been elucidated; however, it is likely that the genetics of both the host and the parasite are involved. Several studies have attempted to ...
  • Cerqueira, Caio Cesar Silva de; Hünemeier, Tábita; Gomez-Valdés, Jorge; Ramallo, Virgínia; Volasko-Krause, Carla Daiana; Barbosa, Ana Angélica Leal; Vargas-Pinilla, Pedro; Dornelles, Rodrigo Ciconet; Longo, Danaê; Rothhammer, Francisco; Bedoya, Gabriel; Canizales-Quinteros, Samuel; Acuña-Alonzo, Victor; Gallo López-Aliaga, Carla Maria; Poletti, Giovanni; González-José, Rolando; Salzano, Francisco Mauro; Callegari-Jacques, Sídia Maria; Schuler-Faccini, Lavínia; Ruiz-Linares, Andrés; Cátira Bortolini, Maria (Public Library of Science, 2014)
    The understanding of the complex genotype-phenotype architecture of human pigmentation has clear implications for the evolutionary history of humans, as well as for medical and forensic practices. Although dozens of genes ...
  • Diniz, Pedro Paulo V.P.; Morton, Bridget A.; Tngrian, Maryam; Kachani, Malika; Barrón, Eduardo A.; Gavidia, Cesar M.; Gilman, Robert Hugh; Angulo, Noelia P.; Brenner, Elliott C.; Lerner, Richard; Chomel, Bruno B. (Public Library of Science, 2013)
    Bartonella species are emerging infectious organisms transmitted by arthropods capable of causing long-lasting infection in mammalian hosts. Among over 30 species described from four continents to date, 15 are known to ...
  • Gladstone, Rebecca A.; Lo, Stephanie W.; Lees, John A.; Croucher, Nicholas J.; van Tonder, Andries J.; Corander, Jukka; Page, Andrew J.; Marttinen, Pekka; Bentley, Leon J.; Ochoa Woodell, Theresa Jean; Ho, Pak Leung; du Plessis, Mignon; Cornick, Jennifer E.; Kwambana-Adams, Brenda; Benisty, Rachel; Nzenze, Susan A.; Madhi, Shabir A.; Hawkins, Paulina A.; Everett, Dean B.; Antonio, Martin; Dagan, Ron; Klugman, Keith P.; von Gottberg, Anne; McGee, Lesley; Breiman, Robert F.; Bentley, Stephen D. (Elsevier, 2019)
    Background: Pneumococcal conjugate vaccines have reduced the incidence of invasive pneumococcal disease, caused by vaccine serotypes, but non-vaccine-serotypes remain a concern. We used whole genome sequencing to study ...

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