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Dihydrochalcones and benzoic acid derivatives from piper dennisii

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dc.contributor.author Cabanillas Amado, Billy Joel
dc.contributor.author Le Lamer, A.-C.
dc.contributor.author Castillo Pareja, Denis Helan
dc.contributor.author Arévalo Zelada, Jorge Luis
dc.contributor.author Estevez, Y.
dc.contributor.author Rojas, R.
dc.contributor.author Valadeau, C.
dc.contributor.author Bourdy, G.
dc.contributor.author Sauvain, Michel Henri Auguste
dc.contributor.author Fabre, N.
dc.date.accessioned 2022-01-18T19:26:50Z
dc.date.available 2022-01-18T19:26:50Z
dc.date.issued 2012
dc.identifier.uri https://hdl.handle.net/20.500.12866/10922
dc.description.abstract Two new dihydrochalcones, as well as eight known compounds, piperaduncin C, 2,6-dihydroxy-4-methoxydihydrochalcone, 4,2,6-trihydroxy-4-methoxydihydrochalcone, 4-hydroxy-3,5-bis(3-methyl-2- butenyl)-benzoic acid, 3,5-bis(3-methyl-2-butenyl)-4-methoxybenzoic acid, 4-hydroxy-3-(3-methyl-2-butenoyl)-5-(3-methyl-2-butenyl)-benzoic acid, 2,2-dimethyl-8-(3-methyl-2-butenyl)-2H-1-chromene-6-carboxylic acid, and 3-(3,7-dimethyl-2,6-octadienyl)-4-methoxybenzoic acid were isolated from the leaves of Piper dennisii Trelease (Piperaceae), using a bioassay-guided fractionation to determine their antileishmanial potential. Among them, compound 10 exhibited the best antileishmanial activity (IC= 20.8 M) against axenic amastigote forms of Leishmania amazonensis, with low cytotoxicity on murine macrophages. In the intracellular macrophage-infected model, compound 10 proved to be more active (IC= 4.2 M). The chemical structures of compounds 1-10 were established based on the analysis of the spectroscopic data. en_US
dc.language.iso eng
dc.publisher Georg Thieme Verlag
dc.relation.ispartofseries Planta Medica
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Controlled Study en_US
dc.subject Animal Cell en_US
dc.subject Amastigote en_US
dc.subject Disease Model en_US
dc.subject Macrophage en_US
dc.subject Leishmania en_US
dc.subject Plant Extract en_US
dc.subject Amphotericin B en_US
dc.subject Drug Isolation en_US
dc.subject Molecular Structure en_US
dc.subject Plant Leaf en_US
dc.subject Cytotoxicity en_US
dc.subject Drug Structure en_US
dc.subject Murinae en_US
dc.subject Antiprotozoal Agents en_US
dc.subject IC 50 en_US
dc.subject Leishmania Amazonensis en_US
dc.subject Antileishmanial Agent en_US
dc.subject Drug Activity en_US
dc.subject Chalcone Derivative en_US
dc.subject Chalcones en_US
dc.subject Inhibitory Concentration 50 en_US
dc.subject Macrophages Peritoneal en_US
dc.subject Bioassay en_US
dc.subject Fractionation en_US
dc.subject Spectroscopy en_US
dc.subject Piperaceae en_US
dc.subject Piper en_US
dc.subject Chemical Structure en_US
dc.subject 22 Dimethyl 8 (3 Methyl 2 Butenyl) 2h 1 Chromene 6 Carboxylic Acid en_US
dc.subject 2'6' Dihydroxy 4' Methoxydihydrochalcone en_US
dc.subject 3 (3'7' Dimethyl 2'6' Octadienyl) 4 Methoxybenzoic Acid en_US
dc.subject 35 Bis(3 Methyl 2 Butenyl) 4 Methoxybenzoic Acid en_US
dc.subject 4 Hydroxy 3 (3 Methyl 2 Butenoyl) 5 (3 Methyl 2 Butenyl)Benzoic Acid en_US
dc.subject 4 Hydroxy 35 Bis(3 Methyl 2 Butenyl)Benzoic Acid en_US
dc.subject 42'6' Trihydroxy 4' Methoxydihydrochalcone en_US
dc.subject Antileishmanial Activities en_US
dc.subject Benzoic Acid Derivative en_US
dc.subject Benzoic Acids en_US
dc.subject Dihydrochalcones en_US
dc.subject Drug Evaluation Preclinical en_US
dc.subject Piper (Plant) en_US
dc.subject Piper Dennisii|Piperaduncin C en_US
dc.title Dihydrochalcones and benzoic acid derivatives from piper dennisii en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1055/s-0031-1298459
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.00
dc.relation.issn 1439-0221


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