DSpace Repository
Time to HAART initiation after diagnosis and treatment of opportunistic infections in patients with AIDS in Latin America
- DSpace Home
- →
- Artículos
- →
- Editados por otras instituciones
- →
- Artículos en revistas indizadas
- →
- View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.
Time to HAART initiation after diagnosis and treatment of opportunistic infections in patients with AIDS in Latin America
Crabtree-Ramírez, B.; Caro-Vega, Y.; Shepherd, B.E.; Grinsztejn, B.; Wolff, M.; Cortes, C.P.; Padgett, D.; Carriquiry, G.; Fink, V.; Jayathilake, K.; Person, A.K.; McGowan, C.; Sierra-Madero, J.; CCASAnet
Date:
2016
Abstract:
Background: Since 2009, earlier initiation of highly active antiretroviral therapy (HAART) after an opportunistic infection (OI) has been recommended based on lower risks of death and AIDS-related progression found in clinical trials. Delay in HAART initiation after OIs may be an important barrier for successful outcomes in patients with advanced disease. Timing of HAART initiation after an OI in "real life" settings in Latin America has not been evaluated. Methods: Patients in the Caribbean, Central and South America network for HIV Epidemiology (CCA-SAnet) ≥18 years of age at enrolment, from 2001-2012 who had an OI before HAART initiation were included. Patients were divided in an early HAART (EH) group (those initiating within 4 weeks of an OI) and a delayed HAART (DH) group (those initiating more than 4 weeks after an OI). All patients with an AIDS-defining OI were included. In patients with more than one OI the first event reported was considered. Calendar trends in the proportion of patients in the EH group (before and after 2009) were estimated by site and for the whole cohort. Factors associated with EH were estimated using multivariable logistic regression models. Results: A total of 1457 patients had an OI before HAART initiation and were included in the analysis: 213 from Argentina, 686 from Brazil, 283 from Chile, 119 from Honduras and 156 from Mexico. Most prevalent OI were Tuberculosis (31%), followed by Pneumocystis pneumonia (24%), Invasive Candidiasis (16%) and Toxoplasmosis (9%). Median time from OI to HAART initiation decreased significantly from 5.7 (interquartile range [IQR] 2.8-12.1) weeks before 2009 to 4.3 (IQR 2.0-7.1) after 2009 (p<0.01). Factors associated with starting HAART within 4 weeks of OI diagnosis were lower CD4 count at enrolment (p-<0.001), having a non-tuberculosis OI (p<0.001), study site (p<0.001), and more recent years of OI diagnosis (p<0.001). Discussion: The time from diagnosis of an OI to HAART initiation has decreased in Latin America coinciding with the publication of evidence of its benefit. We found important heterogeneity between sites which may reflect differences in clinical practices, local guidelines, and access to HAART. The impact of the timing of HAART initiation after OI on patient survival in this "real life" context needs further evaluation.
Files in this item
| Files | Size | Format | View |
|---|---|---|---|
|
There are no files associated with this item. |
|||
This item appears in the following Collection(s)
-
Artículos en revistas indizadas [4988]
Recuperados de bases de datos bibliográficas
Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess
Related items
Showing items related by title, author, creator and subject.
-
Cesar, C.; Koethe, J.R.; Giganti, M.J.; Rebeiro, P.; Althoff, K.N.; Napravnik, S.; Mayor, A.; Grinsztejn, B.; Wolff, M.; Padgett, D.; Sierra Madero, J.; Gotuzzo Herencia, José Eduardo; Sterling, T.R.; Willig, J.; Levison, J.; Kitahata, M.; Rodriguez-Barradas, M.C.; Moore, R.D.; McGowan, C.; Shepherd, B.E.; Cahn, P. (Wiley, 2016)Introduction: Latinos living with HIV in the Americas share a common ethnic and cultural heritage. In North America, Latinos have a relatively high rate of new HIV infections but lower rates of engagement at all stages of ...
-
Wolff, M.; Shepherd, B.E.; Cortés, C.; Rebeiro, P.; Cesar, C.; Wagner Cardoso, S.; Pape, J.W.; Padgett, D.; Sierra-Madero, J.; Echevarria Zarate, Juan Ignacio; McGowan, C.C.; CCASAnet (Wolters Kluwer Health, 2016)Background: HIV-infected persons in resource-limited settings may experience high rates of antiretroviral therapy (ART) change, particularly because of toxicity or other nonfailure reasons. Few reports address patient ...
