Publicación:

In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa

Resumen

Anredera diffusa is used as a wound-healing agent in traditional Peruvian medicine. Acid hydrolysis of the bioactive ethanolic extract, followed by in vivo activity-guided fractionation, yielded oleanolic acid, with a wound-healing activity equivalent to 42.9% (p < 0.01) above the control. The highest cicatrizant activity in mice was obtained by applying 40 μg of oleanolic acid per gram of body weight. © 2006 American Chemical Society and American Society of Pharmacognosy.