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Additional evidence to support the phasing-out of treatment category II regimen for pulmonary tuberculosis in Peru

Additional evidence to support the phasing-out of treatment category II regimen for pulmonary tuberculosis in Peru

Ponce, M.; Ugarte Gil, Cesar Augusto; Zamudio Fuertes, Carlos Eduardo; Krapp, F.; Gotuzzo Herencia, José Eduardo; Seas Ramos, Carlos Rafael
URI: https://hdl.handle.net/20.500.12866/10892
Date: 2012

Abstract:

The effectiveness of the World Health Organization's (WHO) treatment category II regimen for tuberculosis in 124 patients was compared to that of 1147 patients receiving treatment category I in Lima, Peru following WHO's guidelines. Drug susceptibility test was available for 85% of patients. Prevalence of multi drug resistance and streptomycin resistance were 5.1% and 20.7%, respectively. Overall cure rate for regimen II was lower than that of regimen I: 67.8% (95% CI: 58.9-75.6.) vs 77.8% (95% CI: 75.3-80.2), p = 0.014. Multi-drug resistance exerted a profound effect on cure rates in both regimens. Our results support the phasing-out of treatment category II regimen in Peru.

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