-
Charles, M.K.; Lindegren, M.L.; Wester, C.W.; Blevins, M.; Sterling, T.R.; Dung, N.T.; Dusingize, J.C.; Avit-Edi, D.; Durier, N.; Castelnuovo, B.; Nakigozi, G.; Cortes, C.P.; Ballif, M.; Fenner, L.; Ajayi, S.; Anastos, K.; Bashi, J.; Bishai, W.; Boulle, A.; Braitstein, P.; Carriquiry, G.; Carter, J.E.; Cegielski, P.; Chimbetete, C.; Davies, M.-A.; Diero, L.; Duda, S.; Egger, M.; Eboua, T.F.; Gasser, A.; Geng, E.; Gnokori, J.C.; Hardwicke, L.; Hoffmann, C.; Huebner, R.; Kancheya, N.; Kiertiburanakul, S.; Kim, P.; Lameck, D.; Leroy, V.; Lewden, C.; Mandalakas, A.; Maskew, M.; McKaig, R.; Mofenson, L.; Mpoudi-Etame, M.; Okwara, B.; Phiri, S.; Prasitsuebsai, W.; Petit, A.; Prozesky, H.; Reid, S.E.; Renner, L.; Reubenson, G.; Sohn, A.; Vo, Q.; Walker, D.; Wehbe, F.; Wejse, C.; Williams, C.; Wood, R.; Wools-Kaloustian, K.; Yao, Z.; Yunihastuti, E.; Zhang, F.J.; Zhao, H.X.; Han, N.; Merati, T.P.; Wirawan, D.N.; Yuliana, F.; Ditangco, R.; Uy, E.; Bantique, R.; Phanuphak, P.; Ruxrungtham, K.; Avihingsanon, A.; Khongphattanayothin, M.; Sungkanuparph, S.; Sanmeema, N.; Chaiwarith, R.; Sirisanthana, T.; Kotarathititum, W.; Pham, T.T.; Cuong, D.D.; Ha, H.L.; Nguyen, V.K.; Bui, V.H.; Nguyen, T.D.; Sohn, A.H.; Petersen, B.; Cooper, D.A.; Law, M.G.; Jiamsakul, A.; Boettiger, D.C.; Wati, D.K.; Atmikasari, L.P.P.; Malino, I.Y.; Nallusamy, R.; Chan, K.C.; Lumbiganon, P.; Kosalaraksa, P.; Tharnprisan, P.; Udomphanit, T.; Phongsamart, W.; Wittawatmongkol, O.; Dung, K.T.K.; Lam, N.V.; An, P.N.; Loan, N.T.; Truong, H.K.; Du, T.Q.; Chau, N.H.; Do, C.V.; Ha, M.T.; Nipathakosol, P.; Kariminia, A.; Mutimura, E.; Gitembagara, A.; Tatwangire, J.; Izabelle, I.; Niyongabo, T.; Twizere, C.; Baramperanye, E.; Edmonds, A.; Yotebieng, M.; Azinyue, I.; Ayangma, L.; Dickinson, D.; Eley, B.; Fritz, C.; Garone, D.; Giddy, J.; MacPhail, P.; Moultrie, H.; Ndirangu, J.; Pestilli, S.; Rabie, H.; Stringer, J.; Technau, K.; Graber, C.; Kaeser, F.; Keiser, O.; Cornell, M.; Maxwell, N.; Zannou, D.M.; Ahouada, C.; Akakpo, J.; Ahomadegbé, C.; Gougounon-Houéto, A.; Azon-Kouanou, A.; Houngbé, F.; Sehonou, J.; Koumakpaï, S.; Alihonou, F.; D'Almeida, M.; Hodonou, I.; Hounhoui, G.; Sagbo, G.; Tossa-Bagnan, L.; Adjide, H.; Drabo, J.; Bognounou, R.; Dienderé, A.; Traore, E.; Zoungrana, L.; Zerbo, B.; Sawadogo, A.B.; Zoungrana, J.; Héma, A.; Soré, I.; Bado, G.; Tapsoba, A.; Yé, D.; Kouéta, F.; Ouedraogo, S.; Ouédraogo, R.; Hiembo, W.; Gansonré, M.; Messou, E.; Gnokoro, J.C.; Koné, M.; Kouakou, G.M.; Bosse, C.A.; Brou, K.; Assi, A.I.; Chenal, H.; Hawerlander, D.; Soppi, F.; Minga, A.; Abo, Y.; Yoboue, J.