DSpace Repository
High anti-SARS-CoV-2 antibody seroconversion rates before the second wave in Manaus, Brazil, and the protective effect of social behaviour measures: results from the prospective DETECTCoV-19 cohort
- DSpace Home
- →
- Artículos
- →
- Editados por otras instituciones
- →
- Artículos en revistas indizadas
- →
- View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.
High anti-SARS-CoV-2 antibody seroconversion rates before the second wave in Manaus, Brazil, and the protective effect of social behaviour measures: results from the prospective DETECTCoV-19 cohort
Lalwani, P.; Araujo-Castillo, R.V.; Ganoza Gallardo, Christian Alejandro; Salgado, B.B.; Pereira Filho, I.V.; da Silva, D.S.S.; de Morais, T.B.D.N.; Jordão, M.F.; Ortiz, J.V.; Barbosa, A.R.C.; Sobrinho, W.B.S.; Cordeiro, I.B.; de Souza Neto, J.N.; de Assunção, E.N.; da Costa, C.F.; de Souza, P.E.; de Albuquerque, B.C.; Astofi-Filho, S.; Holanda, A.I.P.; Gomes, A.L.S.; França, A.P.S.D.; Monteiro, A.V.R.; Santos, A.D.P.; Teixeira, A.D.S.; Souza, A.V.S.D.; Pinheiro, B.; Santos, B.P.D.; Farias, B.P.; Paulino, B.N.; Silva, C.L.A.D.; Oliveira, C.I.F.B.D.; Martins, D.D.A.; Oliveira, E.A.D.; Carvalho, E.D.D.C.; Costa, E.F.D.; Simplicio, F.G.; Pereira, F.S.; Sinimbu, G.P.; Cardenes, G.D.O.; Silva, G.A.D.; Costa, I.S.F.D.; Correia, I.S.; Santos, I.G.C.D.; Guimarães, J.V.; Pinheiro, J.S.B.; Romana, J.C.; França, J.D.O.N.; Pinto, K.R.; Freitas, M.F.F.; Vasconcellos, M.C.D.; Moraes, M.C.; Damasceno, M.D.S.; Ruiz, M.A.; Lemos, M.M.C.D.; Picanço, N.S.; Maia, R.G.; Bezerra, R.C.; Souza, R.S.D.; Harjani, S.C.; Souza, V.B.D.; Melo, W.B.D.; Lalwani, J.D.B.; the DETECTCoV-19 Study Team
Date:
2021
Abstract:
Background: The city of Manaus, Brazil, has seen two collapses of the health system due to the COVID-19 pandemic. We report anti-SARS-CoV-2 nucleocapsid IgG antibody seroconversion rates and associated risk factors in Manaus residents before the second wave of the epidemic in Brazil. Methods: A convenience sample of adult (aged ≥18 years) residents of Manaus was recruited through online and university website advertising into the DETECTCoV-19 study cohort. The current analysis of seroconversion included a subgroup of DETECTCoV-19 participants who had at least two serum sample collections separated by at least 4 weeks between Aug 19 and Oct 2, 2020 (visit 1), and Oct 19 and Nov 27, 2020 (visit 2). Those who reported (or had no data on) having a COVID-19 diagnosis before visit 1, and who were positive for anti-SARS-CoV-2 nucleocapsid IgG antibodies at visit 1 were excluded. Using an in-house ELISA, the reactivity index (RI; calculated as the optical density ratio of the sample to the negative control) for serum anti-SARS-CoV-2 nucleocapsid IgG antibodies was measured at both visits. We calculated the incidence of seroconversion (defined as RI values ≤1·5 at visit 1 and ≥1·5 at visit 2, and a ratio >2 between the visit 2 and visit 1 RI values) during the study period, as well as incidence rate ratios (IRRs) through cluster-corrected and adjusted Poisson regression models to analyse associations between seroconversion and variables related to sociodemographic characteristics, health access, comorbidities, COVID-19 exposure, protective behaviours, and symptoms. Findings: 2496 DETECTCoV-19 cohort participants returned for a follow-up visit between Oct 19 and Nov 27, 2020, of whom 204 reported having COVID-19 before the first visit and 24 had no data regarding previous disease status. 559 participants were seropositive for anti-SARS-CoV-2 nucleocapsid IgG antibodies at baseline. Of the remaining 1709 participants who were seronegative at baseline, 71 did not meet the criteria for seroconversion and were excluded from the analyses. Among the remaining 1638 participants who were seronegative at baseline, 214 showed seroconversion at visit 2. The seroconversion incidence was 13·06% (95% CI 11·52–14·79) overall and 6·78% (5·61–8·10) for symptomatic seroconversion, over a median follow-up period of 57 days (IQR 54–61). 