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Relationship between interpregnancy interval and birth defects in Washington State

Relationship between interpregnancy interval and birth defects in Washington State

Kwon, S.; Lazo-Escalante, M.; Villaran, M.V.; Li, C.I.
URI: https://hdl.handle.net/20.500.12866/10916
Date: 2012

Abstract:

Objective: Interpregnancy interval (IPI) influences numerous adverse perinatal outcomes. IPI's impact on birth defects is unclear. Study Design:We conducted a population-based case-control study, using 1998 to 2008 administrative data from Washington State. A total of 10 772 cases, women whose second of two births resulted in an infant with a birth defect, were compared with 32 310 controls, women whose second of two births did not result in an infant with a birth defect. Result: Compared with mothers with an IPI between 18 to 23 months, those with an IPI <6 months or ≥60 months had elevated risks of delivering an infant with a birth defect (odds ratio=1.15, 95% confidence interval: 1.03 to 1.28, and odds ratio=1.15, 95% confidence interval: 1.04 to 1.26, respectively). Conclusion: We observed a J-shaped relationship between IPI and risk of having an infant with a birth defect. As this is one of the first studies to evaluate this association, confirmatory studies are needed.

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