-M.; Eholié, S.P.; Amego, M.D.N.; Andavi, V.; Diallo, Z.; Ello, F.; Tanon, A.K.; Koule, S.O.; Anzan, K.C.; Guehi, C.; Aka, E.A.; Issouf, K.L.; Kouakou, J.-C.; N'Gbeche, M.-S.; Pety, T.; Kouakou, K.; Moh, M.; Yao, V.A.; Folquet, M.A.; Dainguy, M.-E.; Kouakou, C.; Méa-Assande, V.T.; Oka-Berete, G.; Zobo, N.; Acquah, P.; Kokora, M.-B.; Timité-Konan, M.; Ahoussou, L.D.; Assouan, J.K.; Sami, M.F.; Kouadio, C.; Goka, B.; Welbeck, J.; Sackey, A.; Owiafe, S.N.; Da Silva, Z.J.; Paulo, J.; Rodrigues, A.; Da Silva, D.; Medina, C.; Oliviera-Souto, I.; Østergaard, L.; Laursen, A.; Sodemann, M.; Aaby, P.; Fomsgaard, A.; Erikstrup, C.; Eugen-Olsen, J.; Maïga, M.Y.; Diakité, F.F.; Kalle, A.; Katile, D.; Traore, H.A.; Minta, D.; Cissé, T.; Dembelé, M.; Doumbia, M.; Fomba, M.; Kaya, A.S.; Traoré, A.M.; Traoré, H.; Toure, A.A.; Dicko, F.; Sylla, M.; Berthé, A.; Traoré, H.C.; Koïta, A.; Koné, N.; N'Diaye, C.; Coulibaly, S.T.; Traoré, M.; Traoré, N.; Charurat, M.; Alim, G.; Dapiap, S.; Otu; Igbinoba, F.; Benson, O.; Adebamowo, C.; James, J.; Obaseki; Osakede, P.; Olasode, J.; Seydi, M.; Sow, P.S.; Diop, B.; Manga, N.M.; Tine, J.M.; Bassabi, C.C.; Sy, H.S.; Ba, A.; Diagne, A.; Dior, H.; Faye, M.; Gueye, R.D.; Mbaye, A.D.; Patassi, A.; Kotosso, A.; Kariyare, B.G.; Gbadamassi, G.; Komi, A.; Mensah-Zukong, K.E.; Pakpame, P.; Lawson-Evi, A.K.; Atakouma, Y.; Takassi, E.; Djeha, A.; Ephoévigah, A.; Djibril, S.E.-H.; Dabis, F.; Bissagnene, E.; Arrivé, E.; Coffie, P.; Ekouevi, D.; Jaquet, A.; Sasco, A.J.; Amani, D.; Azani, J.-C.; Balestre, E.; Bessekon, S.; Bohossou, F.; Gilbert, C.; Karcher, S.; Gonsan, J.M.; Le Carrou, J.; Lenaud, S.; Nchot, C.; Malateste, K.; Yao, A.R.; Siloué, B.; Clouet, G.; Dosso, M.; Doring, A.; Kouakou, A.; Rabourdin, E.; Rivenc, J.; Anglaret, X.; Ba, B.; Essanin, J.B.; Ciaranello, A.; Datté, S.; Desmonde, S.; Diby, J.-S.E.; Gottlieb, G.S.; Horo, A.G.; Kangah, S.N.; Malvy, D.; Meless, D.; Mounkaila-Harouna, A.; Ndondoki, C.; Shiboski, C.; Tchounga, B.; Thiébaut, R.; Wandeler, G.; McGowan, C.; Cahn, P.; Gotuzzo Herencia, José Eduardo; Reyes, M.W.; Grinsztejn, B.; Pape, J.W.; Padgett, D.; Madero, J.S. (Public Library of Science, 2016)Setting: World Health Organization advocates for integration of HIV-tuberculosis (TB) services and recommends intensive case finding (ICF), isoniazid preventive therapy (IPT), and infection control ("Three I's") for TB ...
Search DSpace
Browse
-
All of DSpace
-
This Collection