48·1% of seroconversion events were estimated to be asymptomatic. The sample had higher proportions of affluent and higher-educated people than those reported for the Manaus city population. In the fully adjusted and corrected model, risk factors for seroconversion before visit 2 were having a COVID-19 case in the household (IRR 1·49 [95% CI 1·21–1·83]), not wearing a mask during contact with a person with COVID-19 (1·25 [1·09–1·45]), relaxation of physical distancing (1·31 [1·05–1·64]), and having flu-like symptoms (1·79 [1·23–2·59]) or a COVID-19 diagnosis (3·57 [2·27–5·63]) between the first and second visits, whereas working remotely was associated with lower incidence (0·74 [0·56–0·97]). Interpretation: An intense infection transmission period preceded the second wave of COVID-19 in Manaus. Several modifiable behaviours increased the risk of seroconversion, including non-compliance with non-pharmaceutical interventions measures such as not wearing a mask during contact, relaxation of protective measures, and non-remote working. Increased testing in high-transmission areas is needed to provide timely information about ongoing transmission and aid appropriate implementation of transmission mitigation measures
Files in this item
| Files | Size | Format | View |
|---|---|---|---|
|
There are no files associated with this item. |
|||
This item appears in the following Collection(s)
-
Artículos en revistas indizadas [4988]
Recuperados de bases de datos bibliográficas
Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess
Related items
Showing items related by title, author, creator and subject.
-
Guimarães Alves, A.C.; Sukow, N.M.; Adelman Cipolla, G.; Mendes, M.; Leal, T.P.; Petzl-Erler, M.L.; Lehtonen Rodrigues Souza, R.; Rainha de Souza, I.; Sanchez, C.; Santolalla Robles, Meddly Leslye; Loesch, D.; Dean, M.; Machado, M.; Moon, J.-Y.; Kaplan, R.; North, K.E.; Weiss, S.; Barreto, M.L.; Lima-Costa, M.F.; Guio, H.; Cáceres, O.; Padilla, C.; Tarazona-Santos, E.; Mata, I.F.; Dieguez, E.; Raggio, V.; Lescano, Andrés; Tumas, V.; Borges, V.; Ferraz, H.B.; Rieder, C.R.; Schumacher-Schuh, A.; Santos-Lobato, B.L.; Chana-Cuevas, P.; Fernandez, W.; Arboleda, G.; Arboleda, H.; Arboleda-Bustos, C.E.; O’Connor, T.D.; Beltrame, M.H.; Borda, V. (Frontiers Media, 2021)In adulthood, the ability to digest lactose, the main sugar present in milk of mammals, is a phenotype (lactase persistence) observed in historically herder populations, mainly Northern Europeans, Eastern Africans, and ...
-
Gouveia, Mateus H.; Borda, Victor; Leal, Thiago P.; Moreira, Rennan G.; Bergen, Andrew W.; Kehdy, Fernanda S. G.; Alvim, Isabela; Aquino, Marla M.; Araujo, Gilderlanio S.; Araujo, Nathalia M.; Furlan, Vinicius; Liboredo, Raquel; Machado, Moara; Magalhaes, Wagner C. S.; Michelin, Lucas A.; Rodrigues, Maíra R.; Rodrigues-Soares, Fernanda; Sant Anna, Hanaisa P.; Santolalla Robles, Meddly Leslye; Scliar, Marília O.; Soares-Souza, Giordano; Zamudio, Roxana; Zolini, Camila; Bortolini, Maria Catira; Dean, Michael; Gilman, Robert Hugh; Guio, Heinner; Rocha, Jorge; Pereira, Alexandre C.; Barreto, Mauricio L.; Horta, Bernardo L.; Lima-Costa, Maria F.; Mbulaiteye, Sam M.; Chanock, Stephen J.; Tishkoff, Sarah A.; Yeager, Meredith; Tarazona-Santos, Eduardo (Oxford University Press, 2020)The Transatlantic Slave Trade transported more than 9 million Africans to the Americas between the early 16th and the mid-19th centuries. We performed a genome-wide analysis using 6,267 individuals from 25 populations to ...
-
Lazarus, J. V.; Romero, D.; Kopka, C. J.; Karim, S. A.; Abu-Raddad, L. J.; Almeida, G.; Baptista-Leite, R.; Barocas, J. A.; Barreto, M. L.; Bar-Yam, Y.; Bassat, Q.; Batista, C.; Bazilian, M.; Chiou, S.-T.; del Rio, C.; Dore, G. J.; Gao, G. F.; Gostin, L. O.; Hellard, M.; Jimenez, J. L.; Kang, G.; Lee, N.; Matičič, M.; McKee, M.; Nsanzimana, S.; Oliu-Barton, M.; Pradelski, B.; Pyzik, O.; Rabin, K.; Raina, S.; Rashid, S.F.; Rathe, M.; Saenz, R.; Singh, S.; Trock-Hempler, M.; Villapol, S.; Yap, P.; Binagwaho, A.; Kamarulzaman, A.; El-Mohandes, A.; Barreto, M.; del Rio, C.; Abdulla, S.; Addleman, S.; Aghayeva, G.; Agius, R.; Ahmed, M.; Ramy, M. A.; Aide, P.; Aleman, S.; Alfred, J.-P.; Ali, S.; Aliaga, J.; Aloudat, T.; Alqahtani, S. A.; Al-Salman, J.; Amuasi, J. H.; Agrawal, A.; Anwar, W.; Araujo-Jorge, T.; Artaza, O.; Asadi, L.; Awuku, Y.; Baker, M.; Barberia, L.; Bascolo, E.; Belcher, P.; Bell, L.; Benzaken, A.; Bergholtz, E.; Bhadelia, N.; Bhan, A.; Bilodeau, S.; Bitrán, R.; Bluyssen, P.; Bosman, A.; Bozza, F. A.; Brinkmann, M. M.; Brown, A.; Mellado, B.; Bukusi, E.; Bullen, C.; Buonanno, G.; Burgess, R.; Butler, M.; Byakika-Kibwika, P.; Cabieses, B.; Carlsson, G.; Cascini, F.; Chabala, C.; Chakroun, M.; Cheng, K. K.; Chetty, A.; Chumachenko, D.; Consalves, G.; Conway Morris, A.; Cordie, A.; Corrah, T.; Crabtree-Ramírez, B.; Dashdorj, N.; Davidovitch, N.; de Souza, L. E.; Dhariwal, A. C.; Druică, E.; Ergonul, O.; Erondu, N. A.; Essar, M. Y.; Ewing, A.; Fanjul, G.; Feierstein, D.; Feigl-Ding, E.; Figueroa, R.; Figueroa, J.P.; Fisher, D.; Flores, W.; Forero-Peña, D. A.; Frumkin, H.; Gamkrelidze, A.; Gandhi, M.; Garcia Funegra, Patricia Jannet; Garcia-Basteiro, A. L.; García-Sastre, A.; Garg, S.; Gbeasor-Komlanvi, F. A.; Gershenson, C.; Gilada, I.; Giovanella, L.; González, M.; Green, M. S.; Greenhalgh, T.; Griffin, P.; Griffin, S.; Grinsztejn, B.; Anand, T.; Guerra, G.; Guinto, R.; Gujski, M.; Guner, R.; Hamdy, A.; Hâncean, M.-G.; Haniffa, A.; Hartigan-Go, K. Y.; Hassan, H. K.; Hay, S. I.; Heino, M. T. J.; Hel, Z.; Hotez, P.; Hu, J.; Hukić, M.; IJsselmuiden, C.; Iroko, D.; Iskarous, M.; Izugbara, C.; Jacobs, C.; Jadad, A. R.; Jehan, F.; Jordan, A.; Jroundi, I.; Kain, K.; Kamberi, F.; Karamov, E.; Karan, A.; Katz, R.; Katzourakis, A.; Kazembe, A.; Khamis, F.; Khamzayev, K.; Khanyola, J.; Khunti, K.; Kiguli-Malwadde, E.; Kim, W. J.; Kirenga, B. J.; Klimovský, D.; Kmush, B. L.; Knaul, F.; Kogevinas, M.; Kristensen, F.; Kumar, D.; Kumar, R.; Kvalsvig, A.; Lacerda, M. V.; Lal, A.; Lawton, T.; Lemery, J.; Leonardi, A. J.; Li, Y.; Löttvall, J.; Lounis, M.; Maceira, D.; MacIntyre, C. R.; Madani, A.; Magiorkinis, G.; Malekzadeh, R.; Choisy, M.; Marcelin, J. R.; Marks, G. B.; Marr, L.; Marrazzo, J.; Martina, A.; Martín-Moreno, J. M.; Mateos, C.; Mayxay, M.; Mazarati, J. B.; Mboup, S.; McDonald, J.; McMillan, F.; Mechili, E.; Medici, A.; Davis, S. L. M.; Meier, P.; Memish, Z. A.; Menon, J.; Menon, P.; Mesiano-Crookston, J.; Michie, S.; Mikolasevic, I.; Milicevic, O.; Mishra, A. K.; Mohamed, R.; Mokdad, A. H.; Monroy-Valle, M.; Morawska, L.; Moschos, S. A.; Motawea, K.; Mousavi, S. H.; Mumtaz, G.; Munene, P. K.; Muñoz Almagro, C.; Muriuki, J.; Muyingo, S.; Naniche, D.; Naylor, C. D.; Ndembi, N.; Nemec, J.; Nesteruk, I.; Ngaruiya, C.; Nguyen, H.; Nikolova, D.; Nitzan, D.; Norheim, O.; Noushad, M.; Ntoumi, F.; Nyborg, G. A.; Ochodo, E.; Odabasi, Z.; Okwen, M. P.; Olivia, K.; Ong, D. S. Y.; Opara, I.; Orozco, M.; Oshitani, H.; Pagel, C.; Pai, M.; Pálsdóttir, B.; Papatheodoridis, G.; Paraskevis, D.; Leigh, J. P.; Pécoul, B.; Peichl, A.; Perez-Then, E.; Duc, P. P.; Philippe, C.; Pineda Rojas, A.; Pladsen, C.; Pozniak, A.; Quiroga, R.; Qureshi, H.; Rampal, S.; Ranney, M.; Rathe, L.; Ratzan, S.; Raventos, H.; Rees, H.; Reis, R.; Ricciardi, W.; Rizk, N.; Robalo, M.; Robertson, E.; Robinson, L.; Rokx, C.; Ros, T.; Røttingen, J.-A.; Rubin, M.; Ruxrungtam, K.; Sadirova, S.; Saha, S.; Salgado, N.; Sanchez, L.; Sangaramoorthy, T.; Santamaria-Ulloa, C.; Santos, R.; Sawaf, B.; Schneider, M. F.; Schooley, R. T.; Sener, A.; Sepulveda, J.; Shah, J.; Shibani, M.; Shoib, S.; Sikazwe, I.; Šimaitis, A.; Gill, A. S.; Skhvitaridze, N.; Sokolović, M.; Solomon, R.; Solórzano, X.; Springer, S. A.; Šrol, J.; Staines, A.; Stelfox, H. T.; Strathdee, S.; Sulaiman, L. H.; Sutton, B.; Svanæs, D.; Swed, S.; Sypsa, V.; Sørensen, K.; Tajudeen, R.; Tan, A.; Tang, J.; Tanner, M.; Sethi, T.; Temmerman, M.; Than, K. K.; Tinto, H.; Tomètissi, S. P.; Torres, I.; Tshering, K. P.; Tsiodras, S.; Tsofa, B.; Vahlne, A.; Vargas, J. R.; Bernal, I. D. V.; Ventura, D.; Vilasanjuan, R.; Vipond, J.; Wamala-Andersson, S.; Wargocki, P.; West, R.; Weyand, A.; White, T. M.; Wolff, G.; Yao, M.; Yates, C.A.; Yeboah, G.; Yee-Sin, L.; Yi, S.; Teo, Y.-Y.; Yong, P.; Zamora-Mesía, V.; Øvrehus, A.; The COVID-19 Consensus Statement Panel (Springer, 2022)Despite notable scientific and medical advances, broader political, socioeconomic and behavioural factors continue to undercut the response to the COVID-19 pandemic1,2. Here we convened, as part of this Delphi study, a ...
Search DSpace
Browse
-
All of DSpace
-
This Collection
